TNFα induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-10

AUTHORS

G Wolf, S Aberle, F Thaiss, P J Nelson, A M Krensky, E G Neilson, R A Stahl

ABSTRACT

We investigated the effect of several immune-relevant cytokines on expression of the chemoattractant intercrine/chemokine RANTES in a mouse mesangial cell line (MMC). Fifty ng/ml recombinant tumor necrosis factor alpha (TNF alpha) induced a marked increase in RANTES transcripts after two hours. RANTES mRNA remained elevated for 24 to 48 hours after stimulation, and could be abolished by co-incubation with 30 micrograms/ml of a neutralizing rabbit anti-TNF alpha antibody. Protein expression of RANTES, as assessed by indirect immunofluorescence and Western blotting, increased in MMCs 24 hours after TNF alpha stimulation. Interleukin-1 beta, tumor necrosis factor beta (TNF beta), and lipopolysaccharide (LPS) also increased expression of RANTES mRNA. In addition, RANTES mRNA expression was stimulated in glomeruli harvested from rats following renal in vivo perfusion with TNF alpha. Our results indicate that mesangial cells produce the small cytokine RANTES. This factor, in concert with other chemoattractants, may play a role in the glomerular recruitment of inflammatory cells like macrophages/monocytes. More... »

PAGES

795-804

References to SciGraph publications

  • 1992-03. Tumor necrosis factor alpha and mesangial cells in KIDNEY INTERNATIONAL
  • 1992-09. High glucose-induced proliferation in mesangial cells is reversed by autocrine TGF-β in KIDNEY INTERNATIONAL
  • 1992-01. Isolation and characterization of cDNA from renal tubular epithelium encoding murine Rantes in KIDNEY INTERNATIONAL
  • 1992-07. IL-1 receptor antagonist inhibits monocyte chemotactic peptide 1 generation by human mesangial cells in KIDNEY INTERNATIONAL
  • 1990-11. Contributions of mesangial cells to glomerular immune functions in JOURNAL OF MOLECULAR MEDICINE
  • 1991-07. Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8 in KIDNEY INTERNATIONAL
  • 1993. Increased Expression of Monocyte Chemoattractant Protein-1 (Mcp-1) in Glomeruli From Rats With Anti Thy 1.1 Glomerulonephritis in THE CHEMOKINES
  • 1992-07. Increased oxygen radical and eicosanoid formation in immune-mediated mesangial cell injury in KIDNEY INTERNATIONAL
  • 1989-05. Production of tumor necrosis factor by rat mesangial cells in response to bacterial lipopolysaccharide in KIDNEY INTERNATIONAL
  • 1990-10. Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES in NATURE
  • 1984-07. Angiotensin II stimulation of prostaglandin E2 and 6-keto-F1α, formation by isolated human glomeruli in KIDNEY INTERNATIONAL
  • 1992-09. The inflammatory function of renal glomerular mesangial cells and their interaction with the cellular immune system in JOURNAL OF MOLECULAR MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ki.1993.314

