Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1994-07

AUTHORS

X R Huang, S R Holdsworth, P G Tipping

ABSTRACT

The role of CD4-positive T cells in glomerular crescent formation was examined in WKY rats. Glomerulonephritis (GN) was induced by a subnephritogenic intravenous dose of sheep anti-rat GBM antibody in rats previously sensitized to sheep globulin. This resulted in a severe proliferative and crescentic GN, with marked proteinuria [143 +/- 40 mg/24 hr (mean +/- SD), normal 1.6 +/- 0.7 mg/24 hr] and crescent formation involving 59 +/- 8% of glomeruli at day 10 (normal 0%). Humoral immunity to sheep globulin was evident systemically by high titers of circulating anti-sheep globulin and locally by linear deposition of rat immunoglobulin in glomeruli and cell mediated immunity by cutaneous delayed-type hypersensitivity (DTH) to intradermal injection of sheep globulin. Glomerular accumulation of CD5 positive T cells [2.45 +/- 0.21 cells per glomerular cross section (c/gcs), normal 0.18 +/- 0.10 c/gcs], CD4 positive T cells, (1.87 +/- 0.46 c/gcs, normal 0.14 +/- 0.08 c/gcs), and macrophages (22.7 +/- 5.9 c/gcs, normal 0.05 +/- 0.05 c/gcs), together with the appearance of multinucleated giant cells (0.42 +/- 0.15 c/gcs, normal 0 c/gcs) suggested a DTH-like reaction in glomeruli. Sensitized rats given anti-GBM globulin were treated with monoclonal anti-CD5 or anti-CD4 antibodies in a protocol which prevented cutaneous DTH to sheep globulin without altering the humoral immune response. Both treatments significantly reduced glomerular accumulation of CD5 and CD4 positive T cells at day 10. Crescent formation was significantly reduced (CD5 treated, 13 +/- 4% of glomeruli affected; P < 0.001; CD4 treated 13 +/- 3% of glomeruli affected, P < 0.001) compared to rats treated with an isotype-matched irrelevant monoclonal antibody. Glomerular macrophage accumulation, multinucleated giant cell formation and proteinuria were also significantly reduced by both treatments. These studies demonstrate a functional role for CD4 positive T cells as effector cells within glomeruli, separate from their role in humoral immunity, in the development of crescentic GN. The local participation of CD4 positive T cells, macrophages and multinucleated giant cells in crescent formation, and the attenuation of these features by functional T helper cell depletion suggest that local DTH-like mechanisms may contribute to glomerular crescent formation. More... »

