TNFα induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-10

AUTHORS

G Wolf, S Aberle, F Thaiss, P J Nelson, A M Krensky, E G Neilson, R A Stahl

ABSTRACT

We investigated the effect of several immune-relevant cytokines on expression of the chemoattractant intercrine/chemokine RANTES in a mouse mesangial cell line (MMC). Fifty ng/ml recombinant tumor necrosis factor alpha (TNF alpha) induced a marked increase in RANTES transcripts after two hours. RANTES mRNA remained elevated for 24 to 48 hours after stimulation, and could be abolished by co-incubation with 30 micrograms/ml of a neutralizing rabbit anti-TNF alpha antibody. Protein expression of RANTES, as assessed by indirect immunofluorescence and Western blotting, increased in MMCs 24 hours after TNF alpha stimulation. Interleukin-1 beta, tumor necrosis factor beta (TNF beta), and lipopolysaccharide (LPS) also increased expression of RANTES mRNA. In addition, RANTES mRNA expression was stimulated in glomeruli harvested from rats following renal in vivo perfusion with TNF alpha. Our results indicate that mesangial cells produce the small cytokine RANTES. This factor, in concert with other chemoattractants, may play a role in the glomerular recruitment of inflammatory cells like macrophages/monocytes. More... »

PAGES

795-804

References to SciGraph publications

  • 1992-03. Tumor necrosis factor alpha and mesangial cells in KIDNEY INTERNATIONAL
  • 1992-09. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β in KIDNEY INTERNATIONAL
  • 1992-01. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes in KIDNEY INTERNATIONAL
  • 1992-07. IL-1 receptor antagonist inhibits monocyte chemotactic peptide 1 generation by human mesangial cells in KIDNEY INTERNATIONAL
  • 1990-11. Contributions of mesangial cells to glomerular immune functions in JOURNAL OF MOLECULAR MEDICINE
  • 1991-07. Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8 in KIDNEY INTERNATIONAL
  • 1993. Increased Expression of Monocyte Chemoattractant Protein-1 (Mcp-1) in Glomeruli From Rats With Anti Thy 1.1 Glomerulonephritis in THE CHEMOKINES
  • 1992-07. Increased oxygen radical and eicosanoid formation in immune-mediated mesangial cell injury in KIDNEY INTERNATIONAL
  • 1989-05. Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide in KIDNEY INTERNATIONAL
  • 1990-10. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES in NATURE
  • 1984-07. Angiotensin II stimulation of prostaglandin E2 and 6-keto-F1α, formation by isolated human glomeruli in KIDNEY INTERNATIONAL
  • 1992-09. The inflammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system in JOURNAL OF MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ki.1993.314

    DOI

    http://dx.doi.org/10.1038/ki.1993.314

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030499157

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7505037


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