Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1 View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-12

AUTHORS

D C Brennan, A M Jevnikar, F Takei, V E Reubin-Kelley

ABSTRACT

Mesangial cell (MC) proliferation is an early pathologic alteration characteristic of many forms of immune mediated glomerulonephritis. The intracapillary position, contractile capacity, and production of cytokines and other inflammatory molecules place MC in a pivotal position to initiate, mediate, and direct glomerular damage. We as well as others have noted increased levels of cytokines including IFN gamma, TNF, and IL-1 and the cell surface MHC class II and ICAM-1 molecules in the kidneys of mice with lupus nephritis. MHC class II and ICAM-1 molecules are central to the interaction of T cells with antigen presenting cells (APC). Since cytokines can increase both MHC class II and ICAM-1 molecules, we investigated whether mesangial cells could function as APC or accessory cells after cytokine stimulation. For these studies we established a permanent MC line through transformation with origin-deficient SV40 DNA. Surface expression of ICAM-1 was similar in untransformed MC as well as SV40 transformed MC from normal mice and in untransformed cells from mice with lupus nephritis. Basal expression of ICAM-1 was upregulated rapidly by IFN gamma, TNF, and IL-1. MHC class II expression could not be induced with TNF or IL-1 alone but required prolonged stimulation with IFN gamma. MC adhered and presented antigen to an antigen specific IaK restricted T cell hybridoma. Anti-ICAM-1 mAb decreased adhesion and antigen presentation of cytokine stimulated MC. By comparison, MHC class II mAb abrogated antigen presentation by MC bearing MHC class II but did not block adhesion.(ABSTRACT TRUNCATED AT 250 WORDS) More... »

PAGES

1039-1046

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1990.310

DOI

http://dx.doi.org/10.1038/ki.1990.310

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004520994

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/1981601


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigen-Presenting Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antigens, CD", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion Molecules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Transformation, Viral", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytokines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Mesangium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histocompatibility Antigens Class II", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Intercellular Adhesion Molecule-1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lupus Nephritis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred Strains", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Brigham and Women's Hospital", 
          "id": "https://www.grid.ac/institutes/grid.62560.37", 
          "name": [
            "Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital Boston, Massachusetts."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brennan", 
        "givenName": "D C", 
        "id": "sg:person.010045701052.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010045701052.63"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Jevnikar", 
        "givenName": "A M", 
        "id": "sg:person.01365524517.79", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365524517.79"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Takei", 
        "givenName": "F", 
        "id": "sg:person.01232113306.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232113306.50"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Reubin-Kelley", 
        "givenName": "V E", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.158.6.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013516845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0092-8674(75)90086-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013566584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(79)80866-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016613417"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1978.86", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021019251", 
          "https://doi.org/10.1038/ki.1978.86"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00490219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691111", 
          "https://doi.org/10.1007/bf00490219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf00490219", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022691111", 
          "https://doi.org/10.1007/bf00490219"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.21.7413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022874269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023438852", 
          "https://doi.org/10.1038/ki.1989.98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.1989.tb00016.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026561657"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci110304", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030661456"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.162.4.1264", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030702503"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/338512a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031423061", 
          "https://doi.org/10.1038/338512a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0090-1229(84)90022-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035181636"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.167.4.1323", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040130262"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.150.3.413", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041488154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.53", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042952205", 
          "https://doi.org/10.1038/ki.1988.53"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1984.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044282551", 
          "https://doi.org/10.1038/ki.1984.231"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077946024", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078403079", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078926894", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078928291", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1460-2075.1989.tb08437.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079051328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079067763", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079492233", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajpcell.1985.249.1.c48", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079496178"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079517317", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079646491", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647844", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079779147", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079807383", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081559689", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081677271", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082116283", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082120787", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-12", 
    "datePublishedReg": "1990-12-01", 
    "description": "Mesangial cell (MC) proliferation is an early pathologic alteration characteristic of many forms of immune mediated glomerulonephritis. The intracapillary position, contractile capacity, and production of cytokines and other inflammatory molecules place MC in a pivotal position to initiate, mediate, and direct glomerular damage. We as well as others have noted increased levels of cytokines including IFN gamma, TNF, and IL-1 and the cell surface MHC class II and ICAM-1 molecules in the kidneys of mice with lupus nephritis. MHC class II and ICAM-1 molecules are central to the interaction of T cells with antigen presenting cells (APC). Since cytokines can increase both MHC class II and ICAM-1 molecules, we investigated whether mesangial cells could function as APC or accessory cells after cytokine stimulation. For these studies we established a permanent MC line through transformation with origin-deficient SV40 DNA. Surface expression of ICAM-1 was similar in untransformed MC as well as SV40 transformed MC from normal mice and in untransformed cells from mice with lupus nephritis. Basal expression of ICAM-1 was upregulated rapidly by IFN gamma, TNF, and IL-1. MHC class II expression could not be induced with TNF or IL-1 alone but required prolonged stimulation with IFN gamma. MC adhered and presented antigen to an antigen specific IaK restricted T cell hybridoma. Anti-ICAM-1 mAb decreased adhesion and antigen presentation of cytokine stimulated MC. By comparison, MHC class II mAb abrogated antigen presentation by MC bearing MHC class II but did not block adhesion.(ABSTRACT TRUNCATED AT 250 WORDS)", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1990.310", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2369529", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2493196", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2436100", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "6", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1", 
    "pagination": "1039-1046", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "158b06dadec6ae62a8ea447ee19d11093bb16ae4c62c70c02b605b080b7961f2"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "1981601"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1990.310"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1004520994"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1990.310", 
      "https://app.dimensions.ai/details/publication/pub.1004520994"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:54", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000421.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v38/n6/abs/ki1990310a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.310'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.310'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.310'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.310'


