Host APOL1 genotype is independently associated with proteinuria in HIV infection View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-10

AUTHORS

Michelle M. Estrella, Christina M. Wyatt, C. Leigh Pearce, Man Li, Michael G. Shlipak, Bradley E. Aouizerat, Deborah Gustafson, Mardge H. Cohen, Stephen J. Gange, W. H. Linda Kao, Rulan S. Parekh

ABSTRACT

Proteinuria is associated with adverse clinical outcomes in HIV infection. Here we evaluated whether APOL1 risk alleles, previously associated with advanced kidney disease, are independently associated with proteinuria in HIV infection in a cross-sectional study of HIV-infected women in the Women's Interagency HIV Study. We estimated the percent difference in urine protein excretion and odds of proteinuria (≥200 mg/g) associated with two versus one or no APOL1 risk allele using linear and logistic regression, respectively. Of 1285 women successfully genotyped, 379 carried one and 80 carried two risk alleles. Proteinuria was present in 124 women, 78 of whom had proteinuria confirmed on a second sample. In women without prior AIDS, two risk alleles were independently associated with a 69% higher urine protein excretion (95% confidence interval (CI): 36, 108) and five-fold higher odds of proteinuria (95% CI: 2.45, 10.37) as compared with one or no risk allele. No association was found in women with prior AIDS. Analyses in which women with impaired kidney function were excluded and proteinuria was confirmed by a second urine sample yielded similar estimates. Thus, APOL1 risk alleles are associated with significant proteinuria in HIV-infected persons without prior clinical AIDS, independent of clinical factors traditionally associated with proteinuria. Trials are needed to determine whether APOL1 genotyping identifies individuals who could benefit from earlier intervention to prevent overt renal disease. More... »

PAGES

834-840

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2013.203

DOI

http://dx.doi.org/10.1038/ki.2013.203

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1047268614

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23715117


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