Ontology type: schema:ScholarlyArticle Open Access: True
1995-11
AUTHORSL M Canessa, M M Piccio, P Vachvanichsanong, A Sidhu, C C Porter, J E Robillard, R A Felder, P A Jose
ABSTRACTAlthough several alpha-adrenergic receptor genes are expressed in the rat kidney, their expression in the renal vasculature has not been studied. Since pharmacological studies have suggested that an alpha 1B-adrenergic receptor may mediate renal vasoconstriction, we studied the expression of alpha 1B-adrenergic receptors in renal microvessels, from 10- to 14-week-old male spontaneously hypertensive rats (SHR) and their normotensive control, the Wistar-Kyoto rat (WKY). In these microvessels, isolated by perfusion with iron, alpha 1B-adrenergic receptor mRNA levels (by ribonuclease protection assay) were similar in SHR and WKY rats. Photo-affinity labeling with [125I]-arylazidoprazosin demonstrated the presence of alpha 1B-adrenergic receptor protein. Maximum receptor density (determined by 3H-prazosin binding: Bmax 59.8 +/- 4.1 and 58.7 +/- 4.3; Kd 0.48 +/- 0.05 nM and 0.31 +/- 0.06 nM in SHR and WKY, respectively) and chloroethylclonidine (CEC)-sensitive binding sites (determined by [125I]-(2-beta(4-hydroxyphenyl)-ethylaminomethyl)-tetralone binding) (125I-HEAT) were similar in SHR and WKY rats. There are two novel findings in these studies: (1) the alpha 1B-adrenergic receptor gene is expressed in renal microvessels of WKY and SHR; (2) alpha 1B-adrenergic receptor gene expression in renal microvessels is not altered in adult SHR. The failure to down-regulate expression of the alpha 1B-adrenergic receptor at the mRNA and protein level in the SHR could result in persistence of alpha 1B-adrenergic receptor effects and contribute to the increased vascular resistance in hypertension. More... »
PAGES1412-1419
http://scigraph.springernature.com/pub.10.1038/ki.1995.430
DOIhttp://dx.doi.org/10.1038/ki.1995.430
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1017241334
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/8544397
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1115",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Pharmacology and Pharmaceutical Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Affinity Labels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alkylating Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Animals",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Azides",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Binding Sites",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blood Vessels",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Clonidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Microcirculation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prazosin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "RNA, Messenger",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Radioligand Assay",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred SHR",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Rats, Inbred WKY",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Adrenergic, alpha",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Renal Circulation",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Dayton Children's Hospital",
"id": "https://www.grid.ac/institutes/grid.414197.e",
"name": [
"Department of Pediatrics, Georgetown University Children's Medical Center, Washington, D.C., USA."
],
"type": "Organization"
},
"familyName": "Canessa",
"givenName": "L M",
"id": "sg:person.0604170346.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604170346.76"
],
"type": "Person"
},
{
"familyName": "Piccio",
"givenName": "M M",
"id": "sg:person.01025236244.44",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01025236244.44"
],
"type": "Person"
},
{
"familyName": "Vachvanichsanong",
"givenName": "P",
"id": "sg:person.0652147362.26",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652147362.26"
],
"type": "Person"
},
{
"familyName": "Sidhu",
"givenName": "A",
"id": "sg:person.01134137170.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01134137170.45"
],
"type": "Person"
},
{
"familyName": "Porter",
"givenName": "C C",
"id": "sg:person.01104674770.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01104674770.87"
],
"type": "Person"
},
{
"familyName": "Robillard",
"givenName": "J E",
"id": "sg:person.0600364522.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600364522.14"
],
"type": "Person"
},
{
"familyName": "Felder",
"givenName": "R A",
"id": "sg:person.01053633257.41",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053633257.41"
],
"type": "Person"
},
{
"familyName": "Jose",
"givenName": "P A",
"id": "sg:person.0752471415.51",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752471415.51"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1097/00005792-197803000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002626120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005792-197803000-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002626120"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0470435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011673401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0470435",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011673401"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1536/ihj.19.886",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012311489"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.4.6.908",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012645895"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3109/13813457409072338",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014254559"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci117656",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018562960"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.85.19.7159",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019951620"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci114680",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020564020"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.13.6.851",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029819617"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0026-2862(78)90060-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035211366"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.19.4.365",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037239897"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1476-5381.1992.tb12760.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040527931"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.22.2.169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041336337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.12.1.80",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043212119"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ki.1989.178",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043507865",
