Malignancy-related mortality following kidney transplantation is common View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-06

AUTHORS

Daniela Farrugia, Sophia Mahboob, James Cheshire, Irena Begaj, Sajan Khosla, Daniel Ray, Adnan Sharif

ABSTRACT

There is a paucity of studies describing malignancy-related mortality after kidney transplantation. To help quantify this, we extracted data for all kidney-alone transplant procedures performed in England between April 2001 and March 2012. Data linkage analysis was performed between Hospital Episode Statistics and the Office for National Statistics to identify all deaths occurring in this cohort. Among 19,103 kidney transplant procedures analyzed (median follow-up 4.4 years), 2085 deaths occurred, of which 376 (18.0%) were due to malignancy (crude mortality rate 361 malignancy-related deaths per 100,000 person-years). Common sites of malignancy-related death were lymphoma (18.4%), followed by lung (17.6%) and renal (9.8%), with 14.1% unspecified. The risk of malignancy-related death increased with age: under 50 (0.8%), 50-59 (2.5%), 60-69 (4.8%), 70-79 (6.5%) and over 80 years (9.1%). Age- and gender-stratified malignancy-related mortality risk difference was higher in the transplant compared with the general population. Cox proportional hazard models identified increased age, pretransplant history of malignancy and deceased-donor kidney transplantation to be independently associated with risk for post-transplant death from malignancy. Thus, malignancy as a cause of post-kidney transplantation death is common and requires heightened surveillance. More... »

PAGES

1395-1403

References to SciGraph publications

  • 2000-04. Cancer incidence in a kidney-transplanted population in TRANSPLANT INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ki.2013.458

    DOI

    http://dx.doi.org/10.1038/ki.2013.458

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026529082

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24257690


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