    DOI

    http://dx.doi.org/10.1038/ki.1993.314

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1030499157

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/7505037


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Immunology", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blotting, Northern", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Blotting, Western", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cells, Cultured", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemokine CCL5", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemotactic Factors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cytokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Fluorescent Antibody Technique", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Glomerular Mesangium", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Lymphokines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Mice", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Perfusion", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "RNA, Messenger", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Tumor Necrosis Factor-alpha", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Goethe University Frankfurt", 
              "id": "https://www.grid.ac/institutes/grid.7839.5", 
              "name": [
                "Department of Medicine, University of Frankfurt, Federal Republic of Germany."
              ], 
              "type": "Organization"
            }, 
            "familyName": "Wolf", 
            "givenName": "G", 
            "id": "sg:person.01334335003.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334335003.33"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Aberle", 
            "givenName": "S", 
            "type": "Person"
          }, 
          {
            "familyName": "Thaiss", 
            "givenName": "F", 
            "id": "sg:person.01024637706.17", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024637706.17"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Nelson", 
            "givenName": "P J", 
            "id": "sg:person.014321554777.49", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014321554777.49"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Krensky", 
            "givenName": "A M", 
            "id": "sg:person.01322023063.43", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322023063.43"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Neilson", 
            "givenName": "E G", 
            "id": "sg:person.01261253004.94", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94"
            ], 
            "type": "Person"
          }, 
          {
            "familyName": "Stahl", 
            "givenName": "R A", 
            "id": "sg:person.0714746563.51", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714746563.51"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1038/ki.1992.90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000482721", 
              "https://doi.org/10.1038/ki.1992.90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/1043-4666(91)90013-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001738655"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1992.31", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001994782", 
              "https://doi.org/10.1038/ki.1992.31"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00180754", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1007623404", 
              "https://doi.org/10.1007/bf00180754"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/nar/13.7.2485", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1008134818"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1991.184", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009131471", 
              "https://doi.org/10.1038/ki.1991.184"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci112815", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012937761"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01798065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014451790", 
              "https://doi.org/10.1007/bf01798065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01798065", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014451790", 
              "https://doi.org/10.1007/bf01798065"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1984.130", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015516854", 
              "https://doi.org/10.1038/ki.1984.130"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci112790", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1016276758"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/347669a0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017080895", 
              "https://doi.org/10.1038/347669a0"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0952-7915(91)90077-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018020175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0952-7915(91)90077-e", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018020175"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.165.3.601", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1021923596"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1989.98", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023438852", 
              "https://doi.org/10.1038/ki.1989.98"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1073/pnas.89.5.1745", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023833510"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1146/annurev.iy.09.040191.003153", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1025252869"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2730199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026594294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1042/bj2730199", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026594294"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci114265", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029809234"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/s0025-7125(16)31130-0", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029904903"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4615-2952-1_63", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039035042", 
              "https://doi.org/10.1007/978-1-4615-2952-1_63"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0014-5793(88)80543-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040759424"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1084/jem.176.2.587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041083321"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(90)90035-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041402806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0167-5699(90)90035-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041402806"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1992.330", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042450918", 
              "https://doi.org/10.1038/ki.1992.330"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1002/eji.1830220621", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1044344018"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1992.262", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1046263500", 
              "https://doi.org/10.1038/ki.1992.262"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/0076-6879(90)82008-p", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047549191"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/ki.1992.266", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050407030", 
              "https://doi.org/10.1038/ki.1992.266"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1172/jci115939", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1051319664"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1076881199", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1152/ajprenal.1990.259.5.f768", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1077302471"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077375741", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078179838", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1078293585", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1079453138", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1081854636", 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "1993-10", 
        "datePublishedReg": "1993-10-01", 
        "description": "We investigated the effect of several immune-relevant cytokines on expression of the chemoattractant intercrine/chemokine RANTES in a mouse mesangial cell line (MMC). Fifty ng/ml recombinant tumor necrosis factor alpha (TNF alpha) induced a marked increase in RANTES transcripts after two hours. RANTES mRNA remained elevated for 24 to 48 hours after stimulation, and could be abolished by co-incubation with 30 micrograms/ml of a neutralizing rabbit anti-TNF alpha antibody. Protein expression of RANTES, as assessed by indirect immunofluorescence and Western blotting, increased in MMCs 24 hours after TNF alpha stimulation. Interleukin-1 beta, tumor necrosis factor beta (TNF beta), and lipopolysaccharide (LPS) also increased expression of RANTES mRNA. In addition, RANTES mRNA expression was stimulated in glomeruli harvested from rats following renal in vivo perfusion with TNF alpha. Our results indicate that mesangial cells produce the small cytokine RANTES. This factor, in concert with other chemoattractants, may play a role in the glomerular recruitment of inflammatory cells like macrophages/monocytes.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1038/ki.1993.314", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": true, 
        "isPartOf": [
          {
            "id": "sg:journal.1015319", 
            "issn": [
              "0085-2538", 
              "1523-1755"
            ], 
            "name": "Kidney International", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "4", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "44"
          }
        ], 
        "name": "TNF\u03b1 induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells", 
        "pagination": "795-804", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "914b8a162206593fa2d2ca804a5c54eb69cc0b411850fad1ac5c2e23947d6be3"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "7505037"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "0323470"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1038/ki.1993.314"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1030499157"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1038/ki.1993.314", 
          "https://app.dimensions.ai/details/publication/pub.1030499157"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-10T15:38", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000425.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "http://www.nature.com/ki/journal/v44/n4/abs/ki1993314a.html"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1993.314'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1993.314'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1993.314'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1993.314'


     

    This table displays all metadata directly associated to this object as RDF triples.

