Tumor necrosis factor induces contraction of mesangial cells and alters their cytoskeletons View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1990-11

AUTHORS

G Camussi, E Turello, C Tetta, F Bussolino, C Baglioni

ABSTRACT

Cultures of human mesangial cells (MC) were established from the renal cortex of surgical specimen. The characteristic spindle-shaped or stellate appearance of MC was altered after treatment with tumor necrosis factor (TNF). After two hours, the MC retracted and lost reciprocal contacts. Furthermore, this treatment altered the cytoskeletal organization of MC, since a peripheral band of actin and stress fibers disappeared while the streaks of vinculin at focal contacts decreased. These changes were reversible when the MC were cultured in fresh medium. After five minutes of treatment with platelet activating factor (PAF), changes similar to those induced by TNF were observed. Inhibitors of PAF synthesis, such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide, blocked changes induced by TNF, PAF receptor antagonists inhibited changes induced by PAF and also by TNF. These results and the finding that MC are stimulated to produce PAF by TNF suggest that PAF is a secondary mediator of the changes in cell shape and cytoskeletal organization induced by this cytokine. More... »

PAGES

795-802

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1990.273

DOI

http://dx.doi.org/10.1038/ki.1990.273

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1018884226

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/2266661


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cells, Cultured", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytoskeleton", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Glomerular Mesangium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "In Vitro Techniques", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Fluorescence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microscopy, Phase-Contrast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Platelet Activating Factor", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Necrosis Factor-alpha", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Naples Federico II", 
          "id": "https://www.grid.ac/institutes/grid.4691.a", 
          "name": [
            "Dipartimento di Biochimica e Biofisica, 1a Facolt\u00e0 di Medicina, Universit\u00e0 di Napoli, Italy."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Camussi", 
        "givenName": "G", 
        "id": "sg:person.0762164060.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762164060.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Turello", 
        "givenName": "E", 
        "id": "sg:person.01077246441.84", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077246441.84"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Tetta", 
        "givenName": "C", 
        "id": "sg:person.01027454041.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027454041.89"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bussolino", 
        "givenName": "F", 
        "id": "sg:person.0725020654.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725020654.74"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Baglioni", 
        "givenName": "C", 
        "id": "sg:person.0614171505.33", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614171505.33"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1139/o59-099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001206449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002328380", 
          "https://doi.org/10.1038/ki.1986.266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1749-6632.1982.tb25706.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003866200"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci109723", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004024877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/294691a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008330860", 
          "https://doi.org/10.1038/294691a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4889(88)90055-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008540839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0167-4889(88)90055-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008540839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90427-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010440619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-2999(85)90427-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010440619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.99.5.1696", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010802172"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.158.6.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013516845"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335726a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014372844", 
          "https://doi.org/10.1038/335726a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/335726a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014372844", 
          "https://doi.org/10.1038/335726a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014505261"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.90.1.84", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018032179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0014-5793(80)80375-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019577253"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm198702123160705", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022074048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(83)90049-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022529487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0024-3205(83)90049-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022529487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1989.98", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023438852", 
          "https://doi.org/10.1038/ki.1989.98"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.166.6.1836", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025622643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.160.1.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028494540"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1988.249", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031056523", 
          "https://doi.org/10.1038/ki.1988.249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci111309", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032571592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bi.52.070183.003255", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033743702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1987.138", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034425754", 
          "https://doi.org/10.1038/ki.1987.138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0162-3109(86)90046-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034520195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0162-3109(86)90046-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034520195"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.23", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034713692", 
          "https://doi.org/10.1038/ki.1986.23"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.166.5.1390", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037421959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1986.176", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040123179", 
          "https://doi.org/10.1038/ki.1986.176"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.169.6.1977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042806070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.168.4.1293", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044766917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci113880", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047289751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.171.3.913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047788112"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.76.9.4498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050098152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1432-1033.1989.tb14876.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053655170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3895437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062622090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078811238", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1987.253.6.f1283", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079413461"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079474869", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1985.249.2.f227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079497273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1985.249.4.f457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079499167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079511836", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1986.250.6.f1123", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079548476"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1986.251.1.f1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079549294"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079563221", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079566844", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079647190", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1096/fasebj.1.4.3308611", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079675225"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080019270", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajprenal.1985.248.2.f240", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080034381"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082093118", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083337661", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000399229", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1088678102"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1990-11", 
    "datePublishedReg": "1990-11-01", 
    "description": "Cultures of human mesangial cells (MC) were established from the renal cortex of surgical specimen. The characteristic spindle-shaped or stellate appearance of MC was altered after treatment with tumor necrosis factor (TNF). After two hours, the MC retracted and lost reciprocal contacts. Furthermore, this treatment altered the cytoskeletal organization of MC, since a peripheral band of actin and stress fibers disappeared while the streaks of vinculin at focal contacts decreased. These changes were reversible when the MC were cultured in fresh medium. After five minutes of treatment with platelet activating factor (PAF), changes similar to those induced by TNF were observed. Inhibitors of PAF synthesis, such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide, blocked changes induced by TNF, PAF receptor antagonists inhibited changes induced by PAF and also by TNF. These results and the finding that MC are stimulated to produce PAF by TNF suggest that PAF is a secondary mediator of the changes in cell shape and cytoskeletal organization induced by this cytokine.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1990.273", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2466790", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "38"
      }
    ], 
    "name": "Tumor necrosis factor induces contraction of mesangial cells and alters their cytoskeletons", 
    "pagination": "795-802", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "59fa57625fefb7615a17620ea7298e3387575a26a60e81211853ac0d3e539576"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "2266661"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1990.273"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1018884226"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1990.273", 
      "https://app.dimensions.ai/details/publication/pub.1018884226"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T21:24", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8687_00000424.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v38/n5/abs/ki1990273a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.273'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.273'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.273'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1990.273'


