Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-01

AUTHORS

Xiao-Ru Huang, Peter G Tipping, Li Shuo, Stephen R Holdsworth

ABSTRACT

The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent. More... »

PAGES

94-103

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1997.12

DOI

http://dx.doi.org/10.1038/ki.1997.12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022776985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8995722


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement System Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creatinine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globulins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypersensitivity, Delayed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulins, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteinuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Helper-Inducer", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Xiao-Ru", 
        "id": "sg:person.01233272432.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tipping", 
        "givenName": "Peter G", 
        "id": "sg:person.0661674330.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shuo", 
        "givenName": "Li", 
        "type": "Person"
      }, 
      {
        "familyName": "Holdsworth", 
        "givenName": "Stephen R", 
        "id": "sg:person.01131260677.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ki.1985.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002107889", 
          "https://doi.org/10.1038/ki.1985.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00914967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003273042", 
          "https://doi.org/10.1007/bf00914967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006373571", 
          "https://doi.org/10.1038/ki.1994.246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1979.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006561866", 
          "https://doi.org/10.1038/ki.1979.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830250103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007802347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008590465", 
          "https://doi.org/10.1038/ki.1988.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013498862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.159.5.1560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014111265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023607228", 
          "https://doi.org/10.1038/ki.1987.288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(95)80068-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024359708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025518790", 
          "https://doi.org/10.1038/ki.1987.123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60652-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028361542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360728", 
          "https://doi.org/10.1038/ki.1992.221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830250508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034245991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.162.3.1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037768219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(94)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039226332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(94)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039226332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-8411(91)90021-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041135273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.161.2.378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043103548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1979.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045525616", 
          "https://doi.org/10.1038/ki.1979.116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.148.1.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047255809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830260228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050112857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319567", 
          "https://doi.org/10.1038/ki.1986.239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487393", 
          "https://doi.org/10.1038/ki.1994.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078897020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078937839", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078986202", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079473991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079482704", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079561258", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079922532", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082473596", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082570130", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-01", 
    "datePublishedReg": "1997-01-01", 
    "description": "The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1997.12", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "name": "Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice", 
    "pagination": "94-103", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6c83cea7dbb5b8b36c6191300608a74ccf39a6d55c479db9c7a45393e71e6926"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8995722"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1997.12"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022776985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1997.12", 
      "https://app.dimensions.ai/details/publication/pub.1022776985"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v51/n1/full/ki199712a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      84 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1997.12 schema:about N08c4037b6ea348db94a4287bfa09f13d
2 N0bcb7ce2a3ff46c7b15f0407505048f7
3 N0dc2a4d96d1c44288062b1de928fc606
4 N1234ecc9f1c34811b3a29bab452ea7f7
5 N32a79946a084450798bbf80f65b4f154
6 N37b3fecfdf5c4a82b89c33261b4697a8
7 N5873d324a0bb4faf9ef405523e1cebb1
8 N69a8ec1d0ce843a8bef736b91a127e60
9 N6a768720345d4613b9cf3978bf615be3
