Time course of the antiproteinuric and antihypertensive effects of direct renin inhibition in type 2 diabetes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-06

AUTHORS

F Persson, P Rossing, K J Schjoedt, T Juhl, L Tarnow, C D A Stehouwer, C Schalkwijk, F Boomsma, E Frandsen, H-H Parving

ABSTRACT

Inhibition of renin with an active site inhibitor, aliskiren, lowers blood pressure (BP) in diabetic patients. Here, we studied the time course of the antihypertensive and antiproteinuric effect of renin inhibition in 15 patients with type 2 diabetes and elevated urinary albumin/creatinine ratios (UACRs) to check whether aliskiren can decrease proteinuria. After a 4-week washout of previous medications, patients received aliskiren and furosemide daily for 28 days followed by a 4-week withdrawal period. Twenty-four-hour BPs were measured at baseline throughout treatment and withdrawal periods. The UACR was significantly reduced after 2-4 days of treatment with another significant reduction after 28 days. Systolic blood pressure (SBP) was significantly lower after 7 days with no further reduction after 28 days. The BP returned toward baseline 3 days after withdrawal, whereas the UACR was still significantly reduced compared with baseline 12 days after withdrawal. Our study shows that aliskiren reduced 24 h SBP, and this was associated with a reduction in albuminuria in type 2 diabetic patients. More... »

PAGES

1419-1425

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2008.68

DOI

http://dx.doi.org/10.1038/ki.2008.68

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005143548

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18337712


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