Arginase is a major pathway of L-arginine metabolism in nephritic glomeruli View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-11

AUTHORS

Albertine Jansen, Simon Lewis, Victoria Cattell, H. Terence Cook

ABSTRACT

L-arginine can be metabolized to nitric oxide (NO) by nitric oxide synthase (NOS) and to urea and L-ornithine by arginase. Competition between these pathways for L-arginine in inflammatory sites has been suggested. In experimental glomerulonephritis glomeruli produce nitrite; a major source is macrophages. We hypothesized that arginase is present in glomeruli and may compete for substrate with NOS in glomerulonephritis. Therefore we examined both pathways in isolated nephritic glomeruli and peritoneal macrophages. Arginase activity was present in glomeruli, increased by > 500% in nephritic glomeruli compared to controls, and was predominant over NOS. Activity increased with L-NMMA (a NOS inhibitor), but this trend did not reach statistical significance. In macrophages both pathways were present; NOS predominated basally but this was reversed by L-NMMA. In contrast with glomeruli macrophage arginase activity increased after LPS stimulation. Levels of macrophage arginase activity could not account for activity in nephritic glomeruli, suggesting another source of arginase. This is the first demonstration of high arginase activity of nephritic glomeruli. Competition between arginase and NOS pathways suggests a regulatory mechanism of L-arginine metabolism within the glomerulus, with implications for the pathogenesis of injury and scarring in glomerulonephritis. More... »

PAGES

1107-1112

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1992.394

DOI

http://dx.doi.org/10.1038/ki.1992.394

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1280702


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