10 N743cefe1db974b839fd4733b1feef446
11 N77976f422fbd46dd8c872773fc35bbe9
12 N7a3d80813ad34632a5d2ebad95852c5a
13 N8a15b6505b4440518d92d2ce84a68422
14 Na2c5e9248d884f4ab360e4e5cd46fdd6
15 Nb9cf7ce736064d5bb8c7f9400583ba62
16 Ndc4ac4879f054c9faa6b961a5906216d
17 Ndfec0715b5964e6b8f1f7ba9b67303b1
18 Ne1c66c7d2ee741959a29c74383aa4b5c
19 Ne61e9d98aa4b460192897db775431aef
20 Nf9666ba680784159ad5f9364137103ea
21 anzsrc-for:11
22 anzsrc-for:1107
23 schema:author N005dd6c3f5a746b2b3506fbfcba67a4c
24 schema:citation sg:pub.10.1007/bf00914967
25 sg:pub.10.1038/ki.1979.116
26 sg:pub.10.1038/ki.1979.24
27 sg:pub.10.1038/ki.1985.43
28 sg:pub.10.1038/ki.1986.239
29 sg:pub.10.1038/ki.1987.123
30 sg:pub.10.1038/ki.1987.288
31 sg:pub.10.1038/ki.1988.224
32 sg:pub.10.1038/ki.1992.221
33 sg:pub.10.1038/ki.1994.245
34 sg:pub.10.1038/ki.1994.246
35 https://app.dimensions.ai/details/publication/pub.1078897020
36 https://app.dimensions.ai/details/publication/pub.1078937839
37 https://app.dimensions.ai/details/publication/pub.1078986202
38 https://app.dimensions.ai/details/publication/pub.1079473991
39 https://app.dimensions.ai/details/publication/pub.1079482704
40 https://app.dimensions.ai/details/publication/pub.1079561258
41 https://app.dimensions.ai/details/publication/pub.1079922532
42 https://app.dimensions.ai/details/publication/pub.1082473596
43 https://app.dimensions.ai/details/publication/pub.1082570130
44 https://doi.org/10.1002/eji.1830250103
45 https://doi.org/10.1002/eji.1830250508
46 https://doi.org/10.1002/eji.1830260228
47 https://doi.org/10.1016/0003-2697(76)90527-3
48 https://doi.org/10.1016/0165-5728(94)90069-8
49 https://doi.org/10.1016/0167-5699(95)80068-9
50 https://doi.org/10.1016/0896-8411(91)90021-4
51 https://doi.org/10.1016/s0065-2776(08)60652-5
52 https://doi.org/10.1016/s0140-6736(88)90413-8
53 https://doi.org/10.1084/jem.148.1.246
54 https://doi.org/10.1084/jem.159.5.1560
55 https://doi.org/10.1084/jem.161.2.378
56 https://doi.org/10.1084/jem.162.3.1105
57 https://doi.org/10.1084/jem.169.1.59
58 https://doi.org/10.1172/jci115055
59 schema:datePublished 1997-01
60 schema:datePublishedReg 1997-01-01
61 schema:description The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N727eb487d06e447bbb88aad0ea6882bb
66 Nac9ef8e9fe8b43dc95a2626c9b79f04f
67 sg:journal.1015319
68 schema:name Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice
69 schema:pagination 94-103
70 schema:productId N3842d6f73ca340deb79962abd88cae00
71 N4ed3945b15a040929294a45fa84a8f88
72 N5067c02957aa4f1fa29d8ceda4253f4d
73 Nc53bcb81ac974fe38456a8369b04d832
74 Nf157cc63e59d404fb574d0f35d89812a
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022776985
76 https://doi.org/10.1038/ki.1997.12
77 schema:sdDatePublished 2019-04-10T16:29
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N03f022ff14554d60a6a0db601a86c4c2
80 schema:url http://www.nature.com/ki/journal/v51/n1/full/ki199712a.html
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N005dd6c3f5a746b2b3506fbfcba67a4c rdf:first sg:person.01233272432.56
85 rdf:rest N0ad1b50bfc704978991d8e5db559cf89
86 N03f022ff14554d60a6a0db601a86c4c2 schema:name Springer Nature - SN SciGraph project
87 rdf:type schema:Organization
88 N08c4037b6ea348db94a4287bfa09f13d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Creatinine
90 rdf:type schema:DefinedTerm
91 N0ad1b50bfc704978991d8e5db559cf89 rdf:first sg:person.0661674330.39
92 rdf:rest Nfde820a511624b3a892c810b14a5852e
93 N0bcb7ce2a3ff46c7b15f0407505048f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Antigens
95 rdf:type schema:DefinedTerm
96 N0dc2a4d96d1c44288062b1de928fc606 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Immunoglobulin G
98 rdf:type schema:DefinedTerm
99 N1234ecc9f1c34811b3a29bab452ea7f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Animals
101 rdf:type schema:DefinedTerm
102 N32a79946a084450798bbf80f65b4f154 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mice, Inbred C57BL
104 rdf:type schema:DefinedTerm
105 N37b3fecfdf5c4a82b89c33261b4697a8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Complement System Proteins
107 rdf:type schema:DefinedTerm
108 N3842d6f73ca340deb79962abd88cae00 schema:name pubmed_id
109 schema:value 8995722
110 rdf:type schema:PropertyValue
111 N4ed3945b15a040929294a45fa84a8f88 schema:name nlm_unique_id
112 schema:value 0323470
113 rdf:type schema:PropertyValue
114 N5067c02957aa4f1fa29d8ceda4253f4d schema:name dimensions_id
115 schema:value pub.1022776985
116 rdf:type schema:PropertyValue
117 N5873d324a0bb4faf9ef405523e1cebb1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Immunoglobulins, Intravenous
119 rdf:type schema:DefinedTerm
120 N69a8ec1d0ce843a8bef736b91a127e60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Autoantibodies
122 rdf:type schema:DefinedTerm
123 N6a768720345d4613b9cf3978bf615be3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mice
125 rdf:type schema:DefinedTerm
126 N727eb487d06e447bbb88aad0ea6882bb schema:issueNumber 1
127 rdf:type schema:PublicationIssue
128 N743cefe1db974b839fd4733b1feef446 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Sheep
130 rdf:type schema:DefinedTerm
131 N756bd621eb3a4f15b6de478ca9a3ef5e rdf:first sg:person.01131260677.45
132 rdf:rest rdf:nil
133 N77976f422fbd46dd8c872773fc35bbe9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Proteinuria
135 rdf:type schema:DefinedTerm
136 N7a3d80813ad34632a5d2ebad95852c5a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Mice, Inbred BALB C
138 rdf:type schema:DefinedTerm
139 N8a15b6505b4440518d92d2ce84a68422 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name CD4 Antigens
141 rdf:type schema:DefinedTerm
142 Na2c5e9248d884f4ab360e4e5cd46fdd6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name T-Lymphocytes, Helper-Inducer
144 rdf:type schema:DefinedTerm
145 Nac9ef8e9fe8b43dc95a2626c9b79f04f schema:volumeNumber 51
146 rdf:type schema:PublicationVolume
147 Nb9cf7ce736064d5bb8c7f9400583ba62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Glomerulonephritis
149 rdf:type schema:DefinedTerm
150 Nc53bcb81ac974fe38456a8369b04d832 schema:name doi
151 schema:value 10.1038/ki.1997.12
152 rdf:type schema:PropertyValue
153 Ndc4ac4879f054c9faa6b961a5906216d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Interferon-gamma