 

This table displays all metadata directly associated to this object as RDF triples.

284 TRIPLES      21 PREDICATES      89 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1990.273 schema:about N1f912f1504b24f838a510f160e32027b
2 N494e2745114345159b99e516b2571ef6
3 N558a0096d3964d9a8acf3e5d5641f0e1
4 N83cb7fbb3f73465ab7dbe34814ce2612
5 Nb9a17f2aee4a481d8b0bf098b022a7a1
6 Nc0ed9e89e3e14a9982c6ce26dfe87a14
7 Nc1217327c6494a1cada61933a8c87a08
8 Nc87ee36267874a51b4d73fc3ef3f958e
9 Ndaaf1a05511643e7a725dedb34b3d9f6
10 Nf1761e22cfae4233a346ac678a083297
11 anzsrc-for:06
12 anzsrc-for:0601
13 schema:author N1a17e64199fa4c74b5913a3ebb6d05c9
14 schema:citation sg:pub.10.1038/294691a0
15 sg:pub.10.1038/335726a0
16 sg:pub.10.1038/ki.1986.176
17 sg:pub.10.1038/ki.1986.23
18 sg:pub.10.1038/ki.1986.266
19 sg:pub.10.1038/ki.1987.138
20 sg:pub.10.1038/ki.1988.249
21 sg:pub.10.1038/ki.1989.98
22 https://app.dimensions.ai/details/publication/pub.1078811238
23 https://app.dimensions.ai/details/publication/pub.1079474869
24 https://app.dimensions.ai/details/publication/pub.1079511836
25 https://app.dimensions.ai/details/publication/pub.1079563221
26 https://app.dimensions.ai/details/publication/pub.1079566844
27 https://app.dimensions.ai/details/publication/pub.1079647190
28 https://app.dimensions.ai/details/publication/pub.1080019270
29 https://app.dimensions.ai/details/publication/pub.1082093118
30 https://app.dimensions.ai/details/publication/pub.1083337661
31 https://doi.org/10.1016/0014-2999(85)90427-3
32 https://doi.org/10.1016/0014-5793(80)80375-9
33 https://doi.org/10.1016/0024-3205(83)90049-8
34 https://doi.org/10.1016/0162-3109(86)90046-9
35 https://doi.org/10.1016/0167-4889(88)90055-9
36 https://doi.org/10.1056/nejm198702123160705
37 https://doi.org/10.1073/pnas.76.9.4498
38 https://doi.org/10.1083/jcb.90.1.84
39 https://doi.org/10.1083/jcb.99.5.1696
40 https://doi.org/10.1084/jem.158.6.1836
41 https://doi.org/10.1084/jem.160.1.286
42 https://doi.org/10.1084/jem.166.5.1390
43 https://doi.org/10.1084/jem.166.6.1836
44 https://doi.org/10.1084/jem.168.4.1293
45 https://doi.org/10.1084/jem.169.6.1977
46 https://doi.org/10.1084/jem.171.3.913
47 https://doi.org/10.1096/fasebj.1.4.3308611
48 https://doi.org/10.1111/j.1432-1033.1989.tb14876.x
49 https://doi.org/10.1111/j.1749-6632.1982.tb25706.x
50 https://doi.org/10.1126/science.3895437
51 https://doi.org/10.1139/o59-099
52 https://doi.org/10.1146/annurev.bi.52.070183.003255
53 https://doi.org/10.1152/ajprenal.1985.248.2.f240
54 https://doi.org/10.1152/ajprenal.1985.249.2.f227
55 https://doi.org/10.1152/ajprenal.1985.249.4.f457
56 https://doi.org/10.1152/ajprenal.1986.250.6.f1123
57 https://doi.org/10.1152/ajprenal.1986.251.1.f1
58 https://doi.org/10.1152/ajprenal.1987.253.6.f1283
59 https://doi.org/10.1159/000399229
60 https://doi.org/10.1172/jci109723
61 https://doi.org/10.1172/jci111309
62 https://doi.org/10.1172/jci113701
63 https://doi.org/10.1172/jci113880
64 schema:datePublished 1990-11
65 schema:datePublishedReg 1990-11-01
66 schema:description Cultures of human mesangial cells (MC) were established from the renal cortex of surgical specimen. The characteristic spindle-shaped or stellate appearance of MC was altered after treatment with tumor necrosis factor (TNF). After two hours, the MC retracted and lost reciprocal contacts. Furthermore, this treatment altered the cytoskeletal organization of MC, since a peripheral band of actin and stress fibers disappeared while the streaks of vinculin at focal contacts decreased. These changes were reversible when the MC were cultured in fresh medium. After five minutes of treatment with platelet activating factor (PAF), changes similar to those induced by TNF were observed. Inhibitors of PAF synthesis, such as plasma alpha 1-proteinase inhibitor and an anti-inflammatory peptide, blocked changes induced by TNF, PAF receptor antagonists inhibited changes induced by PAF and also by TNF. These results and the finding that MC are stimulated to produce PAF by TNF suggest that PAF is a secondary mediator of the changes in cell shape and cytoskeletal organization induced by this cytokine.