 

This table displays all metadata directly associated to this object as RDF triples.

237 TRIPLES      21 PREDICATES      76 URIs      34 LITERALS      22 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1990.310 schema:about N2bd6ee2eb9314ad692cbf33fd785dd60
2 N3167e196b045498db351f7c8d6c72d27
3 N3c6fc80a4d184d67bd6e0beab39fa8c0
4 N5837a43539aa4d3f9979036f76fecafe
5 N6e3bf1971f1543e9a4c4fa47d8b52356
6 N80a0be7f72344074a100b0a2cc257cc6
7 N85ce471bb8744a258e70679da4b9860c
8 N8a61fa5a5e564bc2ad2a0ecf3815a73d
9 Na26a05ea6a204851bf58eca9f4f3b9ff
10 Nbc28b33e145b48048150c004e9a4d663
11 Nbdad735c866c4455adf7393557846beb
12 Ne225cf23bc2a4f7ab03e96e8cf698d9e
13 Nf54d98b549f645d0843d216952817f62
14 anzsrc-for:11
15 anzsrc-for:1107
16 schema:author Nbe7c19c288b141ff8a36a12fb485fff7
17 schema:citation sg:pub.10.1007/bf00490219
18 sg:pub.10.1038/338512a0
19 sg:pub.10.1038/ki.1978.86
20 sg:pub.10.1038/ki.1984.231
21 sg:pub.10.1038/ki.1988.53
22 sg:pub.10.1038/ki.1989.98
23 https://app.dimensions.ai/details/publication/pub.1077946024
24 https://app.dimensions.ai/details/publication/pub.1078403079
25 https://app.dimensions.ai/details/publication/pub.1078926894
26 https://app.dimensions.ai/details/publication/pub.1078928291
27 https://app.dimensions.ai/details/publication/pub.1079067763
28 https://app.dimensions.ai/details/publication/pub.1079492233
29 https://app.dimensions.ai/details/publication/pub.1079517317
30 https://app.dimensions.ai/details/publication/pub.1079646491
31 https://app.dimensions.ai/details/publication/pub.1079647844
32 https://app.dimensions.ai/details/publication/pub.1079779147
33 https://app.dimensions.ai/details/publication/pub.1079807383
34 https://app.dimensions.ai/details/publication/pub.1081559689
35 https://app.dimensions.ai/details/publication/pub.1081677271
36 https://app.dimensions.ai/details/publication/pub.1082116283
37 https://app.dimensions.ai/details/publication/pub.1082120787
38 https://doi.org/10.1002/j.1460-2075.1989.tb08437.x
39 https://doi.org/10.1016/0014-5793(79)80866-2
40 https://doi.org/10.1016/0022-1759(83)90303-4
41 https://doi.org/10.1016/0090-1229(84)90022-9
42 https://doi.org/10.1016/0092-8674(75)90086-0
43 https://doi.org/10.1073/pnas.84.21.7413
44 https://doi.org/10.1084/jem.150.3.413
45 https://doi.org/10.1084/jem.158.6.1836
46 https://doi.org/10.1084/jem.162.4.1264
47 https://doi.org/10.1084/jem.167.4.1323
48 https://doi.org/10.1111/j.1600-065x.1989.tb00016.x
49 https://doi.org/10.1152/ajpcell.1985.249.1.c48
50 https://doi.org/10.1172/jci110304
51 schema:datePublished 1990-12
52 schema:datePublishedReg 1990-12-01
53 schema:description Mesangial cell (MC) proliferation is an early pathologic alteration characteristic of many forms of immune mediated glomerulonephritis. The intracapillary position, contractile capacity, and production of cytokines and other inflammatory molecules place MC in a pivotal position to initiate, mediate, and direct glomerular damage. We as well as others have noted increased levels of cytokines including IFN gamma, TNF, and IL-1 and the cell surface MHC class II and ICAM-1 molecules in the kidneys of mice with lupus nephritis. MHC class II and ICAM-1 molecules are central to the interaction of T cells with antigen presenting cells (APC). Since cytokines can increase both MHC class II and ICAM-1 molecules, we investigated whether mesangial cells could function as APC or accessory cells after cytokine stimulation. For these studies we established a permanent MC line through transformation with origin-deficient SV40 