Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-11

AUTHORS

L A Haseley, J J Wisnieski, M R Denburg, A R Michael-Grossman, E M Ginzler, M F Gourley, J H Hoffman, R P Kimberly, J E Salmon

ABSTRACT

Autoantibodies to the collagen-like region of the first complement component (C1qAB) are found in patients with systemic lupus erythematosus (SLE), particularly those with renal disease. In a cohort of 46 SLE patients with diffuse proliferative glomerulonephritis, we found declining C1qAB titers in 77% of treatment responders and in only 38% of treatment non-responders (P < 0.03). To further characterize this autoantibody, we tested 240 SLE patients for the presence of C1qAB. Positive titers were found in 44% of patients with renal disease and 18% of patients without renal disease (chi2 P < 0.0003). Analysis of IgG subclass revealed IgG2 C1qAB alone in 34%, IgG1 C1qAB alone in 20%, and both IgG1 and IgG2 in 46% of patients. Fewer than 10% of patients had measurable titers of IgG3 or IgG4 C1qAB. The pathogenic role of these IgG2-skewed C1qAB may relate to impaired immune complex clearance by the mononuclear phagocyte system: IgG2 antibodies are efficiently recognized by only one IgG receptor, the H131 allele of Fc gamma RIIa (Fc gamma RIIa-H131). In contrast, Fc gamma RIIa-R131, which is characterized by minimal IgG2 binding, has recently been associated with lupus nephritis. In our C1qAB positive patients, the presence of Fc gamma RIIA-R131 was associated with an increased risk for renal disease. Autoantibodies to C1q may have pathogenic significance in SLE patients with genetic defects in the ability to clear IgG2 containing immune complexes. More... »

