Effects of sex hormones on mesangial cell proliferation and collagen synthesis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-10

AUTHORS

Gary Kwan, Joel Neugarten, Marcia Sherman, Qing Ding, Upinder Fotadar, Jun Lei, Sharon Silbiger

ABSTRACT

In a variety of renal diseases, males progress at a more rapid rate and have a more fulminant course than females. This gender difference may be related to the direct effects of sex hormones on the cells of the kidney. To evaluate this hypothesis, we studied the effects of estrogens and testosterone on mesangial cell proliferation and collagen synthesis. At 48 hours, estradiol at 10 nM and 100 nM had a modest proliferative effect on cultured mesangial cells, as measured by 3H thymidine incorporation into DNA and direct cell counting. This estradiol effect was fully reversed by Tamoxifen (1 microM). Estradiol had no effect on cellular proliferation at 1 microM concentrations, but suppressed proliferation at 10 microM doses. Testosterone had a modest but statistically insignificant effect on proliferation at 10 nM and 100 nM concentrations but no effect at 1 microM or 10 microM. Neither estradiol nor testosterone at 10 microM affected total cellular protein accumulation. Estradiol at 1 microM and 10 microM, markedly suppressed total collagen synthesis as measured by 3H proline incorporation, and specifically suppressed the synthesis of collagen types I and IV, as measured by immunoprecipitation and gel electrophoresis. Testosterone did not affect collagen synthesis. Estradiol also reduced the steady state message for the alpha 2 chain of type I collagen, while testosterone had no effect. Neither estradiol nor testosterone affected the steady state message for TGF beta or EGF. The direct effects of estradiol on mesangial cell collagen generation may help explain the slower development of glomerulosclerosis in women and therefore the "protective" effect of female gender on the progression of renal disease. More... »