DNA. Surface expression of ICAM-1 was similar in untransformed MC as well as SV40 transformed MC from normal mice and in untransformed cells from mice with lupus nephritis. Basal expression of ICAM-1 was upregulated rapidly by IFN gamma, TNF, and IL-1. MHC class II expression could not be induced with TNF or IL-1 alone but required prolonged stimulation with IFN gamma. MC adhered and presented antigen to an antigen specific IaK restricted T cell hybridoma. Anti-ICAM-1 mAb decreased adhesion and antigen presentation of cytokine stimulated MC. By comparison, MHC class II mAb abrogated antigen presentation by MC bearing MHC class II but did not block adhesion.(ABSTRACT TRUNCATED AT 250 WORDS)
54 schema:genre research_article
55 schema:inLanguage en
56 schema:isAccessibleForFree true
57 schema:isPartOf N4549a9efb1fb4fcb932aa5d8ec2cee06
58 Nb4e9806eb77d4c728cc8d4e7ccd6d2bd
59 sg:journal.1015319
60 schema:name Mesangial cell accessory functions: Mediation by intercellular adhesion molecule-1
61 schema:pagination 1039-1046
62 schema:productId N3029a76b3cbc449886bac827ffc8a895
63 N40bdc289623a42ae8f80c43243e814fb
64 N5dcf16f0e5ed464fbde4d83e24a40747
65 Na98e5adf74674633a0f8e1936c9ecbd9
66 Ne3b22caec26e442d847415f0d739e403
67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004520994
68 https://doi.org/10.1038/ki.1990.310
69 schema:sdDatePublished 2019-04-11T00:54
70 schema:sdLicense https://scigraph.springernature.com/explorer/license/
71 schema:sdPublisher N61272ec2664748f8a2e0d5da9f1aff33
72 schema:url http://www.nature.com/ki/journal/v38/n6/abs/ki1990310a.html
73 sgo:license sg:explorer/license/
74 sgo:sdDataset articles
75 rdf:type schema:ScholarlyArticle
76 N2bd6ee2eb9314ad692cbf33fd785dd60 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Lupus Nephritis
78 rdf:type schema:DefinedTerm
79 N3029a76b3cbc449886bac827ffc8a895 schema:name readcube_id
80 schema:value 158b06dadec6ae62a8ea447ee19d11093bb16ae4c62c70c02b605b080b7961f2
81 rdf:type schema:PropertyValue
82 N3167e196b045498db351f7c8d6c72d27 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
83 schema:name Cytokines
84 rdf:type schema:DefinedTerm
85 N32aefca08e184886a7f0ecdd55e68d1b rdf:first sg:person.01232113306.50
86 rdf:rest N6d849852981b420892a8ba2113f4fd5d
87 N3c6fc80a4d184d67bd6e0beab39fa8c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
88 schema:name Mice, Inbred Strains
89 rdf:type schema:DefinedTerm
90 N40bdc289623a42ae8f80c43243e814fb schema:name pubmed_id
91 schema:value 1981601
92 rdf:type schema:PropertyValue
93 N4549a9efb1fb4fcb932aa5d8ec2cee06 schema:volumeNumber 38
94 rdf:type schema:PublicationVolume
95 N5837a43539aa4d3f9979036f76fecafe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Histocompatibility Antigens Class II
97 rdf:type schema:DefinedTerm
98 N5dcf16f0e5ed464fbde4d83e24a40747 schema:name doi
99 schema:value 10.1038/ki.1990.310
100 rdf:type schema:PropertyValue
101 N61272ec2664748f8a2e0d5da9f1aff33 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N6d849852981b420892a8ba2113f4fd5d rdf:first N74ab57c4cbde485ca4a887c0ef422b14
104 rdf:rest rdf:nil
105 N6e3bf1971f1543e9a4c4fa47d8b52356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Mice
107 rdf:type schema:DefinedTerm
108 N74ab57c4cbde485ca4a887c0ef422b14 schema:familyName Reubin-Kelley
109 schema:givenName V E
110 rdf:type schema:Person
111 N80a0be7f72344074a100b0a2cc257cc6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Intercellular Adhesion Molecule-1
113 rdf:type schema:DefinedTerm
114 N85ce471bb8744a258e70679da4b9860c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Animals