PAGES

1375-1380

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1997.464

DOI

http://dx.doi.org/10.1038/ki.1997.464

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1035565766

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/9350662


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement C1q", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cross-Sectional Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Longitudinal Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lupus Erythematosus, Systemic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, IgG", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Hospital for Special Surgery", 
          "id": "https://www.grid.ac/institutes/grid.239915.5", 
          "name": [
            "Department of Medicine, Hospital for Special Surgery, Cornell University Medical College, New York, New York, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Haseley", 
        "givenName": "L A", 
        "type": "Person"
      }, 
      {
        "familyName": "Wisnieski", 
        "givenName": "J J", 
        "type": "Person"
      }, 
      {
        "familyName": "Denburg", 
        "givenName": "M R", 
        "type": "Person"
      }, 
      {
        "familyName": "Michael-Grossman", 
        "givenName": "A R", 
        "type": "Person"
      }, 
      {
        "familyName": "Ginzler", 
        "givenName": "E M", 
        "id": "sg:person.01215267066.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215267066.51"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Gourley", 
        "givenName": "M F", 
        "id": "sg:person.01053535447.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053535447.60"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hoffman", 
        "givenName": "J H", 
        "type": "Person"
      }, 
      {
        "familyName": "Kimberly", 
        "givenName": "R P", 
        "id": "sg:person.01304356355.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304356355.83"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Salmon", 
        "givenName": "J E", 
        "id": "sg:person.0762075040.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762075040.68"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1006/clin.1993.1066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000111964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115712", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002865800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.61", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007838544", 
          "https://doi.org/10.1038/ki.1989.61"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0272-6386(95)90595-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009461516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-1229(92)90097-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010519453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780310401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010992112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anr.1780320506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012800939"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780380303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012865343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113684", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013266736"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0090-1229(05)80030-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015756382"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1997.32", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016625814", 
          "https://doi.org/10.1038/ki.1997.32"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anr.1780320910", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026311108"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02918613", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026705982", 
          "https://doi.org/10.1007/bf02918613"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci118552", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028089863"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005792-198703000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029203038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005792-198703000-00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029203038"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(12)80997-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030625013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.1995.tb03583.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033008086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.52.12.851", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037006183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2249.1996.33740.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037126415"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780381217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039116528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/anr.1780321216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042259964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90299-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043337964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(94)90299-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043337964"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.433", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043452025", 
          "https://doi.org/10.1038/ki.1992.433"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/83.4.415", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046403791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780331107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047905573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/art.1780251101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051582030"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-8411(88)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052481337"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052765763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/096120339600500309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/096120339600500309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/096120339600500309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063903911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-125-7-199610010-00003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073700878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-97-5-801_2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073740025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076895131", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077614582", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077977398", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078061877", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079813046", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081632794", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081689489", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082242347", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-11", 
