Markers of inflammation predict the long-term risk of developing chronic kidney disease: a population-based cohort study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Anoop Shankar, Liping Sun, Barbara E K Klein, Kristine E Lee, Paul Muntner, F Javier Nieto, Michael Y Tsai, Karen J Cruickshanks, Carla R Schubert, Peter C Brazy, Josef Coresh, Ronald Klein

ABSTRACT

In animal models, inflammatory processes have been shown to have an important role in the development of kidney disease. In humans, however, the independent relation between markers of inflammation and the risk of chronic kidney disease (CKD) is not known. To clarify this, we examined the relationship of several inflammatory biomarker levels (high-sensitivity C-reactive protein, tumor necrosis factor-α receptor 2, white blood cell count, and interleukin-6) with the risk of developing CKD in a population-based cohort of up to 4926 patients with 15 years of follow-up. In cross-sectional analyses, we found that all these inflammation markers were positively associated with the outcome of interest, prevalent CKD. However, in longitudinal analyses examining the risk of developing incident CKD among those who were CKD-free at baseline, only tumor necrosis factor-α receptor 2, white blood cell count, and interleukin-6 levels (hazard ratios comparing highest with the lowest tertile of 2.10, 1.90, and 1.45, respectively), and not C-reactive protein (hazard ratio 1.09), were positively associated with incident CKD. Thus, elevations of most markers of inflammation predict the risk of developing CKD. Each marker should be independently verified. More... »

PAGES

1231-1238

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2011.283

DOI

http://dx.doi.org/10.1038/ki.2011.283

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042452335

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21866089


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