116 rdf:type schema:DefinedTerm
117 N8a61fa5a5e564bc2ad2a0ecf3815a73d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Cells, Cultured
119 rdf:type schema:DefinedTerm
120 Na26a05ea6a204851bf58eca9f4f3b9ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Antigens, CD
122 rdf:type schema:DefinedTerm
123 Na98e5adf74674633a0f8e1936c9ecbd9 schema:name dimensions_id
124 schema:value pub.1004520994
125 rdf:type schema:PropertyValue
126 Nb4e9806eb77d4c728cc8d4e7ccd6d2bd schema:issueNumber 6
127 rdf:type schema:PublicationIssue
128 Nbc28b33e145b48048150c004e9a4d663 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Antigen-Presenting Cells
130 rdf:type schema:DefinedTerm
131 Nbd10ae64802543bcae7a16ef949477f0 rdf:first sg:person.01365524517.79
132 rdf:rest N32aefca08e184886a7f0ecdd55e68d1b
133 Nbdad735c866c4455adf7393557846beb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Cell Adhesion Molecules
135 rdf:type schema:DefinedTerm
136 Nbe7c19c288b141ff8a36a12fb485fff7 rdf:first sg:person.010045701052.63
137 rdf:rest Nbd10ae64802543bcae7a16ef949477f0
138 Ne225cf23bc2a4f7ab03e96e8cf698d9e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Cell Transformation, Viral
140 rdf:type schema:DefinedTerm
141 Ne3b22caec26e442d847415f0d739e403 schema:name nlm_unique_id
142 schema:value 0323470
143 rdf:type schema:PropertyValue
144 Nf54d98b549f645d0843d216952817f62 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Glomerular Mesangium
146 rdf:type schema:DefinedTerm
147 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
148 schema:name Medical and Health Sciences
149 rdf:type schema:DefinedTerm
150 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
151 schema:name Immunology
152 rdf:type schema:DefinedTerm
153 sg:grant.2369529 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.1990.310
154 rdf:type schema:MonetaryGrant
155 sg:grant.2436100 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.1990.310
156 rdf:type schema:MonetaryGrant
157 sg:grant.2493196 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.1990.310
158 rdf:type schema:MonetaryGrant
159 sg:journal.1015319 schema:issn 0085-2538
160 1523-1755
161 schema:name Kidney International
162 rdf:type schema:Periodical
163 sg:person.010045701052.63 schema:affiliation https://www.grid.ac/institutes/grid.62560.37
164 schema:familyName Brennan
165 schema:givenName D C
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010045701052.63
167 rdf:type schema:Person
168 sg:person.01232113306.50 schema:familyName Takei
169 schema:givenName F
170 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01232113306.50
171 rdf:type schema:Person
172 sg:person.01365524517.79 schema:familyName Jevnikar
173 schema:givenName A M
174 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365524517.79
175 rdf:type schema:Person
176 sg:pub.10.1007/bf00490219 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022691111
177 https://doi.org/10.1007/bf00490219
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/338512a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031423061
180 https://doi.org/10.1038/338512a0
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/ki.1978.86 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021019251
183 https://doi.org/10.1038/ki.1978.86
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/ki.1984.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044282551
186 https://doi.org/10.1038/ki.1984.231
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/ki.1988.53 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042952205
