Amelioration of experimental glomerulonephritis by dietary protein restriction View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1983-11

AUTHORS

Joel Neugarten, Helen D. Feiner, Robert G. Schacht, David S. Baldwin

ABSTRACT

We have examined the effects of various levels of dietary protein intake on the course of nephrotoxic serum nephritis in the rat by feeding low (4.6% casein), standard (23% casein), and high (57.5% casein) protein diets which were identical in calorie, mineral, and electrolyte content. Nephritic rats on a high protein diet manifested heavy proteinuria, hypoalbuminemia, hypercholesterolemia, azotemia, and elevated serum creatinine levels. In those subjected to dietary protein restriction, proteinuria remitted and azotemia did not develop. While mesangial widening, interstitial abnormalities, and segmental proliferation and sclerosis of glomeruli occurred regularly in nephritic rats fed high protein diets, histologic abnormalities were virtually absent in those on low protein intake. Animals on a standard protein intake manifested histologic and clinical features intermediate in severity. We conclude that the renal functional and histologic consequences of nephrotoxic serum nephritis can be averted by dietary protein restriction. More... »

PAGES

595-601

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1983.199

DOI

http://dx.doi.org/10.1038/ki.1983.199

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049631355

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/6663981


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