PAGES

69-78

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1994.245

DOI

http://dx.doi.org/10.1038/ki.1994.245

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1053487393

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/7523756


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Basement Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD4-Positive T-Lymphocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "CD5 Antigens", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Complement C3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerulonephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypersensitivity, Delayed", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney Glomerulus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lymphocyte Depletion", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Macrophages", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred WKY", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash Medical Centre", 
          "id": "https://www.grid.ac/institutes/grid.416060.5", 
          "name": [
            "Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "X R", 
        "id": "sg:person.01233272432.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Holdsworth", 
        "givenName": "S R", 
        "id": "sg:person.01131260677.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tipping", 
        "givenName": "P G", 
        "id": "sg:person.0661674330.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ki.1985.43", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002107889", 
          "https://doi.org/10.1038/ki.1985.43"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00914967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003273042", 
          "https://doi.org/10.1007/bf00914967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.1.73", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004687466"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1979.24", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006561866", 
          "https://doi.org/10.1038/ki.1979.24"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.224", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008590465", 
          "https://doi.org/10.1038/ki.1988.224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(88)90075-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009373991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-510x(88)90075-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009373991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-3083.1989.tb01218.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017632770"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.4.1373", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018233482"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(76)90480-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018838853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(76)90480-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018838853"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4613-2463-8_50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019590164", 
          "https://doi.org/10.1007/978-1-4613-2463-8_50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1992.tb01421.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021591427"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023607228", 
          "https://doi.org/10.1038/ki.1987.288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.162.1.117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025492434"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025518790", 
          "https://doi.org/10.1038/ki.1987.123"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0003-2697(76)90527-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025529346"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1992.221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029360728", 
          "https://doi.org/10.1038/ki.1992.221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830220110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034820409"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.165.2.368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037013974"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.148.1.246", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047255809"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/eji.1830140311", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051635975"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052319567", 
          "https://doi.org/10.1038/ki.1986.239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075765047", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078897020", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079891557", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080012491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081622178", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081636649", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081686328", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082102536", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1994-07", 
    "datePublishedReg": "1994-07-01", 
    "description": "The role of CD4-positive T cells in glomerular crescent formation was examined in WKY rats. Glomerulonephritis (GN) was induced by a subnephritogenic intravenous dose of sheep anti-rat GBM antibody in rats previously sensitized to sheep globulin. This resulted in a severe proliferative and crescentic GN, with marked proteinuria [143 +/- 40 mg/24 hr (mean +/- SD), normal 1.6 +/- 0.7 mg/24 hr] and crescent formation involving 59 +/- 8% of glomeruli at day 10 (normal 0%). Humoral immunity to sheep globulin was evident systemically by high titers of circulating anti-sheep globulin and locally by linear deposition of rat immunoglobulin in glomeruli and cell mediated immunity by cutaneous delayed-type hypersensitivity (DTH) to intradermal injection of sheep globulin. Glomerular accumulation of CD5 positive T cells [2.45 +/- 0.21 cells per glomerular cross section (c/gcs), normal 0.18 +/- 0.10 c/gcs], CD4 positive T cells, (1.87 +/- 0.46 c/gcs, normal 0.14 +/- 0.08 c/gcs), and macrophages (22.7 +/- 5.9 c/gcs, normal 0.05 +/- 0.05 c/gcs), together with the appearance of multinucleated giant cells (0.42 +/- 0.15 c/gcs, normal 0 c/gcs) suggested a DTH-like reaction in glomeruli. Sensitized rats given anti-GBM globulin were treated with monoclonal anti-CD5 or anti-CD4 antibodies in a protocol which prevented cutaneous DTH to sheep globulin without altering the humoral immune response. Both treatments significantly reduced glomerular accumulation of CD5 and CD4 positive T cells at day 10. Crescent formation was significantly reduced (CD5 treated, 13 +/- 4% of glomeruli affected; P < 0.001; CD4 treated 13 +/- 3% of glomeruli affected, P < 0.001) compared to rats treated with an isotype-matched irrelevant monoclonal antibody. Glomerular macrophage accumulation, multinucleated giant cell formation and proteinuria were also significantly reduced by both treatments. These studies demonstrate a functional role for CD4 positive T cells as effector cells within glomeruli, separate from their role in humoral immunity, in the development of crescentic GN. The local participation of CD4 positive T cells, macrophages and multinucleated giant cells in crescent formation, and the attenuation of these features by functional T helper cell depletion suggest that local DTH-like mechanisms may contribute to glomerular crescent formation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1994.245", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "46"
      }
    ], 
    "name": "Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation", 
    "pagination": "69-78", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "fec4392eccf477ab19a9cd22839fad8d526ab68fea319b255e28343e6f254892"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "7523756"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1994.245"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1053487393"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1994.245", 
      "https://app.dimensions.ai/details/publication/pub.1053487393"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v46/n1/abs/ki1994245a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1994.245'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1994.245'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1994.245'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1994.245'


 

This table displays all metadata directly associated to this object as RDF triples.

