Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

1977-07

AUTHORS

Silvia Azar, Mary Ann Johnson, Bruce Hertel, Louis Tobian

ABSTRACT

Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis. To study the effects of hypertension on a kidney with nephrosclerosis, single-nephron dynamics were determined in rats with one kidney "post-salt" hypertension with nephrosclerosis and in one and two kidney normotensive controls. Hypertension was induced by feeding weanling rats an 8% sodium chloride diet for nine and one half weeks, with a unilateral nephrectomy performed during the fourth week. Thereafter, regular chow was fed, but hypertension persisted. In the rats with hypertension, extensive nephrosclerosis was found, glomerular lesions predominating over arteriolar ones. The sum of afferent and efferent arteriolar resistances (RTA) ( 1010 dynesseccm-5) was decreased in surviving nephrons from hypertensive kidneys with nephrosclerosis and not increased as expected in hypertension. Hypertensive RTA averaged 1.07 0.08, while one and two kidney normotensive rats averaged 1.72 0.13 and 2.77 0.33, respectively. Because resistances were decreased, hypertensive rats had significantly higher glomerular blood flow (GBF) (1324 82 nl/min), and filtration rate (SNGFR) (162 13 nl/min), than the one-kidney normotensive rats: GBF, 583 41; SNGFR, 90 5. Two-kidney normotensive rats were even lower: GBF, 357 55; SNGFR, 60 6. Filtration fraction declined from 0.35 0.03 in two-kidney normotensive rats to 0.25 0.01 in hypertensive rats. The adaptive increase of SNGFR in uninephrectomized normotensive rats results mainly from increased GBF, plus a small increase in transcapillary hydraulic pressure difference (P); in rats having hypertension with nephrosclerosis, a very high P combines with increased flow to increase SNGFR greatly. Reduction of afferent and efferent arteriolar resistances is pivotal in the adaptive response. Greatly increased glomerular capillary pressure may be the pathophysiologic basis for the predominance of glomerular lesions in this model for hypertension. More... »

