Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1997-01

AUTHORS

Xiao-Ru Huang, Peter G Tipping, Li Shuo, Stephen R Holdsworth

ABSTRACT

The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent. More... »

PAGES

94-103

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1997.12

DOI

http://dx.doi.org/10.1038/ki.1997.12

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022776985

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8995722


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Autoantibodies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement System Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Creatinine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Globulins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypersensitivity, Delayed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulin G", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoglobulins, Intravenous", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interferon-gamma", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred BALB C", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proteinuria", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sheep", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "T-Lymphocytes, Helper-Inducer", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Xiao-Ru", 
        "id": "sg:person.01233272432.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tipping", 
        "givenName": "Peter G", 
        "id": "sg:person.0661674330.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shuo", 
        "givenName": "Li", 
        "type": "Person"
      }, 
      {
        "familyName": "Holdsworth", 
        "givenName": "Stephen R", 
        "id": "sg:person.01131260677.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ki.1985.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002107889", 
          "https://doi.org/10.1038/ki.1985.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00914967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003273042", 
          "https://doi.org/10.1007/bf00914967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006373571", 
          "https://doi.org/10.1038/ki.1994.246"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1979.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006561866", 
          "https://doi.org/10.1038/ki.1979.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830250103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007802347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008590465", 
          "https://doi.org/10.1038/ki.1988.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci115055", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013498862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.159.5.1560", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014111265"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023607228", 
          "https://doi.org/10.1038/ki.1987.288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-5699(95)80068-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024359708"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025518790", 
          "https://doi.org/10.1038/ki.1987.123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60652-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028361542"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360728", 
          "https://doi.org/10.1038/ki.1992.221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830250508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030343590"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.1.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034245991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.162.3.1105", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037768219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(94)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039226332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0165-5728(94)90069-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039226332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0896-8411(91)90021-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041135273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.161.2.378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043103548"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1979.116", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045525616", 
          "https://doi.org/10.1038/ki.1979.116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(88)90413-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045957451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.148.1.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047255809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830260228", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050112857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319567", 
          "https://doi.org/10.1038/ki.1986.239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1994.245", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053487393", 
          "https://doi.org/10.1038/ki.1994.245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078897020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078937839", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078986202", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079473991", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079482704", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079561258", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079922532", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082473596", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082570130", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1997-01", 
    "datePublishedReg": "1997-01-01", 
    "description": "The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1997.12", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "51"
      }
    ], 
    "name": "Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice", 
    "pagination": "94-103", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6c83cea7dbb5b8b36c6191300608a74ccf39a6d55c479db9c7a45393e71e6926"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8995722"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1997.12"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022776985"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1997.12", 
      "https://app.dimensions.ai/details/publication/pub.1022776985"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v51/n1/full/ki199712a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1997.12'


 

This table displays all metadata directly associated to this object as RDF triples.