PAGES

1173-1179

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1996.425

DOI

http://dx.doi.org/10.1038/ki.1996.425

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025569948

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8887275


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Division", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Collagen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermal Growth Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Estradiol", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoblotting", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA, Messenger", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Sprague-Dawley", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Testosterone", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transforming Growth Factor beta", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kwan", 
        "givenName": "Gary", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Neugarten", 
        "givenName": "Joel", 
        "id": "sg:person.01220213202.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220213202.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sherman", 
        "givenName": "Marcia", 
        "type": "Person"
      }, 
      {
        "familyName": "Ding", 
        "givenName": "Qing", 
        "id": "sg:person.0745212641.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745212641.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fotadar", 
        "givenName": "Upinder", 
        "id": "sg:person.012105563244.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105563244.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Jun", 
        "id": "sg:person.01201056550.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201056550.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Montefiore Medical Center", 
          "id": "https://www.grid.ac/institutes/grid.240283.f", 
          "name": [
            "Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Silbiger", 
        "givenName": "Sharon", 
        "id": "sg:person.01361323777.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361323777.32"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1159/000188022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001789801"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90395-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007138805"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/13.7.2485", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008134818"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-119-30182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011148110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-119-30182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011148110"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci114731", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012026354"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(87)90021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013321498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90024-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013929857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(12)80179-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014065467"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000182232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015234814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.87", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017358617", 
          "https://doi.org/10.1038/ki.1988.87"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(89)80096-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017859362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.78.6.3516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019155740"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.77.9.5201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024100683"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03008208109160249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024855295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320450203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025629456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.1320450203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025629456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000183130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027580018"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1993.120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028984409", 
          "https://doi.org/10.1038/ki.1993.120"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod36.2.277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029941430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/7.6.1541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033525211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.85.7.2307", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037761963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.56", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039304514", 
          "https://doi.org/10.1038/ki.1988.56"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.30.3.341", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040171096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9150(81)90004-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040491423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9150(81)90004-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040491423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00508365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040675847", 
          "https://doi.org/10.1007/bf00508365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00508365", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040675847", 
          "https://doi.org/10.1007/bf00508365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(88)90204-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042219309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(88)90204-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042219309"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1991.313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048517874", 
          "https://doi.org/10.1038/ki.1991.313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-4800(85)90066-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048973066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0272-6386(89)80068-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050295292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(80)90145-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050480907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-4731(80)90145-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050480907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0006-291x(88)90270-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051249259"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9150(85)90177-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051665577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9150(85)90177-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051665577"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.6.2107", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051845228"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/abio.1987.9999", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054484911"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00511a014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055178783"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3164526", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062595594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.6602382", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062639150"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-111-3-833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064256653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-124-3-1576", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064262232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-128-6-2723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064264281"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/endo-91-5-1227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064275274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-2-9-816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330335"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/mend-4-3-510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064330796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1992.262.4.f687", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1076998020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079148801", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1989.69.4.1347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079213024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079496714", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079504338", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079750884", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080058463", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000409751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081779796"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1995.269.3.h863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082419707"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082759780", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082762047", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082771020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpheart.1977.232.6.h617", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082957151"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1996-10", 
    "datePublishedReg": "1996-10-01", 
    "description": "In a variety of renal diseases, males progress at a more rapid rate and have a more fulminant course than females. This gender difference may be related to the direct effects of sex hormones on the cells of the kidney. To evaluate this hypothesis, we studied the effects of estrogens and testosterone on mesangial cell proliferation and collagen synthesis. At 48 hours, estradiol at 10 nM and 100 nM had a modest proliferative effect on cultured mesangial cells, as measured by 3H thymidine incorporation into DNA and direct cell counting. This estradiol effect was fully reversed by Tamoxifen (1 microM). Estradiol had no effect on cellular proliferation at 1 microM concentrations, but suppressed proliferation at 10 microM doses. Testosterone had a modest but statistically insignificant effect on proliferation at 10 nM and 100 nM concentrations but no effect at 1 microM or 10 microM. Neither estradiol nor testosterone at 10 microM affected total cellular protein accumulation. Estradiol at 1 microM and 10 microM, markedly suppressed total collagen synthesis as measured by 3H proline incorporation, and specifically suppressed the synthesis of collagen types I and IV, as measured by immunoprecipitation and gel electrophoresis. Testosterone did not affect collagen synthesis. Estradiol also reduced the steady state message for the alpha 2 chain of type I collagen, while testosterone had no effect. Neither estradiol nor testosterone affected the steady state message for TGF beta or EGF. The direct effects of estradiol on mesangial cell collagen generation may help explain the slower development of glomerulosclerosis in women and therefore the \"protective\" effect of female gender on the progression of renal disease.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1996.425", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "4", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "50"
      }
    ], 
    "name": "Effects of sex hormones on mesangial cell proliferation and collagen synthesis", 
    "pagination": "1173-1179", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "79d1057b87a0a5763820ae2f48f93e90c98de34ae913ccf7b9b4e5bfc5cfe2e1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "8887275"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1996.425"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025569948"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1996.425", 
      "https://app.dimensions.ai/details/publication/pub.1025569948"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:58", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v50/n4/abs/ki1996425a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1996.425'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1996.425'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1996.425'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1996.425'


 

This table displays all metadata directly associated to this object as RDF triples.