    274 TRIPLES      21 PREDICATES      79 URIs      35 LITERALS      23 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1038/ki.1993.314 schema:about N0f85e6f1cde84135a45c424dc52aae1c
    2 N1c33efcd6c794972a93c78112ab59389
    3 N2bc50422595d40a3bc0d85e6f2a3e8bf
    4 N30b74d8225a646df96c638e3cb34d7e9
    5 N5503f6974e664f7f9d1a709f259d3d83
    6 N78a119dec30441e192f1f56d8754d07c
    7 N7915834a00824f9aaab66ddde8f1717a
    8 N8e398d00233a4675b21c47fab7568de8
    9 N9dfa2110033445ee8119100b172d438e
    10 N9e2b43406cff4a31a4bf78d0ddda7f64
    11 Nbfbd0f073d944ff68e4a27cf7965ddf7
    12 Nd22f59fa756b495dac7237d988ea98c4
    13 Ndf844fbb7d5d48c2894c76c7f909bb3d
    14 Nec6e377cc4c84771a23f3b3ce0206036
    15 anzsrc-for:11
    16 anzsrc-for:1107
    17 schema:author N43775848cc244fd38b7608a8bb55a33b
    18 schema:citation sg:pub.10.1007/978-1-4615-2952-1_63
    19 sg:pub.10.1007/bf00180754
    20 sg:pub.10.1007/bf01798065
    21 sg:pub.10.1038/347669a0
    22 sg:pub.10.1038/ki.1984.130
    23 sg:pub.10.1038/ki.1989.98
    24 sg:pub.10.1038/ki.1991.184
    25 sg:pub.10.1038/ki.1992.262
    26 sg:pub.10.1038/ki.1992.266
    27 sg:pub.10.1038/ki.1992.31
    28 sg:pub.10.1038/ki.1992.330
    29 sg:pub.10.1038/ki.1992.90
    30 https://app.dimensions.ai/details/publication/pub.1076881199
    31 https://app.dimensions.ai/details/publication/pub.1077375741
    32 https://app.dimensions.ai/details/publication/pub.1078179838
    33 https://app.dimensions.ai/details/publication/pub.1078293585
    34 https://app.dimensions.ai/details/publication/pub.1079453138
    35 https://app.dimensions.ai/details/publication/pub.1081854636
    36 https://doi.org/10.1002/eji.1830220621
    37 https://doi.org/10.1016/0014-5793(88)80543-x
    38 https://doi.org/10.1016/0076-6879(90)82008-p
    39 https://doi.org/10.1016/0167-5699(90)90035-8
    40 https://doi.org/10.1016/0952-7915(91)90077-e
    41 https://doi.org/10.1016/1043-4666(91)90013-4
    42 https://doi.org/10.1016/s0025-7125(16)31130-0
    43 https://doi.org/10.1042/bj2730199
    44 https://doi.org/10.1073/pnas.89.5.1745
    45 https://doi.org/10.1084/jem.165.3.601
    46 https://doi.org/10.1084/jem.176.2.587
    47 https://doi.org/10.1093/nar/13.7.2485
    48 https://doi.org/10.1146/annurev.iy.09.040191.003153
    49 https://doi.org/10.1152/ajprenal.1990.259.5.f768
    50 https://doi.org/10.1172/jci112790
    51 https://doi.org/10.1172/jci112815
    52 https://doi.org/10.1172/jci114265
    53 https://doi.org/10.1172/jci115939
    54 schema:datePublished 1993-10
    55 schema:datePublishedReg 1993-10-01
    56 schema:description We investigated the effect of several immune-relevant cytokines on expression of the chemoattractant intercrine/chemokine RANTES in a mouse mesangial cell line (MMC). Fifty ng/ml recombinant tumor necrosis factor alpha (TNF alpha) induced a marked increase in RANTES transcripts after two hours. RANTES mRNA remained elevated for 24 to 48 hours after stimulation, and could be abolished by co-incubation with 30 micrograms/ml of a neutralizing rabbit anti-TNF alpha antibody. Protein expression of RANTES, as assessed by indirect immunofluorescence and Western blotting, increased in MMCs 24 hours after TNF alpha stimulation. Interleukin-1 beta, tumor necrosis factor beta (TNF beta), and lipopolysaccharide (LPS) also increased expression of RANTES mRNA. In addition, RANTES mRNA expression was stimulated in glomeruli harvested from rats following renal in vivo perfusion with TNF alpha. Our results indicate that mesangial cells produce the small cytokine RANTES. This factor, in concert with other chemoattractants, may play a role in the glomerular recruitment of inflammatory cells like macrophages/monocytes.
    57 schema:genre research_article
    58 schema:inLanguage en
    59 schema:isAccessibleForFree true
    60 schema:isPartOf N684293606fa44c288e1d6be139881050
    61 N7a0875029bef462c81f6e735df25df53
    62 sg:journal.1015319
    63 schema:name TNFα induces expression of the chemoattractant cytokine RANTES in cultured mouse mesangial cells
    64 schema:pagination 795-804