67 schema:genre research_article
68 schema:inLanguage en
69 schema:isAccessibleForFree true
70 schema:isPartOf Na4302eb27182491ba4e3bb6fe13b2207
71 Ne4e06b31fca14e28ae5141229b8d8455
72 sg:journal.1015319
73 schema:name Tumor necrosis factor induces contraction of mesangial cells and alters their cytoskeletons
74 schema:pagination 795-802
75 schema:productId N55274125bbab4759aa1163ce50990dbe
76 N86bc57bf7e2a40e693b41fdd057d5313
77 N98d99edc98ab46bf8ca30687a0610039
78 Nc35b121c105f4f81a7d6e06e202ace55
79 Ndfdae87cc50f49f989904e81e9195e1c
80 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018884226
81 https://doi.org/10.1038/ki.1990.273
82 schema:sdDatePublished 2019-04-10T21:24
83 schema:sdLicense https://scigraph.springernature.com/explorer/license/
84 schema:sdPublisher N9727c184fa8c4cca96adf727b3c98fee
85 schema:url http://www.nature.com/ki/journal/v38/n5/abs/ki1990273a.html
86 sgo:license sg:explorer/license/
87 sgo:sdDataset articles
88 rdf:type schema:ScholarlyArticle
89 N10a6b71e261c45bbb04098db0bc52e7a rdf:first sg:person.01027454041.89
90 rdf:rest N1b3eb2ef3d1e4422b8d58d7c3cbc271e
91 N1a17e64199fa4c74b5913a3ebb6d05c9 rdf:first sg:person.0762164060.11
92 rdf:rest N5101fbedf67846539e473a77766f496c
93 N1b3eb2ef3d1e4422b8d58d7c3cbc271e rdf:first sg:person.0725020654.74
94 rdf:rest Nf5667f94035e4e89826c6e1a5c069a24
95 N1f912f1504b24f838a510f160e32027b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Platelet Activating Factor
97 rdf:type schema:DefinedTerm
98 N494e2745114345159b99e516b2571ef6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Tumor Necrosis Factor-alpha
100 rdf:type schema:DefinedTerm
101 N5101fbedf67846539e473a77766f496c rdf:first sg:person.01077246441.84
102 rdf:rest N10a6b71e261c45bbb04098db0bc52e7a
103 N55274125bbab4759aa1163ce50990dbe schema:name pubmed_id
104 schema:value 2266661
105 rdf:type schema:PropertyValue
106 N558a0096d3964d9a8acf3e5d5641f0e1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Time Factors
108 rdf:type schema:DefinedTerm
109 N83cb7fbb3f73465ab7dbe34814ce2612 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Microscopy, Fluorescence
111 rdf:type schema:DefinedTerm
112 N86bc57bf7e2a40e693b41fdd057d5313 schema:name dimensions_id
113 schema:value pub.1018884226
114 rdf:type schema:PropertyValue
115 N9727c184fa8c4cca96adf727b3c98fee schema:name Springer Nature - SN SciGraph project
116 rdf:type schema:Organization
117 N98d99edc98ab46bf8ca30687a0610039 schema:name doi
118 schema:value 10.1038/ki.1990.273
119 rdf:type schema:PropertyValue
120 Na4302eb27182491ba4e3bb6fe13b2207 schema:volumeNumber 38
121 rdf:type schema:PublicationVolume
122 Nb9a17f2aee4a481d8b0bf098b022a7a1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Glomerular Mesangium
124 rdf:type schema:DefinedTerm
125 Nc0ed9e89e3e14a9982c6ce26dfe87a14 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Cells, Cultured
127 rdf:type schema:DefinedTerm
128 Nc1217327c6494a1cada61933a8c87a08 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cytoskeleton
130 rdf:type schema:DefinedTerm
131 Nc35b121c105f4f81a7d6e06e202ace55 schema:name readcube_id
132 schema:value 59fa57625fefb7615a17620ea7298e3387575a26a60e81211853ac0d3e539576
133 rdf:type schema:PropertyValue
134 Nc87ee36267874a51b4d73fc3ef3f958e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Humans
136 rdf:type schema:DefinedTerm
137 Ndaaf1a05511643e7a725dedb34b3d9f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name In Vitro Techniques
139 rdf:type schema:DefinedTerm
140 Ndfdae87cc50f49f989904e81e9195e1c schema:name nlm_unique_id
141 schema:value 0323470
142 rdf:type schema:PropertyValue
143 Ne4e06b31fca14e28ae5141229b8d8455 schema:issueNumber 5
144 rdf:type schema:PublicationIssue
145 Nf1761e22cfae4233a346ac678a083297 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Microscopy, Phase-Contrast
147 rdf:type schema:DefinedTerm
148 Nf5667f94035e4e89826c6e1a5c069a24 rdf:first sg:person.0614171505.33
149 rdf:rest rdf:nil
150 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
151 schema:name Biological Sciences
152 rdf:type schema:DefinedTerm
