Mesangial expression of intercellular adhesion molecule-1 in primary glomerulosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1992-04

AUTHORS

A Dal Canton, G Fuiano, V Sepe, A Caglioti, S Ferrone

ABSTRACT

Frozen sections of renal biopsy specimens from eight patients with primary focal segmental glomerulosclerosis (FSGS) and 10 patients with membranous nephropathy (MN) were stained in immuno-peroxidase with the intercellular adhesion molecule-1 (ICAM-1) monoclonal antibody (MoAb), CL203.4. ICAM-1 was expressed by mesangial cells in six patients with FSGS. On the other hand, ICAM-1 was not detected in mesangial cells in patients with MN or in the non-affected portion of tumoral kidneys used to control normal renal expression of ICAM-1. De novo mesangial expression of ICAM-1 in FSGS suggests that sclerosis results from an inflammatory process, possibly associated with local release of cytokines. More... »

PAGES

951-955

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1992.145

DOI

http://dx.doi.org/10.1038/ki.1992.145

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002091720

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1381006


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