    65 schema:productId N1e01897dfd6f4a58bee63848ee32f79c
    66 N538f3d043c244da2a59d292020d27acb
    67 N546c092480294dc9a2ede1edefca3283
    68 Ne15836fd9b8446c7a4901f54257a5191
    69 Nea0a60f8c3c04790a325a7ef9920d880
    70 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030499157
    71 https://doi.org/10.1038/ki.1993.314
    72 schema:sdDatePublished 2019-04-10T15:38
    73 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    74 schema:sdPublisher Nd069d7c6b65c49609dab27e661599df7
    75 schema:url http://www.nature.com/ki/journal/v44/n4/abs/ki1993314a.html
    76 sgo:license sg:explorer/license/
    77 sgo:sdDataset articles
    78 rdf:type schema:ScholarlyArticle
    79 N0f85e6f1cde84135a45c424dc52aae1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    80 schema:name Cytokines
    81 rdf:type schema:DefinedTerm
    82 N143b110173d74f2397520e063ec350fd rdf:first sg:person.014321554777.49
    83 rdf:rest Nfcc5bac5c3f94e3292bf5bcce62096ed
    84 N1c33efcd6c794972a93c78112ab59389 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    85 schema:name Blotting, Western
    86 rdf:type schema:DefinedTerm
    87 N1e01897dfd6f4a58bee63848ee32f79c schema:name doi
    88 schema:value 10.1038/ki.1993.314
    89 rdf:type schema:PropertyValue
    90 N2bc50422595d40a3bc0d85e6f2a3e8bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    91 schema:name Perfusion
    92 rdf:type schema:DefinedTerm
    93 N30b74d8225a646df96c638e3cb34d7e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    94 schema:name Tumor Necrosis Factor-alpha
    95 rdf:type schema:DefinedTerm
    96 N43775848cc244fd38b7608a8bb55a33b rdf:first sg:person.01334335003.33
    97 rdf:rest N7e634faa9a90405b8db279d560a734dc
    98 N4bc6635814654d519f2a6f53c5555ff3 schema:familyName Aberle
    99 schema:givenName S
    100 rdf:type schema:Person
    101 N538f3d043c244da2a59d292020d27acb schema:name nlm_unique_id
    102 schema:value 0323470
    103 rdf:type schema:PropertyValue
    104 N546c092480294dc9a2ede1edefca3283 schema:name readcube_id
    105 schema:value 914b8a162206593fa2d2ca804a5c54eb69cc0b411850fad1ac5c2e23947d6be3
    106 rdf:type schema:PropertyValue
    107 N5503f6974e664f7f9d1a709f259d3d83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    108 schema:name Fluorescent Antibody Technique
    109 rdf:type schema:DefinedTerm
    110 N684293606fa44c288e1d6be139881050 schema:volumeNumber 44
    111 rdf:type schema:PublicationVolume
    112 N78a119dec30441e192f1f56d8754d07c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    113 schema:name Chemokine CCL5
    114 rdf:type schema:DefinedTerm
    115 N7915834a00824f9aaab66ddde8f1717a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    116 schema:name Glomerular Mesangium
    117 rdf:type schema:DefinedTerm
    118 N7a0875029bef462c81f6e735df25df53 schema:issueNumber 4
    119 rdf:type schema:PublicationIssue
    120 N7e634faa9a90405b8db279d560a734dc rdf:first N4bc6635814654d519f2a6f53c5555ff3
    121 rdf:rest Nac90c8b60e8b4706838648d9a93dc4b6
    122 N8e398d00233a4675b21c47fab7568de8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    123 schema:name Animals
    124 rdf:type schema:DefinedTerm
    125 N9dfa2110033445ee8119100b172d438e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    126 schema:name RNA, Messenger
    127 rdf:type schema:DefinedTerm
    128 N9e2b43406cff4a31a4bf78d0ddda7f64 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    129 schema:name Mice
    130 rdf:type schema:DefinedTerm
    131 Nac90c8b60e8b4706838648d9a93dc4b6 rdf:first sg:person.01024637706.17
    132 rdf:rest N143b110173d74f2397520e063ec350fd
    133 Nbfbd0f073d944ff68e4a27cf7965ddf7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    134 schema:name Lymphokines
    135 rdf:type schema:DefinedTerm
    136 Nc37b0ae007f14f5bbc7ef9e40bc119a6 rdf:first sg:person.0714746563.51
    137 rdf:rest rdf:nil
    138 Nd069d7c6b65c49609dab27e661599df7 schema:name Springer Nature - SN SciGraph project
    139 rdf:type schema:Organization
    140 Nd22f59fa756b495dac7237d988ea98c4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    141 schema:name Blotting, Northern