PAGES

28-40

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ki.1977.76

DOI

http://dx.doi.org/10.1038/ki.1977.76

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048455888

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/894914


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Blood Flow Velocity", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hemodynamics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension, Renal", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Kidney", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nephrosclerosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Rats", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sodium Chloride", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Resistance", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Divisions of Hypertension and Nephrology, Department of Internal Medicine, and Department of Laboratory Medicine and Pathology, University of Minnesota Hospital, Minneapolis, Minnesota"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Azar", 
        "givenName": "Silvia", 
        "id": "sg:person.014615574774.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014615574774.23"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Johnson", 
        "givenName": "Mary Ann", 
        "id": "sg:person.01254662521.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254662521.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Minnesota", 
          "id": "https://www.grid.ac/institutes/grid.17635.36", 
          "name": [
            "Divisions of Hypertension and Nephrology, Department of Internal Medicine, and Department of Laboratory Medicine and Pathology, University of Minnesota Hospital, Minneapolis, Minnesota"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hertel", 
        "givenName": "Bruce", 
        "type": "Person"
      }, 
      {
        "familyName": "Tobian", 
        "givenName": "Louis", 
        "id": "sg:person.0766714421.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766714421.01"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1084/jem.123.5.829", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000739920"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(54)91821-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003954855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(54)91821-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003954855"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci107857", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010423723"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1941.02820280014004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011430313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.36.2.286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013703546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1972.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016436201", 
          "https://doi.org/10.1038/ki.1972.66"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci101257", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019557368"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.1974.72", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024534007", 
          "https://doi.org/10.1038/ki.1974.72"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-70-17028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025532713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3181/00379727-70-17028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025532713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci105772", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037114834"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.31.1.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037432866"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci107934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041075524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1969.tb03287.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043304839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1969.tb03287.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043304839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci106667", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046365137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci107324", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046703295"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci106118", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048058888"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.115.6.1173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048126617"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cvr/6.5.569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059488625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.res.36.6.162", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063340293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075273425", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075705698", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076750128", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1974.227.3.556", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080329580"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1974.227.5.1045", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080347386"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1972.223.5.1178", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080504803"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1972.223.5.1184", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080504804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080506084", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080521212", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1972.223.4.741", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080792010"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1972.223.4.975", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080792034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1971.221.5.1521", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1080824250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplegacy.1970.219.2.299", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1081086448"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081334169", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081523757", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "1977-07", 
