Desferrioxamine regulates tumor necrosis factor release in mesangial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1991-05

AUTHORS

H Affres, J Perez, J Hagege, B Fouqueray, M Kornprobst, R Ardaillou, L Baud

ABSTRACT

Cultured rat mesangial cells have been demonstrated to express tumor necrosis factor alpha (TNF alpha) mRNA and to release TNF activity into the medium upon stimulation by bacterial lipopolysaccharide (LPS). The present study was undertaken to determine whether TNF was only secreted by mesangial cells or was also present as a cell-associated molecule. LPS-activated mesangial cells which had been fixed in paraformaldehyde lysed the TNF-sensitive L-929 fibroblasts, as assessed by 51Cr release. This cytotoxic activity was inhibited by anti-TNF alpha antiserum. Cell-associated TNF expression was demonstrable after less than one hour of exposure to LPS, peaked at two hours and decreased progressively thereafter, while TNF activity increased in the medium. Mesangial cell-associated TNF was localized at the cell surface, as shown by immunohistochemical demonstration and by the ability of plasma membranes purified from LPS-activated mesangial cells to lyse L-929 fibroblasts. Flow cytometry experiments revealed that two-thirds of LPS-activated mesangial cells were stained by anti-TNF alpha antiserum. The major part of these cell-associated TNF molecules persisted after low pH treatment, indicating that they were integral membrane proteins. As assessed by immunoprecipitation analysis, these proteins were 26 kDa molecules, whereas the released forms of TNF were 17 kDa molecules. Pretreatment of mesangial cells with desferrioxamine (DFX), an iron chelator preventing the synthesis of hydroxyl radicals (OH.), delayed the release of TNF from the membranes into the medium, and enhanced its cell surface expression. It also subsequently accelerated its decay in the medium.(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