225 TRIPLES      21 PREDICATES      72 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1994.245 schema:about N005218861c544919ba84c9802c6c3f2d
2 N07fa77e87c6e4ef6ba8dff6944b9cc0a
3 N2c0517b7885743d2bd57c5158d029dd7
4 N431214e673ac463bbd0ce9375e56f4dc
5 N5d26618d618c4ea8a380044e20c2618d
6 N8106345d7c1647108d8c3911f914855a
7 N8645ff193f974ba78468bd12b7a67edf
8 N97d5688832a54170aa9f5cb089e1e8ce
9 N9cc0b5a81cc04277893f95c38409906c
10 Na7786c69c95642e88edcf8a6057c6543
11 Nc817fc4ed94d4c74b88e0a51caae0472
12 Nc9955575fa6e41298e8c8f2870770214
13 Nca436327b7ac4793a7c86ef9bd4d7416
14 Ndf3b8fb016c840ef8fddefb6cbe2e864
15 anzsrc-for:11
16 anzsrc-for:1107
17 schema:author N1b4256bcea3b48908edd56fb7a6c71f4
18 schema:citation sg:pub.10.1007/978-1-4613-2463-8_50
19 sg:pub.10.1007/bf00914967
20 sg:pub.10.1038/ki.1979.24
21 sg:pub.10.1038/ki.1985.43
22 sg:pub.10.1038/ki.1986.239
23 sg:pub.10.1038/ki.1987.123
24 sg:pub.10.1038/ki.1987.288
25 sg:pub.10.1038/ki.1988.224
26 sg:pub.10.1038/ki.1992.221
27 https://app.dimensions.ai/details/publication/pub.1075765047
28 https://app.dimensions.ai/details/publication/pub.1078897020
29 https://app.dimensions.ai/details/publication/pub.1079891557
30 https://app.dimensions.ai/details/publication/pub.1080012491
31 https://app.dimensions.ai/details/publication/pub.1081622178
32 https://app.dimensions.ai/details/publication/pub.1081636649
33 https://app.dimensions.ai/details/publication/pub.1081686328
34 https://app.dimensions.ai/details/publication/pub.1082102536
35 https://doi.org/10.1002/eji.1830140311
36 https://doi.org/10.1002/eji.1830220110
37 https://doi.org/10.1016/0003-2697(76)90527-3
38 https://doi.org/10.1016/0022-510x(88)90075-5
39 https://doi.org/10.1016/s0140-6736(76)90480-3
40 https://doi.org/10.1084/jem.148.1.246
41 https://doi.org/10.1084/jem.162.1.117
42 https://doi.org/10.1084/jem.165.2.368
43 https://doi.org/10.1084/jem.169.1.73
44 https://doi.org/10.1084/jem.169.4.1373
45 https://doi.org/10.1111/j.1365-3083.1989.tb01218.x
46 https://doi.org/10.1111/j.1600-065x.1992.tb01421.x
47 schema:datePublished 1994-07
48 schema:datePublishedReg 1994-07-01
49 schema:description The role of CD4-positive T cells in glomerular crescent formation was examined in WKY rats. Glomerulonephritis (GN) was induced by a subnephritogenic intravenous dose of sheep anti-rat GBM antibody in rats previously sensitized to sheep globulin. This resulted in a severe proliferative and crescentic GN, with marked proteinuria [143 +/- 40 mg/24 hr (mean +/- SD), normal 1.6 +/- 0.7 mg/24 hr] and crescent formation involving 59 +/- 8% of glomeruli at day 10 (normal 0%). Humoral immunity to sheep globulin was evident systemically by high titers of circulating anti-sheep globulin and locally by linear deposition of rat immunoglobulin in glomeruli and cell mediated immunity by cutaneous delayed-type hypersensitivity (DTH) to intradermal injection of sheep globulin. Glomerular accumulation of CD5 positive T cells [2.45 +/- 0.21 cells per glomerular cross section (c/gcs), normal 0.18 +/- 0.10 c/gcs], CD4 positive T cells, (1.87 +/- 0.46 c/gcs, normal 0.14 +/- 0.08 c/gcs), and macrophages (22.7 +/- 5.9 c/gcs, normal 0.05 +/- 0.05 c/gcs), together with the appearance of multinucleated giant cells (0.42 +/- 0.15 c/gcs, normal 0 c/gcs) suggested a DTH-like reaction in glomeruli. Sensitized rats given anti-GBM globulin were treated with monoclonal anti-CD5 or anti-CD4 antibodies in a protocol which prevented cutaneous DTH to sheep globulin without altering the humoral immune response. Both treatments significantly reduced glomerular accumulation of CD5 and CD4 positive T cells at day 10. Crescent formation was significantly reduced (CD5 treated, 13 +/- 4% of glomeruli affected; P < 0.001; CD4 treated 13 +/- 3% of glomeruli affected, P < 0.001) compared to rats treated with an isotype-matched irrelevant monoclonal antibody. Glomerular macrophage accumulation, multinucleated giant cell formation and proteinuria were also significantly reduced by both treatments. These studies demonstrate a functional role for CD4 positive T cells as effector cells within glomeruli, separate from their role in humoral immunity, in the development of crescentic GN. The local participation of CD4 positive T cells, macrophages and multinucleated giant cells in crescent formation, and the attenuation of these features by functional T helper cell depletion suggest that local DTH-like mechanisms may contribute to glomerular crescent formation.
50 schema:genre research_article
51 schema:inLanguage en
