A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-07

AUTHORS

Leonie C Jacobs, Merel A Hamer, David A Gunn, Joris Deelen, Jaspal S Lall, Diana van Heemst, Hae-Won Uh, Albert Hofman, André G Uitterlinden, Christopher E M Griffiths, Marian Beekman, P Eline Slagboom, Manfred Kayser, Fan Liu, Tamar Nijsten

ABSTRACT

Facial pigmented spots are a common skin aging feature, but genetic predisposition has yet to be thoroughly investigated. We conducted a genome-wide association study for pigmented spots in 2,844 Dutch Europeans from the Rotterdam Study (mean age: 66.9±8.0 years; 47% male). Using semi-automated image analysis of high-resolution digital facial photographs, facial pigmented spots were quantified as the percentage of affected skin area (mean women: 2.0% ±0.9, men: 0.9% ±0.6). We identified genome-wide significant association with pigmented spots at three genetic loci: IRF4 (rs12203592, P=1.8 × 10(-27)), MC1R (compound heterozygosity score, P=2.3 × 10(-24)), and RALY/ASIP (rs6059655, P=1.9 × 10(-9)). In addition, after adjustment for the other three top-associated loci the BNC2 locus demonstrated significant association (rs62543565, P=2.3 × 10(-8)). The association signals observed at all four loci were successfully replicated (P<0.05) in an independent Dutch cohort (Leiden Longevity Study n=599). Although the four genes have previously been associated with skin color variation and skin cancer risk, all association signals remained highly significant (P<2 × 10(-8)) when conditioning the association analyses on skin color. We conclude that genetic variations in IRF4, MC1R, RALY/ASIP, and BNC2 contribute to the acquired amount of facial pigmented spots during aging, through pathways independent of the basal melanin production. More... »

PAGES

1735-1742

References to SciGraph publications

  • 2012-05. How to deal with the early GWAS data when imputing and combining different arrays is necessary in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2014-11. Defining the role of common variation in the genomic and biological architecture of adult human height in NATURE GENETICS
  • 2013-11. The Rotterdam Study: 2014 objectives and design update in EUROPEAN JOURNAL OF EPIDEMIOLOGY
  • 2013-04. A Genome-Wide Association Study in Caucasian Women Points Out a Putative Role of the STXBP5L Gene in Facial Photoaging in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-11. An integrated map of genetic variation from 1,092 human genomes in NATURE
  • 2007-12. Genetic determinants of hair, eye and skin pigmentation in Europeans in NATURE GENETICS
  • 2008-07. Common sequence variants on 20q11.22 confer melanoma susceptibility in NATURE GENETICS
  • 2008-07. Two newly identified genetic determinants of pigmentation in Europeans in NATURE GENETICS
  • 2012-03. Shining a Light on Xeroderma Pigmentosum in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2012-05. MC1R Variant Allele Effects on UVR-Induced Phosphorylation of p38, p53, and DDB2 Repair Protein Responses in Melanocytic Cells in Culture in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-09. Genome-Wide Association Study of Tanning Phenotype in a Population of European Ancestry in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-08. New common variants affecting susceptibility to basal cell carcinoma in NATURE GENETICS
  • 2006-01. Evidence of genetic enrichment for exceptional survival using a family approach: the Leiden Longevity Study in EUROPEAN JOURNAL OF HUMAN GENETICS
  • 2012-03. Development of Lentigines in German and Japanese Women Correlates with Variants in the SLC45A2 Gene in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-08. Genome-wide association study identifies three loci associated with melanoma risk in NATURE GENETICS
  • 2013-02. Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans in HUMAN GENETICS
  • 2010-10. Hundreds of variants clustered in genomic loci and biological pathways affect human height in NATURE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/jid.2015.62

    DOI

    http://dx.doi.org/10.1038/jid.2015.62

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1052738795

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25705849


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    451 rdf:type schema:Organization
     




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