822-830

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1991.103

DOI

http://dx.doi.org/10.1038/ki.1991.103

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039895155

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2067199


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Membrane", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deferoxamine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Flow Cytometry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Mesangium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunoenzyme Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Immunohistochemistry", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lipopolysaccharides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Unit\u00e9 64, H\u00f4pital Tenon, Paris, France."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Affres", 
        "givenName": "H", 
        "id": "sg:person.014343447774.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014343447774.90"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Perez", 
        "givenName": "J", 
        "id": "sg:person.01023461464.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023461464.25"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Hagege", 
        "givenName": "J", 
        "id": "sg:person.01250745444.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250745444.20"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Fouqueray", 
        "givenName": "B", 
        "id": "sg:person.01310645471.94", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310645471.94"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Kornprobst", 
        "givenName": "M", 
        "type": "Person"
      }, 
      {
        "familyName": "Ardaillou", 
        "givenName": "R", 
        "id": "sg:person.01333204126.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333204126.68"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Baud", 
        "givenName": "L", 
        "id": "sg:person.01242532271.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242532271.97"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/ki.1990.59", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001035371", 
          "https://doi.org/10.1038/ki.1990.59"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1990.44", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008105625", 
          "https://doi.org/10.1038/ki.1990.44"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/34.7.3458811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011784733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/34.7.3458811", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011784733"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.158.6.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013516845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1164/ajrccm/139.4.1010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013753601"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci112790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016276758"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023438852", 
          "https://doi.org/10.1038/ki.1989.98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(90)90816-w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031069718"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-2776(08)60846-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032470215"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1990.112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037653161", 
          "https://doi.org/10.1038/ki.1990.112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038255941", 
          "https://doi.org/10.1038/ki.1988.141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(88)90486-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038588184"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(88)80543-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040759424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.86.3.1056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042488821"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1990.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049358760", 
          "https://doi.org/10.1038/ki.1990.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049591240", 
          "https://doi.org/10.1038/ki.1989.264"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physrev.1990.70.2.427", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077283513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078928291", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078946914", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079003229", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079025017", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079160954", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079306197", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079353892", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079414741", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079507400", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1986.251.5.f765", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079511505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079519938", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079572465", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079588153", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079610032", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079646637", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647844", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1991-05", 
    "datePublishedReg": "1991-05-01", 