153 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
154 schema:name Biochemistry and Cell Biology
155 rdf:type schema:DefinedTerm
156 sg:grant.2466790 http://pending.schema.org/fundedItem sg:pub.10.1038/ki.1990.273
157 rdf:type schema:MonetaryGrant
158 sg:journal.1015319 schema:issn 0085-2538
159 1523-1755
160 schema:name Kidney International
161 rdf:type schema:Periodical
162 sg:person.01027454041.89 schema:familyName Tetta
163 schema:givenName C
164 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027454041.89
165 rdf:type schema:Person
166 sg:person.01077246441.84 schema:familyName Turello
167 schema:givenName E
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01077246441.84
169 rdf:type schema:Person
170 sg:person.0614171505.33 schema:familyName Baglioni
171 schema:givenName C
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0614171505.33
173 rdf:type schema:Person
174 sg:person.0725020654.74 schema:familyName Bussolino
175 schema:givenName F
176 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725020654.74
177 rdf:type schema:Person
178 sg:person.0762164060.11 schema:affiliation https://www.grid.ac/institutes/grid.4691.a
179 schema:familyName Camussi
180 schema:givenName G
181 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762164060.11
182 rdf:type schema:Person
183 sg:pub.10.1038/294691a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008330860
184 https://doi.org/10.1038/294691a0
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/335726a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014372844
187 https://doi.org/10.1038/335726a0
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/ki.1986.176 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040123179
190 https://doi.org/10.1038/ki.1986.176
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/ki.1986.23 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034713692
193 https://doi.org/10.1038/ki.1986.23
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/ki.1986.266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002328380
196 https://doi.org/10.1038/ki.1986.266
197 rdf:type schema:CreativeWork
198 sg:pub.10.1038/ki.1987.138 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034425754
199 https://doi.org/10.1038/ki.1987.138
200 rdf:type schema:CreativeWork
201 sg:pub.10.1038/ki.1988.249 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031056523
202 https://doi.org/10.1038/ki.1988.249
203 rdf:type schema:CreativeWork
204 sg:pub.10.1038/ki.1989.98 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023438852
205 https://doi.org/10.1038/ki.1989.98
206 rdf:type schema:CreativeWork
207 https://app.dimensions.ai/details/publication/pub.1078811238 schema:CreativeWork
208 https://app.dimensions.ai/details/publication/pub.1079474869 schema:CreativeWork
209 https://app.dimensions.ai/details/publication/pub.1079511836 schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1079563221 schema:CreativeWork
211 https://app.dimensions.ai/details/publication/pub.1079566844 schema:CreativeWork
212 https://app.dimensions.ai/details/publication/pub.1079647190 schema:CreativeWork
213 https://app.dimensions.ai/details/publication/pub.1080019270 schema:CreativeWork
214 https://app.dimensions.ai/details/publication/pub.1082093118 schema:CreativeWork
215 https://app.dimensions.ai/details/publication/pub.1083337661 schema:CreativeWork
216 https://doi.org/10.1016/0014-2999(85)90427-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010440619
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1016/0014-5793(80)80375-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019577253
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1016/0024-3205(83)90049-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022529487
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1016/0162-3109(86)90046-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034520195
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1016/0167-4889(88)90055-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008540839
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1056/nejm198702123160705 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022074048
