Cytokine-activated human mesangial cells generate the neutrophil chemoattractant, interleukin 8 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-07

AUTHORS

Z Brown, R M Strieter, S W Chensue, M Ceska, I Lindley, G H Neild, S L Kunkel, J Westwick

ABSTRACT

Human mesangial cells (MC) in culture, when stimulated by interleukin 1 alpha(IL-1 alpha) or tumour necrosis factor (TNF alpha), but not with lipopolysaccharide (LPS), express interleukin 8 (IL-8) mRNA, and both cell associated and extracellular IL-8. Dexamethasone treatment of mesangial cells induced partial inhibition of the release of extracellular IL-8, while cell-associated IL-8 and IL-8 mRNA were not significantly altered. We propose that the mesangial cell has a direct role in the initiation and propagation of inflammatory events within the glomerulus via the generation of the chemotactic cytokine IL-8. More... »

PAGES

86-90

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1991.184

DOI

http://dx.doi.org/10.1038/ki.1991.184

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009131471

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1921160


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