    "description": "Cultured rat mesangial cells have been demonstrated to express tumor necrosis factor alpha (TNF alpha) mRNA and to release TNF activity into the medium upon stimulation by bacterial lipopolysaccharide (LPS). The present study was undertaken to determine whether TNF was only secreted by mesangial cells or was also present as a cell-associated molecule. LPS-activated mesangial cells which had been fixed in paraformaldehyde lysed the TNF-sensitive L-929 fibroblasts, as assessed by 51Cr release. This cytotoxic activity was inhibited by anti-TNF alpha antiserum. Cell-associated TNF expression was demonstrable after less than one hour of exposure to LPS, peaked at two hours and decreased progressively thereafter, while TNF activity increased in the medium. Mesangial cell-associated TNF was localized at the cell surface, as shown by immunohistochemical demonstration and by the ability of plasma membranes purified from LPS-activated mesangial cells to lyse L-929 fibroblasts. Flow cytometry experiments revealed that two-thirds of LPS-activated mesangial cells were stained by anti-TNF alpha antiserum. The major part of these cell-associated TNF molecules persisted after low pH treatment, indicating that they were integral membrane proteins. As assessed by immunoprecipitation analysis, these proteins were 26 kDa molecules, whereas the released forms of TNF were 17 kDa molecules. Pretreatment of mesangial cells with desferrioxamine (DFX), an iron chelator preventing the synthesis of hydroxyl radicals (OH.), delayed the release of TNF from the membranes into the medium, and enhanced its cell surface expression. It also subsequently accelerated its decay in the medium.(ABSTRACT TRUNCATED AT 250 WORDS)", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1991.103", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "39"
      }
    ], 
    "name": "Desferrioxamine regulates tumor necrosis factor release in mesangial cells", 
    "pagination": "822-830", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "be0affeb9ed42297c0064a46c9c4b4238e2f3fe6148da78280bf525cda4b3955"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2067199"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1991.103"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039895155"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1991.103", 
      "https://app.dimensions.ai/details/publication/pub.1039895155"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T12:59", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8659_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v39/n5/abs/ki1991103a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1991.103'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1991.103'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1991.103'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1991.103'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      75 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1991.103 schema:about N28b5053cbb48443f952477bc2674b764
2 N2e66e53e0ced4dd3879e8d779581bb13
3 N657d3ed8d73f4decad79a4a5e33f971e
4 N7d4118c7a72b41078d0dac25cc4d33a3
5 N81f5974ff3d346b18492711d066f5bbc
6 N90afd373a3694f2087575ca6418e3f9c
7 Naf40e77c64f74918ad6afd426bdba971
8 Nbbab6ce149394e3aaa620cd16699ba67
9 Ncae2f5380c5e4091afa971fd5546e515
10 Nd62daf81d3ec4c92961e23f88ede4d38
11 Ne0528f45591c4362a972f82dcccba3e0
12 Nec562d267ac4455ba4b3131341f117bf
13 anzsrc-for:06
14 anzsrc-for:0601
15 schema:author Ne2f1f7de52674b6ca1cd7b53b00d09dd
16 schema:citation sg:pub.10.1038/ki.1988.141
17 sg:pub.10.1038/ki.1989.264
18 sg:pub.10.1038/ki.1989.98
19 sg:pub.10.1038/ki.1990.112
20 sg:pub.10.1038/ki.1990.44
21 sg:pub.10.1038/ki.1990.46
22 sg:pub.10.1038/ki.1990.59
23 https://app.dimensions.ai/details/publication/pub.1076750128
24 https://app.dimensions.ai/details/publication/pub.1078928291
25 https://app.dimensions.ai/details/publication/pub.1078946914
26 https://app.dimensions.ai/details/publication/pub.1079003229
27 https://app.dimensions.ai/details/publication/pub.1079025017
28 https://app.dimensions.ai/details/publication/pub.1079160954
29 https://app.dimensions.ai/details/publication/pub.1079306197
30 https://app.dimensions.ai/details/publication/pub.1079353892
31 https://app.dimensions.ai/details/publication/pub.1079414741
32 https://app.dimensions.ai/details/publication/pub.1079507400
33 https://app.dimensions.ai/details/publication/pub.1079519938
34 https://app.dimensions.ai/details/publication/pub.1079572465
35 https://app.dimensions.ai/details/publication/pub.1079588153
36 https://app.dimensions.ai/details/publication/pub.1079610032
37 https://app.dimensions.ai/details/publication/pub.1079646637
38 https://app.dimensions.ai/details/publication/pub.1079647844
39 https://doi.org/10.1016/0014-5793(88)80543-x
40 https://doi.org/10.1016/0092-8674(88)90486-2
41 https://doi.org/10.1016/0092-8674(90)90816-w
42 https://doi.org/10.1016/s0065-2776(08)60846-9
43 https://doi.org/10.1073/pnas.86.3.1056
44 https://doi.org/10.1084/jem.158.6.1836
45 https://doi.org/10.1152/ajprenal.1986.251.5.f765
46 https://doi.org/10.1152/physrev.1990.70.2.427
47 https://doi.org/10.1164/ajrccm/139.4.1010
48 https://doi.org/10.1172/jci112790
49 https://doi.org/10.1177/34.7.3458811
50 schema:datePublished 1991-05
51 schema:datePublishedReg 1991-05-01