    142 rdf:type schema:DefinedTerm
    143 Ndf844fbb7d5d48c2894c76c7f909bb3d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    144 schema:name Chemotactic Factors
    145 rdf:type schema:DefinedTerm
    146 Ne15836fd9b8446c7a4901f54257a5191 schema:name pubmed_id
    147 schema:value 7505037
    148 rdf:type schema:PropertyValue
    149 Ne24277ee3e6542dea0de02745e57b1df rdf:first sg:person.01261253004.94
    150 rdf:rest Nc37b0ae007f14f5bbc7ef9e40bc119a6
    151 Nea0a60f8c3c04790a325a7ef9920d880 schema:name dimensions_id
    152 schema:value pub.1030499157
    153 rdf:type schema:PropertyValue
    154 Nec6e377cc4c84771a23f3b3ce0206036 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    155 schema:name Cells, Cultured
    156 rdf:type schema:DefinedTerm
    157 Nfcc5bac5c3f94e3292bf5bcce62096ed rdf:first sg:person.01322023063.43
    158 rdf:rest Ne24277ee3e6542dea0de02745e57b1df
    159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    160 schema:name Medical and Health Sciences
    161 rdf:type schema:DefinedTerm
    162 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
    163 schema:name Immunology
    164 rdf:type schema:DefinedTerm
    165 sg:journal.1015319 schema:issn 0085-2538
    166 1523-1755
    167 schema:name Kidney International
    168 rdf:type schema:Periodical
    169 sg:person.01024637706.17 schema:familyName Thaiss
    170 schema:givenName F
    171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01024637706.17
    172 rdf:type schema:Person
    173 sg:person.01261253004.94 schema:familyName Neilson
    174 schema:givenName E G
    175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01261253004.94
    176 rdf:type schema:Person
    177 sg:person.01322023063.43 schema:familyName Krensky
    178 schema:givenName A M
    179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01322023063.43
    180 rdf:type schema:Person
    181 sg:person.01334335003.33 schema:affiliation https://www.grid.ac/institutes/grid.7839.5
    182 schema:familyName Wolf
    183 schema:givenName G
    184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01334335003.33
    185 rdf:type schema:Person
    186 sg:person.014321554777.49 schema:familyName Nelson
    187 schema:givenName P J
    188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014321554777.49
    189 rdf:type schema:Person
    190 sg:person.0714746563.51 schema:familyName Stahl
    191 schema:givenName R A
    192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714746563.51
    193 rdf:type schema:Person
    194 sg:pub.10.1007/978-1-4615-2952-1_63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039035042
    195 https://doi.org/10.1007/978-1-4615-2952-1_63
    196 rdf:type schema:CreativeWork
    197 sg:pub.10.1007/bf00180754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007623404
    198 https://doi.org/10.1007/bf00180754
    199 rdf:type schema:CreativeWork
    200 sg:pub.10.1007/bf01798065 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014451790
    201 https://doi.org/10.1007/bf01798065
    202 rdf:type schema:CreativeWork
    203 sg:pub.10.1038/347669a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017080895
    204 https://doi.org/10.1038/347669a0
    205 rdf:type schema:CreativeWork
    206 sg:pub.10.1038/ki.1984.130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015516854
    207 https://doi.org/10.1038/ki.1984.130
    208 rdf:type schema:CreativeWork
    209 sg:pub.10.1038/ki.1989.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438852
    210 https://doi.org/10.1038/ki.1989.98
    211 rdf:type schema:CreativeWork
    212 sg:pub.10.1038/ki.1991.184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009131471
    213 https://doi.org/10.1038/ki.1991.184
    214 rdf:type schema:CreativeWork
    215 sg:pub.10.1038/ki.1992.262 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046263500
    216 https://doi.org/10.1038/ki.1992.262
    217 rdf:type schema:CreativeWork
    218 sg:pub.10.1038/ki.1992.266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050407030
