Acute passive anti-glomerular basement membrane nephritis in P-selectin-deficient mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-05

AUTHORS

T N Mayadas, D L Mendrick, H R Brady, T Tang, A Papayianni, K J Assmann, D D Wagner, R O Hynes, R S Cotran

ABSTRACT

P-selectin present on surfaces of activated endothelium and platelets mediates neutrophil-endothelial and neutrophilplatelet interactions. The role of P-selectin in vivo was examined in a model of acute passive anti-GBM nephritis in P-selectin-deficient and wild-type mice which was induced by intravenous injection of anti-GBM serum. There were two major differences between P-selectin-deficient and wild-type mice. Firstly, mutant mice had approximately two fold more glomerular PMNs and albuminuria than wild-type animals at the peak of neutrophil influx and proteinuria. Secondly, Lipoxin A4 (LXA4), an eicosanoid which inhibits leukocyte-endothelial adhesion in vitro, and is generated primarily by transcellular biosynthetic routes during P-selectin-mediated platelet-PMN interaction [1], was approximately 60% of wild type levels in nephritic kidneys of P-selectin-deficient mice. Injection of wild-type platelets into P-selectin-null mice restored LXA4 to wild-type levels. The corresponding PMN influx approximated PMN levels in wild-type mice receiving platelets but urine albuminuria remained higher. Although these two P-selectin-dependent events cannot be directly linked, our results point to the importance of considering both platelet and endothelial P-selectin in determining the cellular events in inflammation. More... »

PAGES

1342-1349

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1996.190

DOI

http://dx.doi.org/10.1038/ki.1996.190

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023315851

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8731099


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