Anti-Fas antibodies induce cytolysis and apoptosis in cultured human mesangial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1996-04

AUTHORS

S González-Cuadrado, M J López-Armada, C Gómez-Guerrero, D Subirá, A Garcia-Sahuquillo, A Ortiz-Gonzalez, E G Neilson, J Egido, A Ortiz

ABSTRACT

Death of renal cells often occurs during the acute and resolution phases of some forms of glomerulonephritis. The apoptotic Fas protein belongs to a recently described family of cytokine receptors with similarities to tumor necrosis factor (TNF) receptors, and may contribute to the necrobiology of renal cells. Fas transduces a signal for apoptosis in sensitive cells after binding by specific antibodies or following contact with natural Fas ligand. We have studied Fas in cultured human mesangial cells. Cytoflurography demonstrated Fas expression on the surface of human mesangial cells that was increased by stimulation with interferon gamma (IFN gamma). Agonistic anti-human Fas antibodies were cytotoxic to these cells. Cytotoxicity was time- and dose-dependent, and was modulated by pre-stimulation of the mesangial cells with IFN gamma and/or by co-treatment with actinomycin-D. Mesangial cell death following exposure to anti-Fas antibodies has features consistent with apoptosis, such as internucleosomal DNA fragmentation, nuclear shrinkage and condensation, and decreased DNA content. These data suggest that Fas and its ligand could play a mechanistic role in human glomerular cell injury. More... »

PAGES

1064-1070

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1996.155

DOI

http://dx.doi.org/10.1038/ki.1996.155

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/8691726


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