    "datePublishedReg": "1997-11-01", 
    "description": "Autoantibodies to the collagen-like region of the first complement component (C1qAB) are found in patients with systemic lupus erythematosus (SLE), particularly those with renal disease. In a cohort of 46 SLE patients with diffuse proliferative glomerulonephritis, we found declining C1qAB titers in 77% of treatment responders and in only 38% of treatment non-responders (P < 0.03). To further characterize this autoantibody, we tested 240 SLE patients for the presence of C1qAB. Positive titers were found in 44% of patients with renal disease and 18% of patients without renal disease (chi2 P < 0.0003). Analysis of IgG subclass revealed IgG2 C1qAB alone in 34%, IgG1 C1qAB alone in 20%, and both IgG1 and IgG2 in 46% of patients. Fewer than 10% of patients had measurable titers of IgG3 or IgG4 C1qAB. The pathogenic role of these IgG2-skewed C1qAB may relate to impaired immune complex clearance by the mononuclear phagocyte system: IgG2 antibodies are efficiently recognized by only one IgG receptor, the H131 allele of Fc gamma RIIa (Fc gamma RIIa-H131). In contrast, Fc gamma RIIa-R131, which is characterized by minimal IgG2 binding, has recently been associated with lupus nephritis. In our C1qAB positive patients, the presence of Fc gamma RIIA-R131 was associated with an increased risk for renal disease. Autoantibodies to C1q may have pathogenic significance in SLE patients with genetic defects in the ability to clear IgG2 containing immune complexes.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1997.464", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2462924", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "52"
      }
    ], 
    "name": "Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to Fc\u03b3RIIA alleles", 
    "pagination": "1375-1380", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a96ba6c692c70582809a73cad2a1de4477d7c0baf25231c6dabea313c073b140"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "9350662"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1997.464"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1035565766"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1997.464", 
      "https://app.dimensions.ai/details/publication/pub.1035565766"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:48", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v52/n5/abs/ki1997464a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.464'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.464'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.464'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.464'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      82 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1997.464 schema:about N03543413f3824c129fad0abdb4035f82
2 N06e6421ef2374a77922688e92ff05bdd
3 N14fdc4d37ebb44648e1290ad454ebdc3
4 N2d3f684aa3c94bac92e19c91f58e40bf
5 N302b5a8107d74a07aa5867fd4d03fba2
6 N351f55d5b4624e56871e65b711452b54
7 N429f3c68a54e49a99ec7f447cfaf97aa
8 N4522e4d33dca45bdbefe0cbf8fad4bf5
9 N5c17e480cc564c07a6356a1cfaa98d0a
10 N66578acaf7fc44f7a6fac61f6fb902cb
11 N6c691d728bcb4ecc97b1175830491b04
12 Na867b2281c8f4fb4971c6e7a267c1b34
13 Ncff076128ca242bca9c990d3d68d79b8
14 Nf54fe02b67ea46218f36d4a677cf42c3
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author Nd85c7cb5b490497ab02ba9e1e17180bf
18 schema:citation sg:pub.10.1007/bf02918613
19 sg:pub.10.1038/ki.1989.61
20 sg:pub.10.1038/ki.1992.433
21 sg:pub.10.1038/ki.1997.32
22 https://app.dimensions.ai/details/publication/pub.1076895131
23 https://app.dimensions.ai/details/publication/pub.1077614582
24 https://app.dimensions.ai/details/publication/pub.1077977398
25 https://app.dimensions.ai/details/publication/pub.1078061877
26 https://app.dimensions.ai/details/publication/pub.1079813046
27 https://app.dimensions.ai/details/publication/pub.1081632794
28 https://app.dimensions.ai/details/publication/pub.1081689489
29 https://app.dimensions.ai/details/publication/pub.1082242347
30 https://doi.org/10.1002/anr.1780320506
31 https://doi.org/10.1002/anr.1780320910
32 https://doi.org/10.1002/anr.1780321216
33 https://doi.org/10.1002/art.1780251101
34 https://doi.org/10.1002/art.1780310401
35 https://doi.org/10.1002/art.1780331107
36 https://doi.org/10.1002/art.1780380303
37 https://doi.org/10.1002/art.1780381217
38 https://doi.org/10.1006/clin.1993.1066
39 https://doi.org/10.1016/0022-1759(94)90299-2
40 https://doi.org/10.1016/0090-1229(92)90097-8
41 https://doi.org/10.1016/0272-6386(95)90595-2
42 https://doi.org/10.1016/0896-8411(88)90069-8
43 https://doi.org/10.1016/s0090-1229(05)80030-3
44 https://doi.org/10.1016/s0272-6386(12)80997-8
45 https://doi.org/10.1046/j.1365-2249.1996.33740.x
46 https://doi.org/10.1093/ajcp/83.4.415
47 https://doi.org/10.1097/00005792-198703000-00001
48 https://doi.org/10.1111/j.1365-3083.1995.tb03583.x
49 https://doi.org/10.1136/ard.52.12.851
50 https://doi.org/10.1172/jci113684
51 https://doi.org/10.1172/jci115712
52 https://doi.org/10.1172/jci116022
53 https://doi.org/10.1172/jci118552
54 https://doi.org/10.1177/096120339600500309
55 https://doi.org/10.7326/0003-4819-125-7-199610010-00003
56 https://doi.org/10.7326/0003-4819-97-5-801_2
57 schema:datePublished 1997-11
58 schema:datePublishedReg 1997-11-01