333 TRIPLES      21 PREDICATES      100 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1996.425 schema:about N1ff1a15594e345a8a9ad4d539a3ac8f9
2 N3db4af5b1457454cb193b398897df387
3 N47198f3cfe8e4b789d756028b11e8914
4 N792f394296dd459f86ec69323bf7dea1
5 N7eedc5a147ba4e0ab46fedc936626d02
6 Na35b4bd7ca74420390af8e0f8cd7c60c
7 Na52d9ccb9b59408686e9879d2a76b18f
8 Nab6b43cfbdea41e792764cd1b5ab50bb
9 Nae2050b42fd34a0683f56b468f3de4c8
10 Nb10d7682e2aa40b6a6be14222ca589b1
11 Nce93ad25f25b41149dde5c3298cc37b0
12 Nd2f3e944c81f406aa64c8786d3ecbb98
13 Ne45ae0aa448147f5a84c62d433190eed
14 Nece53fd312a64e2194108bff1227466e
15 Nf6e08173e3f1464eabdd74ec6d40b52a
16 Nfaf7489cb82b4e2b9e673df30a41b106
17 anzsrc-for:11
18 anzsrc-for:1103
19 schema:author Nd1c55559a9ab4e79af004fbdbe2ffb38
20 schema:citation sg:pub.10.1007/bf00508365
21 sg:pub.10.1038/ki.1988.56
22 sg:pub.10.1038/ki.1988.87
23 sg:pub.10.1038/ki.1991.313
24 sg:pub.10.1038/ki.1993.120
25 https://app.dimensions.ai/details/publication/pub.1079148801
26 https://app.dimensions.ai/details/publication/pub.1079496714
27 https://app.dimensions.ai/details/publication/pub.1079504338
28 https://app.dimensions.ai/details/publication/pub.1079750884
29 https://app.dimensions.ai/details/publication/pub.1080058463
30 https://app.dimensions.ai/details/publication/pub.1082759780
31 https://app.dimensions.ai/details/publication/pub.1082762047
32 https://app.dimensions.ai/details/publication/pub.1082771020
33 https://doi.org/10.1002/ajmg.1320450203
34 https://doi.org/10.1006/abio.1987.9999
35 https://doi.org/10.1016/0003-2697(87)90021-2
36 https://doi.org/10.1016/0006-291x(88)90270-7
37 https://doi.org/10.1016/0014-4800(85)90066-8
38 https://doi.org/10.1016/0021-9150(81)90004-6
39 https://doi.org/10.1016/0021-9150(85)90177-7
40 https://doi.org/10.1016/0022-4731(80)90145-4
41 https://doi.org/10.1016/0022-4731(88)90204-x
42 https://doi.org/10.1016/0092-8674(88)90024-4
43 https://doi.org/10.1016/0092-8674(90)90395-u
44 https://doi.org/10.1016/s0272-6386(12)80179-x
45 https://doi.org/10.1016/s0272-6386(89)80068-x
46 https://doi.org/10.1016/s0272-6386(89)80096-4
47 https://doi.org/10.1021/bi00511a014
48 https://doi.org/10.1073/pnas.77.9.5201
49 https://doi.org/10.1073/pnas.78.6.3516
50 https://doi.org/10.1073/pnas.85.7.2307
51 https://doi.org/10.1073/pnas.86.6.2107
52 https://doi.org/10.1093/nar/13.7.2485
53 https://doi.org/10.1093/nar/7.6.1541
54 https://doi.org/10.1095/biolreprod36.2.277
55 https://doi.org/10.1126/science.3164526
56 https://doi.org/10.1126/science.6602382
57 https://doi.org/10.1152/ajpheart.1977.232.6.h617
58 https://doi.org/10.1152/ajpheart.1995.269.3.h863
59 https://doi.org/10.1152/ajprenal.1992.262.4.f687
60 https://doi.org/10.1152/physrev.1989.69.4.1347
61 https://doi.org/10.1159/000182232
62 https://doi.org/10.1159/000183130
63 https://doi.org/10.1159/000188022
64 https://doi.org/10.1159/000409751
65 https://doi.org/10.1161/01.res.30.3.341
66 https://doi.org/10.1172/jci114731
67 https://doi.org/10.1210/endo-111-3-833
68 https://doi.org/10.1210/endo-124-3-1576
69 https://doi.org/10.1210/endo-128-6-2723
70 https://doi.org/10.1210/endo-91-5-1227
71 https://doi.org/10.1210/mend-2-9-816
72 https://doi.org/10.1210/mend-4-3-510
73 https://doi.org/10.3109/03008208109160249
74 https://doi.org/10.3181/00379727-119-30182
75 schema:datePublished 1996-10
76 schema:datePublishedReg 1996-10-01
77 schema:description In a variety of renal diseases, males progress at a more rapid rate and have a more fulminant course than females. This gender difference may be related to the direct effects of sex hormones on the cells of the kidney. To evaluate this hypothesis, we studied the effects of estrogens and testosterone on mesangial cell proliferation and collagen synthesis. At 48 hours, estradiol at 10 nM and 100 nM had a modest proliferative effect on cultured mesangial cells, as measured by 3H thymidine incorporation into DNA and direct cell counting. This estradiol effect was fully reversed by Tamoxifen (1 microM). Estradiol had no effect on cellular proliferation at 1 microM concentrations, but suppressed proliferation at 10 microM doses. Testosterone had a modest but statistically insignificant effect on proliferation at 10 nM and 100 nM concentrations but no effect at 1 microM or 10 microM. Neither estradiol nor testosterone at 10 microM affected total cellular protein accumulation. Estradiol at 1 microM and 10 microM, markedly suppressed total collagen synthesis as measured by 3H proline incorporation, and specifically suppressed the synthesis of collagen types I and IV, as measured by immunoprecipitation and gel electrophoresis. Testosterone did not affect collagen synthesis. Estradiol also reduced the steady state message for the alpha 2 chain of type I collagen, while testosterone had no effect. Neither estradiol nor testosterone affected the steady state message for TGF beta or EGF. The direct effects of estradiol on mesangial cell collagen generation may help explain the slower development of glomerulosclerosis in women and therefore the "protective" effect of female gender on the progression of renal disease.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree true
