Gene expression of interleukin-1β during hemodialysis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1993-03

AUTHORS

R Schindler, S Linnenweber, M Schulze, M Oppermann, C A Dinarello, S Shaldon, K M Koch

ABSTRACT

It is still controversial whether the hemodialysis (HD) procedure is an inflammatory process in vivo. Therefore, we studied the gene expression of interleukin-1 beta (IL-1 beta) as a marker of inflammation in peripheral blood mononuclear cells (PBMC) of patients during HD by Northern blotting and polymerase chain reaction. Compared to PBMC separated pre-HD (1.0 densitometric units), the amount of IL-1 beta mRNA was increased in PBMC leaving the dialyzer (12.2 +/- 2 densitometric units, P < 0.01), but was not increased in PBMC re-entering the dialyzer from the systemic circulation (0.6 +/- 0.1 densitometric units) in all 12 patients studied. The maximal amount of IL-1 beta mRNA in PBMC was seen at five minutes after start of HD. There was a significant correlation between the increase in IL-1 beta mRNA and the increase in activated complement C5a (r = 0.71, P < 0.01). HD using less complement-activating membranes (hemophan, polysulfone, polyamide or polyacrylonitrile) resulted in no detectable IL-1 beta mRNA. Furthermore, a monoclonal antibody against human C5a reduced the increase in IL-1 beta mRNA by 83% (P < 0.05), indicating that C5a plays a major role for induction of IL-1 beta mRNA during HD. This study demonstrates that during HD with regenerated cellulose, gene expression for IL-1 beta takes place in PBMC. More... »

PAGES

712-721

References to SciGraph publications

  • 1990-01. Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor in NATURE
  • 1991-12. Tumor necrosis factor (TNFα) binding protein: Interference in immunoassays of TNFα in KIDNEY INTERNATIONAL
  • 1990-07. Plasma and muscle free amino acids in maintenance hemodialysis patients without protein malnutrition in KIDNEY INTERNATIONAL
  • 1987-07. Blood–membrane interaction in hemodialysis leads to increased cytokine production in KIDNEY INTERNATIONAL
  • 1988-09. Complement activation in patients with renal failure as detected through the quantitation of fragments of the complement proteins C3, C5, and factor B in JOURNAL OF MOLECULAR MEDICINE
  • 1990-09. Effect of in vivo contact between blood and dialysis membranes on protein catabolism in humans in KIDNEY INTERNATIONAL
  • 1983-12. Anaphylatoxin formation during hemodialysis: Effects of different dialyzer membranes in KIDNEY INTERNATIONAL
  • 1990-01. Transcription, not synthesis, of interleukin-1 and tumor necrosis factor by complement in KIDNEY INTERNATIONAL
  • 1992-07. Permeability of dialyzer membranes to TNFα-inducing substances derived from water bacteria in KIDNEY INTERNATIONAL
  • 1988-07. Cuprammonium membranes stimulate interleukin 1 release and arachidonic acid metabolism in monocytes in the absence of complement in KIDNEY INTERNATIONAL
  • 1990-01. Influence of uremia and hemodialysis on circulating interleukin-1 and tumor necrosis factor α in KIDNEY INTERNATIONAL
  • 1990-11. Effects of dialysis membranes on beta2-mieroglobulin production and cellular expression in KIDNEY INTERNATIONAL
  • 1989-05. In vivo induction of interleukin-1 during hemodialysis in KIDNEY INTERNATIONAL
  • 1991-10. Anti-interleukin-1α autoantibodies in hemodialysis patients in KIDNEY INTERNATIONAL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ki.1993.102

    DOI

    http://dx.doi.org/10.1038/ki.1993.102

    DIMENSIONS

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    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/8455371


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