Soluble urokinase receptor is a biomarker of cardiovascular disease in chronic kidney disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01

AUTHORS

Björn Meijers, Ruben Poesen, Kathleen Claes, Ruth Dietrich, Bert Bammens, Ben Sprangers, Maarten Naesens, Markus Storr, Dirk Kuypers, Pieter Evenepoel

ABSTRACT

Soluble urokinase-type plasminogen activator receptor (suPAR) accumulates in patients with chronic kidney disease (CKD). In various non-CKD populations, suPAR has been proposed as a prognostic marker for mortality and cardiovascular disease. However, it is not known whether suPAR holds prognostic information in patients with mild-to-moderate CKD. In a prospective observational study of 476 patients with mild-to-moderate kidney disease, we examined multivariate associations between suPAR, overall mortality, and cardiovascular events. After a mean follow-up of 57 months, 52 patients died and 76 patients had at least one fatal or nonfatal cardiovascular event. Higher suPAR was directly and significantly associated with both overall mortality (univariate hazard ratio 5.35) and cardiovascular events (univariate hazard ratio 5.06). In multivariate analysis, suPAR remained significantly associated with cardiovascular events (full model, hazard ratio 3.05). Thus, in patients with mild-to-moderate CKD, suPAR concentrations show a clear, direct, and graded association with a higher risk for new-onset cardiovascular disease. More... »

PAGES

210-216

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2014.197

DOI

http://dx.doi.org/10.1038/ki.2014.197

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039223949

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24897037


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