52 schema:isAccessibleForFree true
53 schema:isPartOf N0b13d99e369049e8963246d95719189c
54 Nedf6cfbe30dd4396885e7f9eb0c11eaa
55 sg:journal.1015319
56 schema:name Evidence for delayed-type hypersensitivity mechanisms in glomerular crescent formation
57 schema:pagination 69-78
58 schema:productId N2199afa35d684eb6972fc8763c925eeb
59 N371466835dbd4d74a995d1a672a3921b
60 N4c2d612b6a1b4787a7553290aef6b024
61 N64aed57dfdd04abcbf2d9044bb18a325
62 N99a53e10c38041e0afdc987fe3c19d2d
63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053487393
64 https://doi.org/10.1038/ki.1994.245
65 schema:sdDatePublished 2019-04-11T00:55
66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
67 schema:sdPublisher N9c023177bf4a40d08107ec3e8e7591d8
68 schema:url http://www.nature.com/ki/journal/v46/n1/abs/ki1994245a.html
69 sgo:license sg:explorer/license/
70 sgo:sdDataset articles
71 rdf:type schema:ScholarlyArticle
72 N005218861c544919ba84c9802c6c3f2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Glomerulonephritis
74 rdf:type schema:DefinedTerm
75 N0373c2bda9584f83b0102eb3c2a1b189 rdf:first sg:person.01131260677.45
76 rdf:rest Nbfed0b7cda8743dfa41d50b297170aca
77 N07fa77e87c6e4ef6ba8dff6944b9cc0a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Rats, Inbred WKY
79 rdf:type schema:DefinedTerm
80 N0b13d99e369049e8963246d95719189c schema:volumeNumber 46
81 rdf:type schema:PublicationVolume
82 N1b4256bcea3b48908edd56fb7a6c71f4 rdf:first sg:person.01233272432.56
83 rdf:rest N0373c2bda9584f83b0102eb3c2a1b189
84 N2199afa35d684eb6972fc8763c925eeb schema:name dimensions_id
85 schema:value pub.1053487393
86 rdf:type schema:PropertyValue
87 N2c0517b7885743d2bd57c5158d029dd7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name CD4-Positive T-Lymphocytes
89 rdf:type schema:DefinedTerm
90 N371466835dbd4d74a995d1a672a3921b schema:name pubmed_id
91 schema:value 7523756
92 rdf:type schema:PropertyValue
93 N431214e673ac463bbd0ce9375e56f4dc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
94 schema:name Macrophages
95 rdf:type schema:DefinedTerm
96 N4c2d612b6a1b4787a7553290aef6b024 schema:name nlm_unique_id
97 schema:value 0323470
98 rdf:type schema:PropertyValue
99 N5d26618d618c4ea8a380044e20c2618d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Antigens, CD
101 rdf:type schema:DefinedTerm
102 N64aed57dfdd04abcbf2d9044bb18a325 schema:name doi
103 schema:value 10.1038/ki.1994.245
104 rdf:type schema:PropertyValue
105 N8106345d7c1647108d8c3911f914855a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Complement C3
107 rdf:type schema:DefinedTerm
108 N8645ff193f974ba78468bd12b7a67edf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name CD5 Antigens
110 rdf:type schema:DefinedTerm
111 N97d5688832a54170aa9f5cb089e1e8ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Lymphocyte Depletion
113 rdf:type schema:DefinedTerm
114 N99a53e10c38041e0afdc987fe3c19d2d schema:name readcube_id
115 schema:value fec4392eccf477ab19a9cd22839fad8d526ab68fea319b255e28343e6f254892
116 rdf:type schema:PropertyValue
117 N9c023177bf4a40d08107ec3e8e7591d8 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 N9cc0b5a81cc04277893f95c38409906c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Basement Membrane
121 rdf:type schema:DefinedTerm
122 Na7786c69c95642e88edcf8a6057c6543 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Kidney Glomerulus
124 rdf:type schema:DefinedTerm
125 Nbfed0b7cda8743dfa41d50b297170aca rdf:first sg:person.0661674330.39
126 rdf:rest rdf:nil
127 Nc817fc4ed94d4c74b88e0a51caae0472 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Rats
129 rdf:type schema:DefinedTerm
130 Nc9955575fa6e41298e8c8f2870770214 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Male
132 rdf:type schema:DefinedTerm
133 Nca436327b7ac4793a7c86ef9bd4d7416 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Animals
135 rdf:type schema:DefinedTerm
136 Ndf3b8fb016c840ef8fddefb6cbe2e864 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
137 schema:name Hypersensitivity, Delayed
138 rdf:type schema:DefinedTerm
139 Nedf6cfbe30dd4396885e7f9eb0c11eaa schema:issueNumber 1
140 rdf:type schema:PublicationIssue
141 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
142 schema:name Medical and Health Sciences
143 rdf:type schema:DefinedTerm
144 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
145 schema:name Immunology
146 rdf:type schema:DefinedTerm
147 sg:journal.1015319 schema:issn 0085-2538
148 1523-1755
149 schema:name Kidney International
150 rdf:type schema:Periodical
151 sg:person.01131260677.45 schema:familyName Holdsworth