275 TRIPLES      21 PREDICATES      84 URIs      41 LITERALS      29 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1997.12 schema:about N2020d25be43d47158d0eb2840b6a7821
2 N2c31c280d7d249ba8fcb8e34e49ee427
3 N2da5cbcf16e14f6889f744a196b992a6
4 N58a77d86c6af40138e48ac6841a3d4ef
5 N5c37b63f436541cea01a7bb69f8db39b
6 N66074bde60fb45a0b2ef891c45659fff
7 N6708309457a4483abb979c4a0b4a37d2
8 N758329eb9c064e58971449ca39a0b617
9 N86395013166341c783ecfd3e860febbc
10 N883c4c2fd90741d98db7ec5d7e5ab031
11 N9e5f940581c04df3a50b30f556fcbf32
12 Na070fc4d316d49e9b8fe9af56ed8a8cd
13 Na5cc49a392554f69b6f8c2370c5f852b
14 Nb2344f9b556244a5925ce53b8ea8edd0
15 Nb2c259e272b4447d91944168a5dd6b57
16 Nb5262dd46464473d8bbcf5abb7f11e65
17 Nbce151a366cb4648a325762bf6233002
18 Nbea8879e479c4cc0a4d1db2862fe59a5
19 Ne1375b9e996d449ca9cec67adaa039b9
20 Nf04ae741c21f4307a35e1ff53081e2b3
21 anzsrc-for:11
22 anzsrc-for:1107
23 schema:author Nec3e2da32181460886467ab7cfa41716
24 schema:citation sg:pub.10.1007/bf00914967
25 sg:pub.10.1038/ki.1979.116
26 sg:pub.10.1038/ki.1979.24
27 sg:pub.10.1038/ki.1985.43
28 sg:pub.10.1038/ki.1986.239
29 sg:pub.10.1038/ki.1987.123
30 sg:pub.10.1038/ki.1987.288
31 sg:pub.10.1038/ki.1988.224
32 sg:pub.10.1038/ki.1992.221
33 sg:pub.10.1038/ki.1994.245
34 sg:pub.10.1038/ki.1994.246
35 https://app.dimensions.ai/details/publication/pub.1078897020
36 https://app.dimensions.ai/details/publication/pub.1078937839
37 https://app.dimensions.ai/details/publication/pub.1078986202
38 https://app.dimensions.ai/details/publication/pub.1079473991
39 https://app.dimensions.ai/details/publication/pub.1079482704
40 https://app.dimensions.ai/details/publication/pub.1079561258
41 https://app.dimensions.ai/details/publication/pub.1079922532
42 https://app.dimensions.ai/details/publication/pub.1082473596
43 https://app.dimensions.ai/details/publication/pub.1082570130
44 https://doi.org/10.1002/eji.1830250103
45 https://doi.org/10.1002/eji.1830250508
46 https://doi.org/10.1002/eji.1830260228
47 https://doi.org/10.1016/0003-2697(76)90527-3
48 https://doi.org/10.1016/0165-5728(94)90069-8
49 https://doi.org/10.1016/0167-5699(95)80068-9
50 https://doi.org/10.1016/0896-8411(91)90021-4
51 https://doi.org/10.1016/s0065-2776(08)60652-5
52 https://doi.org/10.1016/s0140-6736(88)90413-8
53 https://doi.org/10.1084/jem.148.1.246
54 https://doi.org/10.1084/jem.159.5.1560
55 https://doi.org/10.1084/jem.161.2.378
56 https://doi.org/10.1084/jem.162.3.1105
57 https://doi.org/10.1084/jem.169.1.59
58 https://doi.org/10.1172/jci115055
59 schema:datePublished 1997-01
60 schema:datePublishedReg 1997-01-01
61 schema:description The pattern of glomerulonephritis (GN) developing in response to a planted antigen (sheep anti-mouse GBM globulin) was compared in two strains of mice which demonstrated either a predominant Th1 (C57BL/6) or Th2 (BALB/c) response to this antigen. GN was induced with a subnephritogenic i.v. dose of sheep anti-mouse GBM globulin in mice presensitized to sheep globulin. Sensitized C57BL/6 mice showed pronounced cutaneous delayed-type hypersensitivity (DTH) following the challenge with sheep globulin, low titers of circulating anti-sheep globulin antibody and high interferon gamma (IFN-gamma) and low interleukin 4 (IL-4) production by splenic T cells, consistent with a predominant Th1 pattern of immune response. Sensitized BALB/c mice did not develop DTH following cutaneous challenge with sheep globulin, had higher circulating anti-sheep globulin antibody titers, and showed high IL-4 and low IFN gamma production by splenic T cells compared with C57BL/6 mice, consistent with a predominant Th2 response. In C57BL/6 mice, GN developing in response to sheep globulin exhibited a severe crescentic pattern with prominent glomerular T cell and macrophage influx and fibrin deposition. In vivo depletion with a monoclonal anti-CD4 antibody demonstrated that this injury was T helper cell dependent. Treatment with monoclonal anti-mouse IFN gamma antibody significantly reduced glomerular injury and crescent formation and attenuated the cutaneous DTH response. GN induced by the same protocol in BALB/c mice exhibited pronounced glomerular IgG and complement deposition. Crescent formation, fibrin deposition, and glomerular T cell and macrophage infiltration were significantly less than observed in C57BL/6 mice, and injury was not T cell dependent in the effector phase. These data suggest that the pattern of glomerular injury induced by a planted antigen can be determined by the balance of T helper cell subset activation. A Th1 response induces a severe crescentic pattern of GN, which like cutaneous DTH, is T helper cell and IFN gamma dependent.
62 schema:genre research_article
63 schema:inLanguage en
64 schema:isAccessibleForFree true
65 schema:isPartOf N0b0f8de2edb44ed0a58b150fae07e36d
66 N6aca4395228e4329971931db1472bc1b
67 sg:journal.1015319
68 schema:name Th1 responsiveness to nephritogenic antigens determines susceptibility to crescentic glomerulonephritis in mice
69 schema:pagination 94-103
70 schema:productId N1d4675e5f75b45f296b8a07c748a106b
71 N665c55ebf92d4fc2b41504b3b95db8fb