81 schema:isPartOf Nc8fc5c76f2ad4210a814a38ab203b6f6
82 Nfb1f315ac60d48abb4615030fba2c9a0
83 sg:journal.1015319
84 schema:name Effects of sex hormones on mesangial cell proliferation and collagen synthesis
85 schema:pagination 1173-1179
86 schema:productId N0a08786967124aa7b36b277099e23ec6
87 N575cd73d5cf54beabbf00027e7d9bdcb
88 Na8f230bbea2b4a569a057b1e1f8bc625
89 Ndad3438a05cf4171a7e600edaa14e410
90 Ne67df25dcdfc41729abc202ae5f395d3
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025569948
92 https://doi.org/10.1038/ki.1996.425
93 schema:sdDatePublished 2019-04-10T12:58
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher N730a14410ab4487586e0527c5645a4a0
96 schema:url http://www.nature.com/ki/journal/v50/n4/abs/ki1996425a.html
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N0a08786967124aa7b36b277099e23ec6 schema:name dimensions_id
101 schema:value pub.1025569948
102 rdf:type schema:PropertyValue
103 N15ba2dd5d2834303bba469b56a8a23ff rdf:first sg:person.01361323777.32
104 rdf:rest rdf:nil
105 N1ff1a15594e345a8a9ad4d539a3ac8f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Immunoblotting
107 rdf:type schema:DefinedTerm
108 N3db4af5b1457454cb193b398897df387 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cells, Cultured
110 rdf:type schema:DefinedTerm
111 N47198f3cfe8e4b789d756028b11e8914 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Rats, Sprague-Dawley
113 rdf:type schema:DefinedTerm
114 N482c3c63a13e403eabb935ad1993641f schema:affiliation https://www.grid.ac/institutes/grid.240283.f
115 schema:familyName Sherman
116 schema:givenName Marcia
117 rdf:type schema:Person
118 N575cd73d5cf54beabbf00027e7d9bdcb schema:name doi
119 schema:value 10.1038/ki.1996.425
120 rdf:type schema:PropertyValue
121 N65f946b21c5f465386d5df953e7de5d6 rdf:first N482c3c63a13e403eabb935ad1993641f
122 rdf:rest N7dc061db1bee40eb802b950405a5516c
123 N730a14410ab4487586e0527c5645a4a0 schema:name Springer Nature - SN SciGraph project
124 rdf:type schema:Organization
125 N792f394296dd459f86ec69323bf7dea1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Rats
127 rdf:type schema:DefinedTerm
128 N7dc061db1bee40eb802b950405a5516c rdf:first sg:person.0745212641.25
129 rdf:rest Nf41f32b108d149e998cf53b16c4bc0aa
130 N7eedc5a147ba4e0ab46fedc936626d02 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Epidermal Growth Factor
132 rdf:type schema:DefinedTerm
133 Na35b4bd7ca74420390af8e0f8cd7c60c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Testosterone
135 rdf:type schema:DefinedTerm
136 Na52d9ccb9b59408686e9879d2a76b18f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Kidney Glomerulus
138 rdf:type schema:DefinedTerm
139 Na8f230bbea2b4a569a057b1e1f8bc625 schema:name pubmed_id
140 schema:value 8887275
141 rdf:type schema:PropertyValue
142 Nab6b43cfbdea41e792764cd1b5ab50bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name RNA, Messenger
144 rdf:type schema:DefinedTerm
145 Nae2050b42fd34a0683f56b468f3de4c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Time Factors
147 rdf:type schema:DefinedTerm
148 Nb10d7682e2aa40b6a6be14222ca589b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Male
150 rdf:type schema:DefinedTerm
151 Nc8fc5c76f2ad4210a814a38ab203b6f6 schema:volumeNumber 50
152 rdf:type schema:PublicationVolume
153 Nce93ad25f25b41149dde5c3298cc37b0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
154 schema:name Collagen
155 rdf:type schema:DefinedTerm
156 Nd01e5bca9c0048f5984e3ca248e4ea7d rdf:first sg:person.01201056550.27
157 rdf:rest N15ba2dd5d2834303bba469b56a8a23ff
158 Nd1c55559a9ab4e79af004fbdbe2ffb38 rdf:first Nd81a49980e09434aaaae3f4b7a08e883
159 rdf:rest Neee8120e5348479abb6fd3760234deaa
160 Nd2f3e944c81f406aa64c8786d3ecbb98 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Dose-Response Relationship, Drug
162 rdf:type schema:DefinedTerm
163 Nd81a49980e09434aaaae3f4b7a08e883 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
164 schema:familyName Kwan
165 schema:givenName Gary
166 rdf:type schema:Person
167 Ndad3438a05cf4171a7e600edaa14e410 schema:name nlm_unique_id
168 schema:value 0323470
169 rdf:type schema:PropertyValue
170 Ne45ae0aa448147f5a84c62d433190eed schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Animals
172 rdf:type schema:DefinedTerm
173 Ne67df25dcdfc41729abc202ae5f395d3 schema:name readcube_id
174 schema:value 79d1057b87a0a5763820ae2f48f93e90c98de34ae913ccf7b9b4e5bfc5cfe2e1
175 rdf:type schema:PropertyValue