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1073/pnas.76.9.4498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050098152
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1083/jcb.90.1.84 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018032179
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1083/jcb.99.5.1696 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010802172
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1084/jem.158.6.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013516845
235 rdf:type schema:CreativeWork
236 https://doi.org/10.1084/jem.160.1.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028494540
237 rdf:type schema:CreativeWork
238 https://doi.org/10.1084/jem.166.5.1390 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037421959
239 rdf:type schema:CreativeWork
240 https://doi.org/10.1084/jem.166.6.1836 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025622643
241 rdf:type schema:CreativeWork
242 https://doi.org/10.1084/jem.168.4.1293 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044766917
243 rdf:type schema:CreativeWork
244 https://doi.org/10.1084/jem.169.6.1977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042806070
245 rdf:type schema:CreativeWork
246 https://doi.org/10.1084/jem.171.3.913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047788112
247 rdf:type schema:CreativeWork
248 https://doi.org/10.1096/fasebj.1.4.3308611 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079675225
249 rdf:type schema:CreativeWork
250 https://doi.org/10.1111/j.1432-1033.1989.tb14876.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1053655170
251 rdf:type schema:CreativeWork
252 https://doi.org/10.1111/j.1749-6632.1982.tb25706.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003866200
253 rdf:type schema:CreativeWork
254 https://doi.org/10.1126/science.3895437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062622090
255 rdf:type schema:CreativeWork
256 https://doi.org/10.1139/o59-099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001206449
257 rdf:type schema:CreativeWork
258 https://doi.org/10.1146/annurev.bi.52.070183.003255 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033743702
259 rdf:type schema:CreativeWork
260 https://doi.org/10.1152/ajprenal.1985.248.2.f240 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080034381
261 rdf:type schema:CreativeWork
262 https://doi.org/10.1152/ajprenal.1985.249.2.f227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079497273
263 rdf:type schema:CreativeWork
264 https://doi.org/10.1152/ajprenal.1985.249.4.f457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079499167
265 rdf:type schema:CreativeWork
266 https://doi.org/10.1152/ajprenal.1986.250.6.f1123 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079548476
267 rdf:type schema:CreativeWork
268 https://doi.org/10.1152/ajprenal.1986.251.1.f1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079549294
269 rdf:type schema:CreativeWork
270 https://doi.org/10.1152/ajprenal.1987.253.6.f1283 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079413461
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1159/000399229 schema:sameAs https://app.dimensions.ai/details/publication/pub.1088678102
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1172/jci109723 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004024877
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1172/jci111309 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032571592
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1172/jci113701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014505261
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1172/jci113880 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047289751
281 rdf:type schema:CreativeWork
282 https://www.grid.ac/institutes/grid.4691.a schema:alternateName University of Naples Federico II
283 schema:name Dipartimento di Biochimica e Biofisica, 1a Facoltà di Medicina, Università di Napoli, Italy.
284 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...