59 schema:description Autoantibodies to the collagen-like region of the first complement component (C1qAB) are found in patients with systemic lupus erythematosus (SLE), particularly those with renal disease. In a cohort of 46 SLE patients with diffuse proliferative glomerulonephritis, we found declining C1qAB titers in 77% of treatment responders and in only 38% of treatment non-responders (P < 0.03). To further characterize this autoantibody, we tested 240 SLE patients for the presence of C1qAB. Positive titers were found in 44% of patients with renal disease and 18% of patients without renal disease (chi2 P < 0.0003). Analysis of IgG subclass revealed IgG2 C1qAB alone in 34%, IgG1 C1qAB alone in 20%, and both IgG1 and IgG2 in 46% of patients. Fewer than 10% of patients had measurable titers of IgG3 or IgG4 C1qAB. The pathogenic role of these IgG2-skewed C1qAB may relate to impaired immune complex clearance by the mononuclear phagocyte system: IgG2 antibodies are efficiently recognized by only one IgG receptor, the H131 allele of Fc gamma RIIa (Fc gamma RIIa-H131). In contrast, Fc gamma RIIa-R131, which is characterized by minimal IgG2 binding, has recently been associated with lupus nephritis. In our C1qAB positive patients, the presence of Fc gamma RIIA-R131 was associated with an increased risk for renal disease. Autoantibodies to C1q may have pathogenic significance in SLE patients with genetic defects in the ability to clear IgG2 containing immune complexes.
60 schema:genre research_article
61 schema:inLanguage en
62 schema:isAccessibleForFree true
63 schema:isPartOf N4031d694d7a14d1292c0174d7f1e8cd3
64 N40faecb856c3497f96cf484207f2e0f0
65 sg:journal.1015319
66 schema:name Antibodies to C1q in systemic lupus erythematosus: Characteristics and relation to FcγRIIA alleles
67 schema:pagination 1375-1380
68 schema:productId N404a2b1d655b4f64a82e0d6f685abed9
69 N425f7ad12f1a4694bc8cc15d123bcf6b
70 N6fc85263f4434666820bbbfacbe9fca7
71 Na65be53bd9564910ba5e4a2c46732068
72 Nfef716144eb24914b204ba09c8f6a93a
73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035565766
74 https://doi.org/10.1038/ki.1997.464
75 schema:sdDatePublished 2019-04-10T14:48
76 schema:sdLicense https://scigraph.springernature.com/explorer/license/
77 schema:sdPublisher N7b84b34cd09340b3a71e760b5362faea
78 schema:url http://www.nature.com/ki/journal/v52/n5/abs/ki1997464a.html
79 sgo:license sg:explorer/license/
80 sgo:sdDataset articles
81 rdf:type schema:ScholarlyArticle
82 N03543413f3824c129fad0abdb4035f82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Autoantibodies
84 rdf:type schema:DefinedTerm
85 N0485e203df734d61a1393a7fce99cd71 rdf:first sg:person.0762075040.68
86 rdf:rest rdf:nil
87 N06e6421ef2374a77922688e92ff05bdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Alleles
89 rdf:type schema:DefinedTerm
90 N14fdc4d37ebb44648e1290ad454ebdc3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Lupus Erythematosus, Systemic
92 rdf:type schema:DefinedTerm
93 N182be17d343b4b1bad36e0525fe6c692 schema:familyName Hoffman
94 schema:givenName J H
95 rdf:type schema:Person
96 N184e6f63c1f2476fbecc62aa0766eb4f rdf:first sg:person.01304356355.83
97 rdf:rest N0485e203df734d61a1393a7fce99cd71
98 N1e4d9e64368a4c908947bf1c67d39a38 schema:familyName Michael-Grossman
99 schema:givenName A R
100 rdf:type schema:Person
101 N2d3f684aa3c94bac92e19c91f58e40bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N302b5a8107d74a07aa5867fd4d03fba2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Adult
106 rdf:type schema:DefinedTerm
107 N351f55d5b4624e56871e65b711452b54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Longitudinal Studies
109 rdf:type schema:DefinedTerm
110 N4031d694d7a14d1292c0174d7f1e8cd3 schema:volumeNumber 52
111 rdf:type schema:PublicationVolume
112 N404a2b1d655b4f64a82e0d6f685abed9 schema:name pubmed_id
113 schema:value 9350662
114 rdf:type schema:PropertyValue
115 N40faecb856c3497f96cf484207f2e0f0 schema:issueNumber 5
116 rdf:type schema:PublicationIssue
117 N425f7ad12f1a4694bc8cc15d123bcf6b schema:name dimensions_id
118 schema:value pub.1035565766
119 rdf:type schema:PropertyValue
120 N429f3c68a54e49a99ec7f447cfaf97aa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N4522e4d33dca45bdbefe0cbf8fad4bf5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cross-Sectional Studies
125 rdf:type schema:DefinedTerm
126 N50b5864b91b1424dafcbff9d222b86d1 rdf:first N182be17d343b4b1bad36e0525fe6c692
127 rdf:rest N184e6f63c1f2476fbecc62aa0766eb4f
128 N566ea7c2884542b4bdf25f8ad2151241 rdf:first N7e3715f96c3f42be95e2f9979bd84181
129 rdf:rest Na0ab7e658f5648f097c9fc0f4b7d7ded
130 N5c17e480cc564c07a6356a1cfaa98d0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Genotype
132 rdf:type schema:DefinedTerm
133 N66578acaf7fc44f7a6fac61f6fb902cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Aged
135 rdf:type schema:DefinedTerm
136 N6c691d728bcb4ecc97b1175830491b04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Middle Aged
138 rdf:type schema:DefinedTerm
139 N6fc85263f4434666820bbbfacbe9fca7 schema:name doi
140 schema:value 10.1038/ki.1997.464
141 rdf:type schema:PropertyValue
142 N709628d877134f1d932eb729e2d503a0 rdf:first N7c6afe7ba21b4d8d84a5ce69887e9089
143 rdf:rest N566ea7c2884542b4bdf25f8ad2151241
144 N7b84b34cd09340b3a71e760b5362faea schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N7c6afe7ba21b4d8d84a5ce69887e9089 schema:familyName Wisnieski
147 schema:givenName J J
148 rdf:type schema:Person
149 N7e3715f96c3f42be95e2f9979bd84181 schema:familyName Denburg
150 schema:givenName M R
151 rdf:type schema:Person
152 N9490285d155f446ebfbe0d2d5aa5d690 rdf:first sg:person.01215267066.51
153 rdf:rest Ncd8221b80dff43d49a3897069aaafed9
154 Na0ab7e658f5648f097c9fc0f4b7d7ded rdf:first N1e4d9e64368a4c908947bf1c67d39a38
155 rdf:rest N9490285d155f446ebfbe0d2d5aa5d690
156 Na65be53bd9564910ba5e4a2c46732068 schema:name nlm_unique_id
157 schema:value 0323470
158 rdf:type schema:PropertyValue
159 Na867b2281c8f4fb4971c6e7a267c1b34 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Complement C1q
161 rdf:type schema:DefinedTerm
162 Nc359a5e136524fffac957f5fed1749db schema:affiliation https://www.grid.ac/institutes/grid.239915.5
163 schema:familyName Haseley
164 schema:givenName L A
165 rdf:type schema:Person
166 Ncd8221b80dff43d49a3897069aaafed9 rdf:first sg:person.01053535447.60
167 rdf:rest N50b5864b91b1424dafcbff9d222b86d1
168 Ncff076128ca242bca9c990d3d68d79b8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Male
170 rdf:type schema:DefinedTerm
171 Nd85c7cb5b490497ab02ba9e1e17180bf rdf:first Nc359a5e136524fffac957f5fed1749db
172 rdf:rest N709628d877134f1d932eb729e2d503a0
173 Nf54fe02b67ea46218f36d4a677cf42c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Receptors, IgG
175 rdf:type schema:DefinedTerm
176 Nfef716144eb24914b204ba09c8f6a93a schema:name readcube_id