72 N83f9a3f058bf480782270b347163c0b2
73 Na9faa24352d747528ec2321bc45dce8f
74 Nf4ef5037174341ffa431a1738af3b3f3
75 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022776985
76 https://doi.org/10.1038/ki.1997.12
77 schema:sdDatePublished 2019-04-10T16:29
78 schema:sdLicense https://scigraph.springernature.com/explorer/license/
79 schema:sdPublisher N3ee27d795a80494591df680c42fd63a2
80 schema:url http://www.nature.com/ki/journal/v51/n1/full/ki199712a.html
81 sgo:license sg:explorer/license/
82 sgo:sdDataset articles
83 rdf:type schema:ScholarlyArticle
84 N0b0f8de2edb44ed0a58b150fae07e36d schema:volumeNumber 51
85 rdf:type schema:PublicationVolume
86 N1d4675e5f75b45f296b8a07c748a106b schema:name readcube_id
87 schema:value 6c83cea7dbb5b8b36c6191300608a74ccf39a6d55c479db9c7a45393e71e6926
88 rdf:type schema:PropertyValue
89 N2020d25be43d47158d0eb2840b6a7821 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Male
91 rdf:type schema:DefinedTerm
92 N241880f6c6c04cde971dd4b90a880610 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
93 schema:familyName Shuo
94 schema:givenName Li
95 rdf:type schema:Person
96 N2c31c280d7d249ba8fcb8e34e49ee427 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name CD4 Antigens
98 rdf:type schema:DefinedTerm
99 N2da5cbcf16e14f6889f744a196b992a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Interferon-gamma
101 rdf:type schema:DefinedTerm
102 N3ee27d795a80494591df680c42fd63a2 schema:name Springer Nature - SN SciGraph project
103 rdf:type schema:Organization
104 N572b8062743c48eeadda2f3aca755896 rdf:first sg:person.01131260677.45
105 rdf:rest rdf:nil
106 N58a77d86c6af40138e48ac6841a3d4ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Glomerulonephritis
108 rdf:type schema:DefinedTerm
109 N5c37b63f436541cea01a7bb69f8db39b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name T-Lymphocytes, Helper-Inducer
111 rdf:type schema:DefinedTerm
112 N66074bde60fb45a0b2ef891c45659fff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Mice, Inbred BALB C
114 rdf:type schema:DefinedTerm
115 N665c55ebf92d4fc2b41504b3b95db8fb schema:name pubmed_id
116 schema:value 8995722
117 rdf:type schema:PropertyValue
118 N6708309457a4483abb979c4a0b4a37d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Mice, Inbred C57BL
120 rdf:type schema:DefinedTerm
121 N6aca4395228e4329971931db1472bc1b schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N758329eb9c064e58971449ca39a0b617 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Antigens
125 rdf:type schema:DefinedTerm
126 N83f9a3f058bf480782270b347163c0b2 schema:name dimensions_id
127 schema:value pub.1022776985
128 rdf:type schema:PropertyValue
129 N86395013166341c783ecfd3e860febbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Globulins
131 rdf:type schema:DefinedTerm
132 N871a3dafa74141e1805e6c0445fd5864 rdf:first sg:person.0661674330.39
133 rdf:rest Nf7f1533ecdad4d0d88a520fa5e6b903d
134 N883c4c2fd90741d98db7ec5d7e5ab031 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Autoantibodies
136 rdf:type schema:DefinedTerm
137 N9e5f940581c04df3a50b30f556fcbf32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Immunoglobulins, Intravenous
139 rdf:type schema:DefinedTerm
140 Na070fc4d316d49e9b8fe9af56ed8a8cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Immunoglobulin G
142 rdf:type schema:DefinedTerm
143 Na5cc49a392554f69b6f8c2370c5f852b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 Na9faa24352d747528ec2321bc45dce8f schema:name nlm_unique_id
147 schema:value 0323470
148 rdf:type schema:PropertyValue
149 Nb2344f9b556244a5925ce53b8ea8edd0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Sheep
151 rdf:type schema:DefinedTerm
152 Nb2c259e272b4447d91944168a5dd6b57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Mice
154 rdf:type schema:DefinedTerm
155 Nb5262dd46464473d8bbcf5abb7f11e65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Proteinuria
157 rdf:type schema:DefinedTerm
158 Nbce151a366cb4648a325762bf6233002 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Complement System Proteins
160 rdf:type schema:DefinedTerm
161 Nbea8879e479c4cc0a4d1db2862fe59a5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
162 schema:name Creatinine
163 rdf:type schema:DefinedTerm
164 Ne1375b9e996d449ca9cec67adaa039b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Hypersensitivity, Delayed
166 rdf:type schema:DefinedTerm
167 Nec3e2da32181460886467ab7cfa41716 rdf:first sg:person.01233272432.56
168 rdf:rest N871a3dafa74141e1805e6c0445fd5864
169 Nf04ae741c21f4307a35e1ff53081e2b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Fibrin
171 rdf:type schema:DefinedTerm
172 Nf4ef5037174341ffa431a1738af3b3f3 schema:name doi
173 schema:value 10.1038/ki.1997.12
174 rdf:type schema:PropertyValue
175 Nf7f1533ecdad4d0d88a520fa5e6b903d rdf:first N241880f6c6c04cde971dd4b90a880610
176 rdf:rest N572b8062743c48eeadda2f3aca755896
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
181 schema:name Immunology
182 rdf:type schema:DefinedTerm
183 sg:journal.1015319 schema:issn 0085-2538
184 1523-1755
185 schema:name Kidney International
186 rdf:type schema:Periodical