176 Nece53fd312a64e2194108bff1227466e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Estradiol
178 rdf:type schema:DefinedTerm
179 Neee8120e5348479abb6fd3760234deaa rdf:first sg:person.01220213202.20
180 rdf:rest N65f946b21c5f465386d5df953e7de5d6
181 Nf41f32b108d149e998cf53b16c4bc0aa rdf:first sg:person.012105563244.92
182 rdf:rest Nd01e5bca9c0048f5984e3ca248e4ea7d
183 Nf6e08173e3f1464eabdd74ec6d40b52a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Cell Division
185 rdf:type schema:DefinedTerm
186 Nfaf7489cb82b4e2b9e673df30a41b106 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Transforming Growth Factor beta
188 rdf:type schema:DefinedTerm
189 Nfb1f315ac60d48abb4615030fba2c9a0 schema:issueNumber 4
190 rdf:type schema:PublicationIssue
191 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
192 schema:name Medical and Health Sciences
193 rdf:type schema:DefinedTerm
194 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
195 schema:name Clinical Sciences
196 rdf:type schema:DefinedTerm
197 sg:journal.1015319 schema:issn 0085-2538
198 1523-1755
199 schema:name Kidney International
200 rdf:type schema:Periodical
201 sg:person.01201056550.27 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
202 schema:familyName Lei
203 schema:givenName Jun
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201056550.27
205 rdf:type schema:Person
206 sg:person.012105563244.92 schema:familyName Fotadar
207 schema:givenName Upinder
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012105563244.92
209 rdf:type schema:Person
210 sg:person.01220213202.20 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
211 schema:familyName Neugarten
212 schema:givenName Joel
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01220213202.20
214 rdf:type schema:Person
215 sg:person.01361323777.32 schema:affiliation https://www.grid.ac/institutes/grid.240283.f
216 schema:familyName Silbiger
217 schema:givenName Sharon
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01361323777.32
219 rdf:type schema:Person
220 sg:person.0745212641.25 schema:familyName Ding
221 schema:givenName Qing
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745212641.25
223 rdf:type schema:Person
224 sg:pub.10.1007/bf00508365 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040675847
225 https://doi.org/10.1007/bf00508365
226 rdf:type schema:CreativeWork
227 sg:pub.10.1038/ki.1988.56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039304514
228 https://doi.org/10.1038/ki.1988.56
229 rdf:type schema:CreativeWork
230 sg:pub.10.1038/ki.1988.87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017358617
231 https://doi.org/10.1038/ki.1988.87
232 rdf:type schema:CreativeWork
233 sg:pub.10.1038/ki.1991.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048517874
234 https://doi.org/10.1038/ki.1991.313
235 rdf:type schema:CreativeWork
236 sg:pub.10.1038/ki.1993.120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028984409
237 https://doi.org/10.1038/ki.1993.120
238 rdf:type schema:CreativeWork
239 https://app.dimensions.ai/details/publication/pub.1079148801 schema:CreativeWork
240 https://app.dimensions.ai/details/publication/pub.1079496714 schema:CreativeWork
241 https://app.dimensions.ai/details/publication/pub.1079504338 schema:CreativeWork
242 https://app.dimensions.ai/details/publication/pub.1079750884 schema:CreativeWork
243 https://app.dimensions.ai/details/publication/pub.1080058463 schema:CreativeWork
244 https://app.dimensions.ai/details/publication/pub.1082759780 schema:CreativeWork
245 https://app.dimensions.ai/details/publication/pub.1082762047 schema:CreativeWork
246 https://app.dimensions.ai/details/publication/pub.1082771020 schema:CreativeWork
247 https://doi.org/10.1002/ajmg.1320450203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025629456
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1006/abio.1987.9999 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054484911
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/0003-2697(87)90021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013321498
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/0006-291x(88)90270-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051249259
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/0014-4800(85)90066-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048973066
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/0021-9150(81)90004-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040491423
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/0021-9150(85)90177-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051665577
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/0022-4731(80)90145-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050480907
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/0022-4731(88)90204-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042219309