155 rdf:type schema:DefinedTerm
156 Ndfec0715b5964e6b8f1f7ba9b67303b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Hypersensitivity, Delayed
158 rdf:type schema:DefinedTerm
159 Ne1c66c7d2ee741959a29c74383aa4b5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Fibrin
161 rdf:type schema:DefinedTerm
162 Ne2efa83246d6458eafdac6641ce5f5f9 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
163 schema:familyName Shuo
164 schema:givenName Li
165 rdf:type schema:Person
166 Ne61e9d98aa4b460192897db775431aef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Male
168 rdf:type schema:DefinedTerm
169 Nf157cc63e59d404fb574d0f35d89812a schema:name readcube_id
170 schema:value 6c83cea7dbb5b8b36c6191300608a74ccf39a6d55c479db9c7a45393e71e6926
171 rdf:type schema:PropertyValue
172 Nf9666ba680784159ad5f9364137103ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Globulins
174 rdf:type schema:DefinedTerm
175 Nfde820a511624b3a892c810b14a5852e rdf:first Ne2efa83246d6458eafdac6641ce5f5f9
176 rdf:rest N756bd621eb3a4f15b6de478ca9a3ef5e
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
181 schema:name Immunology
182 rdf:type schema:DefinedTerm
183 sg:journal.1015319 schema:issn 0085-2538
184 1523-1755
185 schema:name Kidney International
186 rdf:type schema:Periodical
187 sg:person.01131260677.45 schema:familyName Holdsworth
188 schema:givenName Stephen R
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
190 rdf:type schema:Person
191 sg:person.01233272432.56 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
192 schema:familyName Huang
193 schema:givenName Xiao-Ru
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56
195 rdf:type schema:Person
196 sg:person.0661674330.39 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
197 schema:familyName Tipping
198 schema:givenName Peter G
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39
200 rdf:type schema:Person
201 sg:pub.10.1007/bf00914967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003273042
202 https://doi.org/10.1007/bf00914967
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/ki.1979.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045525616
205 https://doi.org/10.1038/ki.1979.116
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ki.1979.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561866
208 https://doi.org/10.1038/ki.1979.24
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/ki.1985.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002107889
211 https://doi.org/10.1038/ki.1985.43
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ki.1986.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319567
214 https://doi.org/10.1038/ki.1986.239
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ki.1987.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025518790
217 https://doi.org/10.1038/ki.1987.123
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ki.1987.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023607228
220 https://doi.org/10.1038/ki.1987.288
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ki.1988.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008590465
223 https://doi.org/10.1038/ki.1988.224
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ki.1992.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029360728
226 https://doi.org/10.1038/ki.1992.221
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/ki.1994.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487393
229 https://doi.org/10.1038/ki.1994.245
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ki.1994.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006373571
232 https://doi.org/10.1038/ki.1994.246
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1078897020 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1078937839 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1078986202 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079473991 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079482704 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1079561258 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1079922532 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082473596 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082570130 schema:CreativeWork
243 https://doi.org/10.1002/eji.1830250103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007802347
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/eji.1830250508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343590
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/eji.1830260228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050112857
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0165-5728(94)90069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039226332
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0167-5699(95)80068-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024359708
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0896-8411(91)90021-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041135273
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0065-2776(08)60652-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028361542
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0140-6736(88)90413-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045957451
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1084/jem.148.1.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047255809
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1084/jem.159.5.1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014111265
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1084/jem.161.2.378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043103548
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1084/jem.162.3.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037768219
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1084/jem.169.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034245991
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1172/jci115055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013498862
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
274 schema:name Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...