MHC class II, antigen presentation and tumor necrosis factor in renal tubular epithelial cells View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-02

AUTHORS

R P Wuthrich, L H Glimcher, M A Yui, A M Jevnikar, S E Dumas, V E Kelley

ABSTRACT

Proximal tubular (PT) epithelial cells express MHC class II (Ia) antigens in immunologically-mediated renal injury. To study the role of PT as accessory cells, we generated several murine PT-like epithelial cell lines by transformation with origin-defective SV40 DNA. These transformed cell lines display typical alkaline phosphatase and gamma-glutamyl-transpeptidase enzyme activity, proliferation to epidermal growth factor (EGF) and sodium-dependent glucose uptake. Clonal lines of transformed tubular cells from both normal C3H/FeJ and autoimmune MRL-lpr mice do not constitutively express Ia antigens or mRNA for class II. However, stimulation with recombinant interferon-gamma(rIFN-gamma) induces Ia mRNA and surface product in the cell lines. These Ia-positive cells can process and present hen egg-white lysozyme (HEL) to antigen-specific Iak-restricted T cell hybrids. Unstimulated tubular cells do not express detectable IL-1 alpha, IL-1 beta, TNA-alpha, or IL-6 mRNA. However, stimulation with IL-1 alpha or LPS induces TNF-alpha transcripts. We conclude that these cell lines have characteristics most consistent with a proximal tubular origin. They also bear characteristics of accessory cells such as processing and presentation of antigen and TNF-alpha gene expression. We speculate that PT have the capacity to participate in the pathogenesis of immune renal injury. More... »

PAGES

783-792

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1990.46

DOI

http://dx.doi.org/10.1038/ki.1990.46

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049358760

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2407890


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Download the RDF metadata as:  json-ld nt turtle xml License info

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Turtle is a human-readable linked data format.

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RDF/XML is a standard XML format for linked data.

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313 schema:name Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts.
314 rdf:type schema:Organization
 




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