"https://doi.org/10.1038/ki.1989.178"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1161/01.hyp.9.1.41",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043747935"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ki.1990.164",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044041051",
"https://doi.org/10.1038/ki.1990.164"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005344-199402000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049464336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00005344-199402000-00009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049464336"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1006/bbrc.1994.1575",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049689503"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/nar/18.4.1053",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051059552"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-2999(90)90443-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051699192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0014-2999(90)90443-a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051699192"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/bi00591a005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1055181913"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0740063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056724432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/cs0740063",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1056724432"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/00004872-199212000-00015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1060192819"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.6.3.1346768",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1075760936"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076750128",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077217136",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077223575",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077315043",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1077949316",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajprenal.1990.258.3.f606",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078361082"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078397351",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1096/fasebj.3.2.2536629",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078997728"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079412244",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079417307",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079506533",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1080709053",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081655359",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajpheart.1980.238.3.h287",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082314988"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082669001",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082690623",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1152/ajprenal.1993.264.2.f280",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1082810450"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083042373",
"type": "CreativeWork"
}
],
"datePublished": "1995-11",
"datePublishedReg": "1995-11-01",
"description": "Although several alpha-adrenergic receptor genes are expressed in the rat kidney, their expression in the renal vasculature has not been studied. Since pharmacological studies have suggested that an alpha 1B-adrenergic receptor may mediate renal vasoconstriction, we studied the expression of alpha 1B-adrenergic receptors in renal microvessels, from 10- to 14-week-old male spontaneously hypertensive rats (SHR) and their normotensive control, the Wistar-Kyoto rat (WKY). In these microvessels, isolated by perfusion with iron, alpha 1B-adrenergic receptor mRNA levels (by ribonuclease protection assay) were similar in SHR and WKY rats. Photo-affinity labeling with [125I]-arylazidoprazosin demonstrated the presence of alpha 1B-adrenergic receptor protein. Maximum receptor density (determined by 3H-prazosin binding: Bmax 59.8 +/- 4.1 and 58.7 +/- 4.3; Kd 0.48 +/- 0.05 nM and 0.31 +/- 0.06 nM in SHR and WKY, respectively) and chloroethylclonidine (CEC)-sensitive binding sites (determined by [125I]-(2-beta(4-hydroxyphenyl)-ethylaminomethyl)-tetralone binding) (125I-HEAT) were similar in SHR and WKY rats. There are two novel findings in these studies: (1) the alpha 1B-adrenergic receptor gene is expressed in renal microvessels of WKY and SHR; (2) alpha 1B-adrenergic receptor gene expression in renal microvessels is not altered in adult SHR. The failure to down-regulate expression of the alpha 1B-adrenergic receptor at the mRNA and protein level in the SHR could result in persistence of alpha 1B-adrenergic receptor effects and contribute to the increased vascular resistance in hypertension.",
"genre": "research_article",
"id": "sg:pub.10.1038/ki.1995.430",
"inLanguage": [
"en"
],
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.2635622",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2494509",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2493758",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.2530015",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1015319",
"issn": [
"0085-2538",
"1523-1755"
],
"name": "Kidney International",
"type": "Periodical"
},
{
"issueNumber": "5",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "48"
}
],
"name": "\u03b11B-adrenergic receptors in rat renal microvessels",
"pagination": "1412-1419",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"522538a43a8b5daf11d0b3c75409650f06c00415b716f08f9a537de8feb4c05b"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"8544397"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"0323470"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/ki.1995.430"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1017241334"
]
}
],
"sameAs": [
"https://doi.org/10.1038/ki.1995.430",
"https://app.dimensions.ai/details/publication/pub.1017241334"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T16:53",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000584.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/ki/journal/v48/n5/abs/ki1995430a.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1995.430'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1995.430'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1995.430'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1995.430'
This table displays all metadata directly associated to this object as RDF triples.
304 TRIPLES
21 PREDICATES
89 URIs
38 LITERALS
26 BLANK NODES