    "datePublishedReg": "1977-07-01", 
    "description": "Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis. To study the effects of hypertension on a kidney with nephrosclerosis, single-nephron dynamics were determined in rats with one kidney \"post-salt\" hypertension with nephrosclerosis and in one and two kidney normotensive controls. Hypertension was induced by feeding weanling rats an 8% sodium chloride diet for nine and one half weeks, with a unilateral nephrectomy performed during the fourth week. Thereafter, regular chow was fed, but hypertension persisted. In the rats with hypertension, extensive nephrosclerosis was found, glomerular lesions predominating over arteriolar ones. The sum of afferent and efferent arteriolar resistances (RTA) ( 1010 dynesseccm-5) was decreased in surviving nephrons from hypertensive kidneys with nephrosclerosis and not increased as expected in hypertension. Hypertensive RTA averaged 1.07 0.08, while one and two kidney normotensive rats averaged 1.72 0.13 and 2.77 0.33, respectively. Because resistances were decreased, hypertensive rats had significantly higher glomerular blood flow (GBF) (1324 82 nl/min), and filtration rate (SNGFR) (162 13 nl/min), than the one-kidney normotensive rats: GBF, 583 41; SNGFR, 90 5. Two-kidney normotensive rats were even lower: GBF, 357 55; SNGFR, 60 6. Filtration fraction declined from 0.35 0.03 in two-kidney normotensive rats to 0.25 0.01 in hypertensive rats. The adaptive increase of SNGFR in uninephrectomized normotensive rats results mainly from increased GBF, plus a small increase in transcapillary hydraulic pressure difference (P); in rats having hypertension with nephrosclerosis, a very high P combines with increased flow to increase SNGFR greatly. Reduction of afferent and efferent arteriolar resistances is pivotal in the adaptive response. Greatly increased glomerular capillary pressure may be the pathophysiologic basis for the predominance of glomerular lesions in this model for hypertension.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/ki.1977.76", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isPartOf": [
      {
        "id": "sg:journal.1015319", 
        "issn": [
          "0085-2538", 
          "1523-1755"
        ], 
        "name": "Kidney International", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "12"
      }
    ], 
    "name": "Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis", 
    "pagination": "28-40", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e6d5bd567d69b2844d8f8e7f135239fc6ebb741befb34218a484acf7f190b73b"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "894914"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0323470"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/ki.1977.76"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048455888"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/ki.1977.76", 
      "https://app.dimensions.ai/details/publication/pub.1048455888"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T00:55", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8697_00000426.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/ki/journal/v12/n1/abs/ki197776a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ki.1977.76'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ki.1977.76'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ki.1977.76'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ki.1977.76'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      21 PREDICATES      73 URIs      31 LITERALS      19 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/ki.1977.76 schema:about N0aa3b8643e2b447f96b5b6779ad47ac9
2 N3b9bad1d5dcb4ecb9c30f536ffbf2121
3 N54d6eb6bbbea4a5db2c120945ee076f2
4 N56517afc89674db8a9b56d0e3b517add
5 N5fccdd47ec0449c58247f12a04ae7ca5
6 N84060e4a9ec741b39d94e3ccb3d27809
7 N8f340bf1a6ff4c9ead7ba8f661b830bb
8 N9ff579e4b56649658b9c8c76d708d347
9 Nae46124dd1e045ea82350fc6d67850c5
10 Ndf673fc27f4b40b0a1bbf904f54c70f2
11 anzsrc-for:11
12 anzsrc-for:1103
13 schema:author N5d5bc38a7e3a48c28c59092ba1f6f55c
14 schema:citation sg:pub.10.1038/ki.1972.66
15 sg:pub.10.1038/ki.1974.72
16 https://app.dimensions.ai/details/publication/pub.1075273425
17 https://app.dimensions.ai/details/publication/pub.1075705698
18 https://app.dimensions.ai/details/publication/pub.1076750128
19 https://app.dimensions.ai/details/publication/pub.1080506084
20 https://app.dimensions.ai/details/publication/pub.1080521212
21 https://app.dimensions.ai/details/publication/pub.1081334169
22 https://app.dimensions.ai/details/publication/pub.1081523757
23 https://doi.org/10.1001/jama.1941.02820280014004
24 https://doi.org/10.1016/s0140-6736(54)91821-8
25 https://doi.org/10.1084/jem.115.6.1173
26 https://doi.org/10.1084/jem.123.5.829
27 https://doi.org/10.1093/cvr/6.5.569
28 https://doi.org/10.1111/j.1699-0463.1969.tb03287.x
29 https://doi.org/10.1152/ajplegacy.1970.219.2.299
30 https://doi.org/10.1152/ajplegacy.1971.221.5.1521
31 https://doi.org/10.1152/ajplegacy.1972.223.4.741
32 https://doi.org/10.1152/ajplegacy.1972.223.4.975
33 https://doi.org/10.1152/ajplegacy.1972.223.5.1178
34 https://doi.org/10.1152/ajplegacy.1972.223.5.1184
35 https://doi.org/10.1152/ajplegacy.1974.227.3.556
36 https://doi.org/10.1152/ajplegacy.1974.227.5.1045
37 https://doi.org/10.1161/01.res.31.1.1
38 https://doi.org/10.1161/01.res.36.2.286
39 https://doi.org/10.1161/01.res.36.6.162
40 https://doi.org/10.1172/jci101257