152 schema:givenName S R
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01131260677.45
154 rdf:type schema:Person
155 sg:person.01233272432.56 schema:affiliation https://www.grid.ac/institutes/grid.416060.5
156 schema:familyName Huang
157 schema:givenName X R
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01233272432.56
159 rdf:type schema:Person
160 sg:person.0661674330.39 schema:familyName Tipping
161 schema:givenName P G
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661674330.39
163 rdf:type schema:Person
164 sg:pub.10.1007/978-1-4613-2463-8_50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019590164
165 https://doi.org/10.1007/978-1-4613-2463-8_50
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/bf00914967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003273042
168 https://doi.org/10.1007/bf00914967
169 rdf:type schema:CreativeWork
170 sg:pub.10.1038/ki.1979.24 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006561866
171 https://doi.org/10.1038/ki.1979.24
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/ki.1985.43 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002107889
174 https://doi.org/10.1038/ki.1985.43
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/ki.1986.239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052319567
177 https://doi.org/10.1038/ki.1986.239
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/ki.1987.123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025518790
180 https://doi.org/10.1038/ki.1987.123
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/ki.1987.288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023607228
183 https://doi.org/10.1038/ki.1987.288
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/ki.1988.224 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008590465
186 https://doi.org/10.1038/ki.1988.224
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/ki.1992.221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029360728
189 https://doi.org/10.1038/ki.1992.221
190 rdf:type schema:CreativeWork
191 https://app.dimensions.ai/details/publication/pub.1075765047 schema:CreativeWork
192 https://app.dimensions.ai/details/publication/pub.1078897020 schema:CreativeWork
193 https://app.dimensions.ai/details/publication/pub.1079891557 schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1080012491 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1081622178 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1081636649 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1081686328 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1082102536 schema:CreativeWork
199 https://doi.org/10.1002/eji.1830140311 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051635975
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/eji.1830220110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034820409
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/0003-2697(76)90527-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025529346
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/0022-510x(88)90075-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009373991
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/s0140-6736(76)90480-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018838853
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1084/jem.148.1.246 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047255809
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1084/jem.162.1.117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025492434
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1084/jem.165.2.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037013974
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1084/jem.169.1.73 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004687466
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1084/jem.169.4.1373 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018233482
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1111/j.1365-3083.1989.tb01218.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017632770
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1111/j.1600-065x.1992.tb01421.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1021591427
222 rdf:type schema:CreativeWork
223 https://www.grid.ac/institutes/grid.416060.5 schema:alternateName Monash Medical Centre
224 schema:name Monash University, Department of Medicine, Monash Medical Centre, Clayton, Victoria, Australia.
225 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...