CD4+ Th1 cells are effectors in lupus nephritis—but what are their targets? View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-11

AUTHORS

Joshua D Ooi, A Richard Kitching

ABSTRACT

Lupus nephritis involves both humoral and cellular effectors. Okamoto and colleagues isolated renal CD4+ cells from lupus-prone mice, selecting cells expressing T-cell receptors on the basis of their activity. After transfecting CD4+ cells with the relevant T-cell receptors, they transferred them into mice and induced more severe glomerulonephritis. This study supports a direct role for Th1 cells in lupus nephritis, although their antigenic specificity remains uncertain, as they did not recognize nucleosomes. More... »

PAGES

947-949

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2012.254

DOI

http://dx.doi.org/10.1038/ki.2012.254

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022546407

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23064187


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