41 https://doi.org/10.1172/jci105772
42 https://doi.org/10.1172/jci106118
43 https://doi.org/10.1172/jci106667
44 https://doi.org/10.1172/jci107324
45 https://doi.org/10.1172/jci107857
46 https://doi.org/10.1172/jci107934
47 https://doi.org/10.3181/00379727-70-17028
48 schema:datePublished 1977-07
49 schema:datePublishedReg 1977-07-01
50 schema:description Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis. To study the effects of hypertension on a kidney with nephrosclerosis, single-nephron dynamics were determined in rats with one kidney "post-salt" hypertension with nephrosclerosis and in one and two kidney normotensive controls. Hypertension was induced by feeding weanling rats an 8% sodium chloride diet for nine and one half weeks, with a unilateral nephrectomy performed during the fourth week. Thereafter, regular chow was fed, but hypertension persisted. In the rats with hypertension, extensive nephrosclerosis was found, glomerular lesions predominating over arteriolar ones. The sum of afferent and efferent arteriolar resistances (RTA) ( 1010 dynesseccm-5) was decreased in surviving nephrons from hypertensive kidneys with nephrosclerosis and not increased as expected in hypertension. Hypertensive RTA averaged 1.07 0.08, while one and two kidney normotensive rats averaged 1.72 0.13 and 2.77 0.33, respectively. Because resistances were decreased, hypertensive rats had significantly higher glomerular blood flow (GBF) (1324 82 nl/min), and filtration rate (SNGFR) (162 13 nl/min), than the one-kidney normotensive rats: GBF, 583 41; SNGFR, 90 5. Two-kidney normotensive rats were even lower: GBF, 357 55; SNGFR, 60 6. Filtration fraction declined from 0.35 0.03 in two-kidney normotensive rats to 0.25 0.01 in hypertensive rats. The adaptive increase of SNGFR in uninephrectomized normotensive rats results mainly from increased GBF, plus a small increase in transcapillary hydraulic pressure difference (P); in rats having hypertension with nephrosclerosis, a very high P combines with increased flow to increase SNGFR greatly. Reduction of afferent and efferent arteriolar resistances is pivotal in the adaptive response. Greatly increased glomerular capillary pressure may be the pathophysiologic basis for the predominance of glomerular lesions in this model for hypertension.
51 schema:genre research_article
52 schema:inLanguage en
53 schema:isAccessibleForFree true
54 schema:isPartOf N4fa78652ddac4020b09498ec931244a5
55 Ne26aee9cfc494dd6bcc57816eb6cbe5d
56 sg:journal.1015319
57 schema:name Single-nephron pressures, flows, and resistances in hypertensive kidneys with nephrosclerosis
58 schema:pagination 28-40
59 schema:productId N22739fae3475498cb16fc796d23e0603
60 N413b197f298848fb90bbc2d7291b846f
61 N5ddfa8290e424d97a5578424a62926ca
62 Nbe99902be61943709190ad46249b9ebf
63 Nd0127325fc4340f88e14f1c36962833c
64 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048455888
65 https://doi.org/10.1038/ki.1977.76
66 schema:sdDatePublished 2019-04-11T00:55
67 schema:sdLicense https://scigraph.springernature.com/explorer/license/
68 schema:sdPublisher Nb66ab161142c4f5aa36c1cf221767671
69 schema:url http://www.nature.com/ki/journal/v12/n1/abs/ki197776a.html
70 sgo:license sg:explorer/license/
71 sgo:sdDataset articles
72 rdf:type schema:ScholarlyArticle
73 N05d6f921c05145c685adbcd6c0e558d7 rdf:first Nd57c700dd44b4b7c84ce70dd2c88f6e2
74 rdf:rest N976c43f3572840d7acd08687ee7d5adf
75 N0aa3b8643e2b447f96b5b6779ad47ac9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
76 schema:name Animals
77 rdf:type schema:DefinedTerm
78 N22739fae3475498cb16fc796d23e0603 schema:name pubmed_id
79 schema:value 894914
80 rdf:type schema:PropertyValue
81 N3b9bad1d5dcb4ecb9c30f536ffbf2121 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Hypertension, Renal
83 rdf:type schema:DefinedTerm
84 N413b197f298848fb90bbc2d7291b846f schema:name doi
85 schema:value 10.1038/ki.1977.76
86 rdf:type schema:PropertyValue
87 N4fa78652ddac4020b09498ec931244a5 schema:volumeNumber 12
88 rdf:type schema:PublicationVolume
89 N54d6eb6bbbea4a5db2c120945ee076f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Sodium Chloride
91 rdf:type schema:DefinedTerm
92 N56517afc89674db8a9b56d0e3b517add schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Hypertension
94 rdf:type schema:DefinedTerm
95 N5d5bc38a7e3a48c28c59092ba1f6f55c rdf:first sg:person.014615574774.23
96 rdf:rest Nc1f6b7d3783246f8b000f3c5dd997e1b
97 N5ddfa8290e424d97a5578424a62926ca schema:name dimensions_id
98 schema:value pub.1048455888
99 rdf:type schema:PropertyValue
100 N5fccdd47ec0449c58247f12a04ae7ca5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Vascular Resistance
102 rdf:type schema:DefinedTerm
103 N84060e4a9ec741b39d94e3ccb3d27809 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Nephrosclerosis
105 rdf:type schema:DefinedTerm
106 N8f340bf1a6ff4c9ead7ba8f661b830bb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Hemodynamics
108 rdf:type schema:DefinedTerm
109 N976c43f3572840d7acd08687ee7d5adf rdf:first sg:person.0766714421.01
110 rdf:rest rdf:nil
111 N9ff579e4b56649658b9c8c76d708d347 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Kidney
113 rdf:type schema:DefinedTerm
114 Nae46124dd1e045ea82350fc6d67850c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Blood Flow Velocity
116 rdf:type schema:DefinedTerm
117 Nb66ab161142c4f5aa36c1cf221767671 schema:name Springer Nature - SN SciGraph project
118 rdf:type schema:Organization
119 Nbe99902be61943709190ad46249b9ebf schema:name readcube_id
120 schema:value e6d5bd567d69b2844d8f8e7f135239fc6ebb741befb34218a484acf7f190b73b
121 rdf:type schema:PropertyValue
122 Nc1f6b7d3783246f8b000f3c5dd997e1b rdf:first sg:person.01254662521.37
123 rdf:rest N05d6f921c05145c685adbcd6c0e558d7
124 Nd0127325fc4340f88e14f1c36962833c schema:name nlm_unique_id
125 schema:value 0323470
126 rdf:type schema:PropertyValue
127 Nd57c700dd44b4b7c84ce70dd2c88f6e2 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
128 schema:familyName Hertel