52 schema:description Cultured rat mesangial cells have been demonstrated to express tumor necrosis factor alpha (TNF alpha) mRNA and to release TNF activity into the medium upon stimulation by bacterial lipopolysaccharide (LPS). The present study was undertaken to determine whether TNF was only secreted by mesangial cells or was also present as a cell-associated molecule. LPS-activated mesangial cells which had been fixed in paraformaldehyde lysed the TNF-sensitive L-929 fibroblasts, as assessed by 51Cr release. This cytotoxic activity was inhibited by anti-TNF alpha antiserum. Cell-associated TNF expression was demonstrable after less than one hour of exposure to LPS, peaked at two hours and decreased progressively thereafter, while TNF activity increased in the medium. Mesangial cell-associated TNF was localized at the cell surface, as shown by immunohistochemical demonstration and by the ability of plasma membranes purified from LPS-activated mesangial cells to lyse L-929 fibroblasts. Flow cytometry experiments revealed that two-thirds of LPS-activated mesangial cells were stained by anti-TNF alpha antiserum. The major part of these cell-associated TNF molecules persisted after low pH treatment, indicating that they were integral membrane proteins. As assessed by immunoprecipitation analysis, these proteins were 26 kDa molecules, whereas the released forms of TNF were 17 kDa molecules. Pretreatment of mesangial cells with desferrioxamine (DFX), an iron chelator preventing the synthesis of hydroxyl radicals (OH.), delayed the release of TNF from the membranes into the medium, and enhanced its cell surface expression. It also subsequently accelerated its decay in the medium.(ABSTRACT TRUNCATED AT 250 WORDS)
53 schema:genre research_article
54 schema:inLanguage en
55 schema:isAccessibleForFree true
56 schema:isPartOf N6bcce78daa06446e859cd1a6d41c7fbe
57 Nb4546e0aa15445a78e64a03247d47f31
58 sg:journal.1015319
59 schema:name Desferrioxamine regulates tumor necrosis factor release in mesangial cells
60 schema:pagination 822-830
61 schema:productId N2a29730f0fff457f8c7e7c18c0ba3731
62 N41bd0061b12e4458bb04e4feae83928d
63 Nb30712b4690541d5853a4b404cd3cc51
64 Nf0613e656107476f863a79652a1d079d
65 Nf1b21c60566f40fc9790515e2fd14f70
66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039895155
67 https://doi.org/10.1038/ki.1991.103
68 schema:sdDatePublished 2019-04-10T12:59
69 schema:sdLicense https://scigraph.springernature.com/explorer/license/
70 schema:sdPublisher N28228fe5221645b39d5498588c6e245e
71 schema:url http://www.nature.com/ki/journal/v39/n5/abs/ki1991103a.html
72 sgo:license sg:explorer/license/
73 sgo:sdDataset articles
74 rdf:type schema:ScholarlyArticle
75 N10019bb557454601bce4c83d9c57a4aa rdf:first sg:person.01333204126.68
76 rdf:rest Nc944270955fe432abc6da91adb921fa4
77 N28228fe5221645b39d5498588c6e245e schema:name Springer Nature - SN SciGraph project
78 rdf:type schema:Organization
79 N28b5053cbb48443f952477bc2674b764 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Immunohistochemistry
81 rdf:type schema:DefinedTerm
82 N2a29730f0fff457f8c7e7c18c0ba3731 schema:name pubmed_id
83 schema:value 2067199
84 rdf:type schema:PropertyValue
85 N2e66e53e0ced4dd3879e8d779581bb13 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name Animals
87 rdf:type schema:DefinedTerm
88 N41bd0061b12e4458bb04e4feae83928d schema:name doi
89 schema:value 10.1038/ki.1991.103
90 rdf:type schema:PropertyValue
91 N59bbd97deeac4f4d899ba1ca14f958cd schema:name Institut National de la Santé et de la Recherche Médicale, Unité 64, Hôpital Tenon, Paris, France.
92 rdf:type schema:Organization
93 N5d8efdd8eb7c483eababc70a421ffe7b schema:familyName Kornprobst
94 schema:givenName M
95 rdf:type schema:Person
96 N657d3ed8d73f4decad79a4a5e33f971e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Rats
98 rdf:type schema:DefinedTerm
99 N6bcce78daa06446e859cd1a6d41c7fbe schema:issueNumber 5
100 rdf:type schema:PublicationIssue
101 N6f58f51387794713a4d907033ec6f9d0 rdf:first sg:person.01310645471.94
102 rdf:rest Nbe0d4e5806e34c02a8211a67aa86aa24
103 N7d4118c7a72b41078d0dac25cc4d33a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Glomerular Mesangium
105 rdf:type schema:DefinedTerm
106 N81f5974ff3d346b18492711d066f5bbc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Deferoxamine
108 rdf:type schema:DefinedTerm
109 N90afd373a3694f2087575ca6418e3f9c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Flow Cytometry
111 rdf:type schema:DefinedTerm
112 N9a37f43a16714133826c9fb3b2ee9117 rdf:first sg:person.01023461464.25
113 rdf:rest Nb66909e95a3e439695a2c0c94bd68a5d
114 Naf40e77c64f74918ad6afd426bdba971 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Rats, Inbred Strains
116 rdf:type schema:DefinedTerm
117 Nb30712b4690541d5853a4b404cd3cc51 schema:name nlm_unique_id
118 schema:value 0323470
119 rdf:type schema:PropertyValue
120 Nb4546e0aa15445a78e64a03247d47f31 schema:volumeNumber 39
121 rdf:type schema:PublicationVolume
122 Nb66909e95a3e439695a2c0c94bd68a5d rdf:first sg:person.01250745444.20
123 rdf:rest N6f58f51387794713a4d907033ec6f9d0
124 Nbbab6ce149394e3aaa620cd16699ba67 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Tumor Necrosis Factor-alpha
126 rdf:type schema:DefinedTerm
127 Nbe0d4e5806e34c02a8211a67aa86aa24 rdf:first N5d8efdd8eb7c483eababc70a421ffe7b
128 rdf:rest N10019bb557454601bce4c83d9c57a4aa
129 Nc944270955fe432abc6da91adb921fa4 rdf:first sg:person.01242532271.97
130 rdf:rest rdf:nil
131 Ncae2f5380c5e4091afa971fd5546e515 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Lipopolysaccharides
133 rdf:type schema:DefinedTerm
134 Nd62daf81d3ec4c92961e23f88ede4d38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Immunoenzyme Techniques
136 rdf:type schema:DefinedTerm
137 Ne0528f45591c4362a972f82dcccba3e0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Cells, Cultured
139 rdf:type schema:DefinedTerm
140 Ne2f1f7de52674b6ca1cd7b53b00d09dd rdf:first sg:person.014343447774.90
141 rdf:rest N9a37f43a16714133826c9fb3b2ee9117
142 Nec562d267ac4455ba4b3131341f117bf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Cell Membrane