187 sg:person.01131260677.45 schema:familyName Holdsworth
188 schema:givenName Stephen R
189 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
190 rdf:type schema:Person
191 sg:person.01233272432.56 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
192 schema:familyName Huang
193 schema:givenName Xiao-Ru
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56
195 rdf:type schema:Person
196 sg:person.0661674330.39 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
197 schema:familyName Tipping
198 schema:givenName Peter G
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39
200 rdf:type schema:Person
201 sg:pub.10.1007/bf00914967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003273042
202 https://doi.org/10.1007/bf00914967
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/ki.1979.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045525616
205 https://doi.org/10.1038/ki.1979.116
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/ki.1979.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561866
208 https://doi.org/10.1038/ki.1979.24
209 rdf:type schema:CreativeWork
210 sg:pub.10.1038/ki.1985.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002107889
211 https://doi.org/10.1038/ki.1985.43
212 rdf:type schema:CreativeWork
213 sg:pub.10.1038/ki.1986.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319567
214 https://doi.org/10.1038/ki.1986.239
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/ki.1987.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025518790
217 https://doi.org/10.1038/ki.1987.123
218 rdf:type schema:CreativeWork
219 sg:pub.10.1038/ki.1987.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023607228
220 https://doi.org/10.1038/ki.1987.288
221 rdf:type schema:CreativeWork
222 sg:pub.10.1038/ki.1988.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008590465
223 https://doi.org/10.1038/ki.1988.224
224 rdf:type schema:CreativeWork
225 sg:pub.10.1038/ki.1992.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029360728
226 https://doi.org/10.1038/ki.1992.221
227 rdf:type schema:CreativeWork
228 sg:pub.10.1038/ki.1994.245 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487393
229 https://doi.org/10.1038/ki.1994.245
230 rdf:type schema:CreativeWork
231 sg:pub.10.1038/ki.1994.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006373571
232 https://doi.org/10.1038/ki.1994.246
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1078897020 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1078937839 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1078986202 schema:CreativeWork
237 https://app.dimensions.ai/details/publication/pub.1079473991 schema:CreativeWork
238 https://app.dimensions.ai/details/publication/pub.1079482704 schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1079561258 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1079922532 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1082473596 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1082570130 schema:CreativeWork
243 https://doi.org/10.1002/eji.1830250103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007802347
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1002/eji.1830250508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030343590
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1002/eji.1830260228 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050112857
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0165-5728(94)90069-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039226332
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0167-5699(95)80068-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024359708
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0896-8411(91)90021-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041135273
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/s0065-2776(08)60652-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028361542
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/s0140-6736(88)90413-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045957451
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1084/jem.148.1.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047255809
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1084/jem.159.5.1560 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014111265
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1084/jem.161.2.378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043103548
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1084/jem.162.3.1105 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037768219
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1084/jem.169.1.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034245991
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1172/jci115055 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013498862
272 rdf:type schema:CreativeWork
273 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
274 schema:name Centre for Inflammatory Diseases, Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia
275 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...