177 schema:value a96ba6c692c70582809a73cad2a1de4477d7c0baf25231c6dabea313c073b140
178 rdf:type schema:PropertyValue
179 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
180 schema:name Medical and Health Sciences
181 rdf:type schema:DefinedTerm
182 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
183 schema:name Immunology
184 rdf:type schema:DefinedTerm
185 sg:grant.2462924 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.1997.464
186 rdf:type schema:MonetaryGrant
187 sg:journal.1015319 schema:issn 0085-2538
188 1523-1755
189 schema:name Kidney International
190 rdf:type schema:Periodical
191 sg:person.01053535447.60 schema:familyName Gourley
192 schema:givenName M F
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053535447.60
194 rdf:type schema:Person
195 sg:person.01215267066.51 schema:familyName Ginzler
196 schema:givenName E M
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215267066.51
198 rdf:type schema:Person
199 sg:person.01304356355.83 schema:familyName Kimberly
200 schema:givenName R P
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304356355.83
202 rdf:type schema:Person
203 sg:person.0762075040.68 schema:familyName Salmon
204 schema:givenName J E
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762075040.68
206 rdf:type schema:Person
207 sg:pub.10.1007/bf02918613 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026705982
208 https://doi.org/10.1007/bf02918613
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/ki.1989.61 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007838544
211 https://doi.org/10.1038/ki.1989.61
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ki.1992.433 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043452025
214 https://doi.org/10.1038/ki.1992.433
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ki.1997.32 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016625814
217 https://doi.org/10.1038/ki.1997.32
218 rdf:type schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1076895131 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1077614582 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1077977398 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1078061877 schema:CreativeWork
223 https://app.dimensions.ai/details/publication/pub.1079813046 schema:CreativeWork
224 https://app.dimensions.ai/details/publication/pub.1081632794 schema:CreativeWork
225 https://app.dimensions.ai/details/publication/pub.1081689489 schema:CreativeWork
226 https://app.dimensions.ai/details/publication/pub.1082242347 schema:CreativeWork
227 https://doi.org/10.1002/anr.1780320506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012800939
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1002/anr.1780320910 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026311108
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1002/anr.1780321216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042259964
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1002/art.1780251101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051582030
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1002/art.1780310401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010992112
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1002/art.1780331107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047905573
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1002/art.1780380303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012865343
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1002/art.1780381217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039116528
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1006/clin.1993.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000111964
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/0022-1759(94)90299-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043337964
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/0090-1229(92)90097-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010519453
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0272-6386(95)90595-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009461516
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0896-8411(88)90069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052481337
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/s0090-1229(05)80030-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015756382
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/s0272-6386(12)80997-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030625013
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1046/j.1365-2249.1996.33740.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1037126415
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1093/ajcp/83.4.415 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046403791
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1097/00005792-198703000-00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029203038
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1111/j.1365-3083.1995.tb03583.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1033008086
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1136/ard.52.12.851 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037006183
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1172/jci113684 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013266736
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1172/jci115712 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002865800
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1172/jci116022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052765763
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1172/jci118552 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028089863
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1177/096120339600500309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063903911
276 rdf:type schema:CreativeWork
277 https://doi.org/10.7326/0003-4819-125-7-199610010-00003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073700878
278 rdf:type schema:CreativeWork
279 https://doi.org/10.7326/0003-4819-97-5-801_2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073740025
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.239915.5 schema:alternateName Hospital for Special Surgery
282 schema:name Department of Medicine, Hospital for Special Surgery, Cornell University Medical College, New York, New York, USA.
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...