189 https://doi.org/10.1038/ki.1988.53
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/ki.1989.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438852
192 https://doi.org/10.1038/ki.1989.98
193 rdf:type schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1077946024 schema:CreativeWork
195 https://app.dimensions.ai/details/publication/pub.1078403079 schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1078926894 schema:CreativeWork
197 https://app.dimensions.ai/details/publication/pub.1078928291 schema:CreativeWork
198 https://app.dimensions.ai/details/publication/pub.1079067763 schema:CreativeWork
199 https://app.dimensions.ai/details/publication/pub.1079492233 schema:CreativeWork
200 https://app.dimensions.ai/details/publication/pub.1079517317 schema:CreativeWork
201 https://app.dimensions.ai/details/publication/pub.1079646491 schema:CreativeWork
202 https://app.dimensions.ai/details/publication/pub.1079647844 schema:CreativeWork
203 https://app.dimensions.ai/details/publication/pub.1079779147 schema:CreativeWork
204 https://app.dimensions.ai/details/publication/pub.1079807383 schema:CreativeWork
205 https://app.dimensions.ai/details/publication/pub.1081559689 schema:CreativeWork
206 https://app.dimensions.ai/details/publication/pub.1081677271 schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1082116283 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1082120787 schema:CreativeWork
209 https://doi.org/10.1002/j.1460-2075.1989.tb08437.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1079051328
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/0014-5793(79)80866-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016613417
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/0022-1759(83)90303-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705634
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/0090-1229(84)90022-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035181636
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/0092-8674(75)90086-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013566584
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1073/pnas.84.21.7413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022874269
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1084/jem.150.3.413 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041488154
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1084/jem.158.6.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013516845
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1084/jem.162.4.1264 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030702503
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1084/jem.167.4.1323 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040130262
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1111/j.1600-065x.1989.tb00016.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1026561657
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1152/ajpcell.1985.249.1.c48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079496178
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1172/jci110304 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030661456
234 rdf:type schema:CreativeWork
235 https://www.grid.ac/institutes/grid.62560.37 schema:alternateName Brigham and Women's Hospital
236 schema:name Laboratory of Immunogenetics and Transplantation, Brigham and Women's Hospital Boston, Massachusetts.
237 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...