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/0092-8674(88)90024-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013929857
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/0092-8674(90)90395-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1007138805
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/s0272-6386(12)80179-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014065467
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/s0272-6386(89)80068-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050295292
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0272-6386(89)80096-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017859362
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1021/bi00511a014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055178783
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1073/pnas.77.9.5201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024100683
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1073/pnas.78.6.3516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019155740
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1073/pnas.85.7.2307 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037761963
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1073/pnas.86.6.2107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051845228
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/nar/13.7.2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008134818
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1093/nar/7.6.1541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033525211
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1095/biolreprod36.2.277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029941430
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1126/science.3164526 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062595594
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1126/science.6602382 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062639150
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1152/ajpheart.1977.232.6.h617 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082957151
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1152/ajpheart.1995.269.3.h863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082419707
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1152/ajprenal.1992.262.4.f687 schema:sameAs https://app.dimensions.ai/details/publication/pub.1076998020
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1152/physrev.1989.69.4.1347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079213024
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1159/000182232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015234814
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1159/000183130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027580018
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1159/000188022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001789801
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1159/000409751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081779796
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1161/01.res.30.3.341 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040171096
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1172/jci114731 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012026354
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1210/endo-111-3-833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064256653
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1210/endo-124-3-1576 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064262232
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1210/endo-128-6-2723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064264281
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1210/endo-91-5-1227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064275274
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1210/mend-2-9-816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330335
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1210/mend-4-3-510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064330796
326 rdf:type schema:CreativeWork
327 https://doi.org/10.3109/03008208109160249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024855295
328 rdf:type schema:CreativeWork
329 https://doi.org/10.3181/00379727-119-30182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011148110
330 rdf:type schema:CreativeWork
331 https://www.grid.ac/institutes/grid.240283.f schema:alternateName Montefiore Medical Center
332 schema:name Department of Medicine, Division of Nephrology, Montefiore Medical Center and the Albert Einstein College of Medicine, Bronx, New York, USA
333 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...