144 rdf:type schema:DefinedTerm
145 Nf0613e656107476f863a79652a1d079d schema:name readcube_id
146 schema:value be0affeb9ed42297c0064a46c9c4b4238e2f3fe6148da78280bf525cda4b3955
147 rdf:type schema:PropertyValue
148 Nf1b21c60566f40fc9790515e2fd14f70 schema:name dimensions_id
149 schema:value pub.1039895155
150 rdf:type schema:PropertyValue
151 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
152 schema:name Biological Sciences
153 rdf:type schema:DefinedTerm
154 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
155 schema:name Biochemistry and Cell Biology
156 rdf:type schema:DefinedTerm
157 sg:journal.1015319 schema:issn 0085-2538
158 1523-1755
159 schema:name Kidney International
160 rdf:type schema:Periodical
161 sg:person.01023461464.25 schema:familyName Perez
162 schema:givenName J
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023461464.25
164 rdf:type schema:Person
165 sg:person.01242532271.97 schema:familyName Baud
166 schema:givenName L
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01242532271.97
168 rdf:type schema:Person
169 sg:person.01250745444.20 schema:familyName Hagege
170 schema:givenName J
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01250745444.20
172 rdf:type schema:Person
173 sg:person.01310645471.94 schema:familyName Fouqueray
174 schema:givenName B
175 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01310645471.94
176 rdf:type schema:Person
177 sg:person.01333204126.68 schema:familyName Ardaillou
178 schema:givenName R
179 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01333204126.68
180 rdf:type schema:Person
181 sg:person.014343447774.90 schema:affiliation N59bbd97deeac4f4d899ba1ca14f958cd
182 schema:familyName Affres
183 schema:givenName H
184 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014343447774.90
185 rdf:type schema:Person
186 sg:pub.10.1038/ki.1988.141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038255941
187 https://doi.org/10.1038/ki.1988.141
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/ki.1989.264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049591240
190 https://doi.org/10.1038/ki.1989.264
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/ki.1989.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438852
193 https://doi.org/10.1038/ki.1989.98
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/ki.1990.112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037653161
196 https://doi.org/10.1038/ki.1990.112
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/ki.1990.44 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008105625
199 https://doi.org/10.1038/ki.1990.44
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/ki.1990.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049358760
202 https://doi.org/10.1038/ki.1990.46
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/ki.1990.59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001035371
205 https://doi.org/10.1038/ki.1990.59
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1078928291 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1078946914 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1079003229 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1079025017 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1079160954 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1079306197 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1079353892 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1079414741 schema:CreativeWork
216 https://app.dimensions.ai/details/publication/pub.1079507400 schema:CreativeWork
217 https://app.dimensions.ai/details/publication/pub.1079519938 schema:CreativeWork
218 https://app.dimensions.ai/details/publication/pub.1079572465 schema:CreativeWork
219 https://app.dimensions.ai/details/publication/pub.1079588153 schema:CreativeWork
220 https://app.dimensions.ai/details/publication/pub.1079610032 schema:CreativeWork
221 https://app.dimensions.ai/details/publication/pub.1079646637 schema:CreativeWork
222 https://app.dimensions.ai/details/publication/pub.1079647844 schema:CreativeWork
223 https://doi.org/10.1016/0014-5793(88)80543-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040759424
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1016/0092-8674(88)90486-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038588184
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1016/0092-8674(90)90816-w schema:sameAs https://app.dimensions.ai/details/publication/pub.1031069718
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/s0065-2776(08)60846-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032470215
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1073/pnas.86.3.1056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042488821
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1084/jem.158.6.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013516845
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1152/ajprenal.1986.251.5.f765 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079511505
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1152/physrev.1990.70.2.427 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077283513
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1164/ajrccm/139.4.1010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013753601
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1172/jci112790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016276758
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1177/34.7.3458811 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011784733
244 rdf:type schema:CreativeWork
 




Preview window. Press ESC to close (or click here)


...