129 schema:givenName Bruce
130 rdf:type schema:Person
131 Ndf673fc27f4b40b0a1bbf904f54c70f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Rats
133 rdf:type schema:DefinedTerm
134 Ne26aee9cfc494dd6bcc57816eb6cbe5d schema:issueNumber 1
135 rdf:type schema:PublicationIssue
136 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
137 schema:name Medical and Health Sciences
138 rdf:type schema:DefinedTerm
139 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
140 schema:name Clinical Sciences
141 rdf:type schema:DefinedTerm
142 sg:journal.1015319 schema:issn 0085-2538
143 1523-1755
144 schema:name Kidney International
145 rdf:type schema:Periodical
146 sg:person.01254662521.37 schema:familyName Johnson
147 schema:givenName Mary Ann
148 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01254662521.37
149 rdf:type schema:Person
150 sg:person.014615574774.23 schema:affiliation https://www.grid.ac/institutes/grid.17635.36
151 schema:familyName Azar
152 schema:givenName Silvia
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014615574774.23
154 rdf:type schema:Person
155 sg:person.0766714421.01 schema:familyName Tobian
156 schema:givenName Louis
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0766714421.01
158 rdf:type schema:Person
159 sg:pub.10.1038/ki.1972.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016436201
160 https://doi.org/10.1038/ki.1972.66
161 rdf:type schema:CreativeWork
162 sg:pub.10.1038/ki.1974.72 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024534007
163 https://doi.org/10.1038/ki.1974.72
164 rdf:type schema:CreativeWork
165 https://app.dimensions.ai/details/publication/pub.1075273425 schema:CreativeWork
166 https://app.dimensions.ai/details/publication/pub.1075705698 schema:CreativeWork
167 https://app.dimensions.ai/details/publication/pub.1076750128 schema:CreativeWork
168 https://app.dimensions.ai/details/publication/pub.1080506084 schema:CreativeWork
169 https://app.dimensions.ai/details/publication/pub.1080521212 schema:CreativeWork
170 https://app.dimensions.ai/details/publication/pub.1081334169 schema:CreativeWork
171 https://app.dimensions.ai/details/publication/pub.1081523757 schema:CreativeWork
172 https://doi.org/10.1001/jama.1941.02820280014004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011430313
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s0140-6736(54)91821-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003954855
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1084/jem.115.6.1173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048126617
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1084/jem.123.5.829 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000739920
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1093/cvr/6.5.569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059488625
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1111/j.1699-0463.1969.tb03287.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043304839
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1152/ajplegacy.1970.219.2.299 schema:sameAs https://app.dimensions.ai/details/publication/pub.1081086448
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1152/ajplegacy.1971.221.5.1521 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080824250
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1152/ajplegacy.1972.223.4.741 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080792010
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1152/ajplegacy.1972.223.4.975 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080792034
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1152/ajplegacy.1972.223.5.1178 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080504803
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1152/ajplegacy.1972.223.5.1184 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080504804
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1152/ajplegacy.1974.227.3.556 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080329580
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1152/ajplegacy.1974.227.5.1045 schema:sameAs https://app.dimensions.ai/details/publication/pub.1080347386
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1161/01.res.31.1.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037432866
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1161/01.res.36.2.286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013703546
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1161/01.res.36.6.162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063340293
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1172/jci101257 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019557368
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1172/jci105772 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037114834
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1172/jci106118 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048058888
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1172/jci106667 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046365137
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1172/jci107324 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046703295
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1172/jci107857 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010423723
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1172/jci107934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041075524
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3181/00379727-70-17028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025532713
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.17635.36 schema:alternateName University of Minnesota
223 schema:name Divisions of Hypertension and Nephrology, Department of Internal Medicine, and Department of Laboratory Medicine and Pathology, University of Minnesota Hospital, Minneapolis, Minnesota
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...