    219 https://doi.org/10.1038/ki.1992.266
    220 rdf:type schema:CreativeWork
    221 sg:pub.10.1038/ki.1992.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001994782
    222 https://doi.org/10.1038/ki.1992.31
    223 rdf:type schema:CreativeWork
    224 sg:pub.10.1038/ki.1992.330 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042450918
    225 https://doi.org/10.1038/ki.1992.330
    226 rdf:type schema:CreativeWork
    227 sg:pub.10.1038/ki.1992.90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000482721
    228 https://doi.org/10.1038/ki.1992.90
    229 rdf:type schema:CreativeWork
    230 https://app.dimensions.ai/details/publication/pub.1076881199 schema:CreativeWork
    231 https://app.dimensions.ai/details/publication/pub.1077375741 schema:CreativeWork
    232 https://app.dimensions.ai/details/publication/pub.1078179838 schema:CreativeWork
    233 https://app.dimensions.ai/details/publication/pub.1078293585 schema:CreativeWork
    234 https://app.dimensions.ai/details/publication/pub.1079453138 schema:CreativeWork
    235 https://app.dimensions.ai/details/publication/pub.1081854636 schema:CreativeWork
    236 https://doi.org/10.1002/eji.1830220621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044344018
    237 rdf:type schema:CreativeWork
    238 https://doi.org/10.1016/0014-5793(88)80543-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040759424
    239 rdf:type schema:CreativeWork
    240 https://doi.org/10.1016/0076-6879(90)82008-p schema:sameAs https://app.dimensions.ai/details/publication/pub.1047549191
    241 rdf:type schema:CreativeWork
    242 https://doi.org/10.1016/0167-5699(90)90035-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041402806
    243 rdf:type schema:CreativeWork
    244 https://doi.org/10.1016/0952-7915(91)90077-e schema:sameAs https://app.dimensions.ai/details/publication/pub.1018020175
    245 rdf:type schema:CreativeWork
    246 https://doi.org/10.1016/1043-4666(91)90013-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001738655
    247 rdf:type schema:CreativeWork
    248 https://doi.org/10.1016/s0025-7125(16)31130-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029904903
    249 rdf:type schema:CreativeWork
    250 https://doi.org/10.1042/bj2730199 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026594294
    251 rdf:type schema:CreativeWork
    252 https://doi.org/10.1073/pnas.89.5.1745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023833510
    253 rdf:type schema:CreativeWork
    254 https://doi.org/10.1084/jem.165.3.601 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021923596
    255 rdf:type schema:CreativeWork
    256 https://doi.org/10.1084/jem.176.2.587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041083321
    257 rdf:type schema:CreativeWork
    258 https://doi.org/10.1093/nar/13.7.2485 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008134818
    259 rdf:type schema:CreativeWork
    260 https://doi.org/10.1146/annurev.iy.09.040191.003153 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025252869
    261 rdf:type schema:CreativeWork
    262 https://doi.org/10.1152/ajprenal.1990.259.5.f768 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077302471
    263 rdf:type schema:CreativeWork
    264 https://doi.org/10.1172/jci112790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016276758
    265 rdf:type schema:CreativeWork
    266 https://doi.org/10.1172/jci112815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012937761
    267 rdf:type schema:CreativeWork
    268 https://doi.org/10.1172/jci114265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029809234
    269 rdf:type schema:CreativeWork
    270 https://doi.org/10.1172/jci115939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051319664
    271 rdf:type schema:CreativeWork
    272 https://www.grid.ac/institutes/grid.7839.5 schema:alternateName Goethe University Frankfurt
    273 schema:name Department of Medicine, University of Frankfurt, Federal Republic of Germany.
    274 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...