Oral active vitamin D is associated with improved survival in hemodialysis patients View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-10

AUTHORS

Manuel Naves-Díaz, Daniel Álvarez-Hernández, Jutta Passlick-Deetjen, Adrian Guinsburg, Cristina Marelli, Diego Rodriguez-Puyol, Jorge B Cannata-Andía

ABSTRACT

Injection of active vitamin D is associated with better survival of patients receiving chronic hemodialysis. Since in many countries oral active vitamin D administration is the most common form of treatment for secondary hyperparathyroidism we determined the survival benefit of oral active vitamin D in hemodialysis patients from six Latin America countries (FME Register as part of the CORES study) followed for a median of 16 months. Time-dependent Cox regression models, after adjustment for potential confounders, showed that the 7,203 patients who received oral active vitamin D had significant reductions in overall, cardiovascular, infectious and neoplastic mortality compared to the 8,801 patients that had not received vitamin D. Stratified analyses found a survival advantage in the group that had received oral active vitamin D in 36 of the 37 strata studied including that with the highest levels of serum calcium, phosphorus and parathyroid hormone. The survival benefit of oral active vitamin D was seen in those patients receiving mean daily doses of less than 1 microg with the highest reduction associated with the lowest dose. Our study shows that hemodialysis patients receiving oral active vitamin D had a survival advantage inversely related to the vitamin dose. More... »

PAGES

1070-1078

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.2008.343

DOI

http://dx.doi.org/10.1038/ki.2008.343

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1037325725

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18633342


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