Regulation of the Dynamic Chromatin Architecture of the Epidermal Differentiation Complex Is Mediated by a c-Jun/AP-1-Modulated Enhancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-09

AUTHORS

Inez Y Oh, Danielle M Albea, Zane A Goodwin, Ashley M Quiggle, Breeana P Baker, Ann M Guggisberg, Jessica H Geahlen, Grace M Kroner, Cristina de Guzman Strong

ABSTRACT

The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of differentiation in the developing skin epidermis. Many of the EDC proteins are cross-linked together to form the cornified envelope, an essential and discrete unit of the mammalian skin barrier. The mechanism underlying coordinate transcriptional activation of the EDC is unknown. Within the human EDC, we identified an epidermal-specific regulatory enhancer, 923, which responded to the developmental and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo. Comparative chromosomal conformation capture assays in proliferating and differentiated primary mouse keratinocytes revealed multiple physiologically sensitive chromatin interactions between the 923 enhancer and EDC gene promoters, thus depicting the dynamic chromatin topology of the EDC. We elucidate a mechanistic link between c-Jun/AP-1 and 923, whereby AP-1- and 923-mediated EDC chromatin remodeling are required for functional EDC gene activation. Thus, we identify a critical enhancer/transcription factor axis governing the dynamic regulation of the EDC chromatin architecture and gene expression and provide a framework for future studies toward understanding gene regulation in cutaneous diseases. More... »

PAGES

2371-2380

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2014.44

DOI

http://dx.doi.org/10.1038/jid.2014.44

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1038286258

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24468747


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals, Newborn", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Differentiation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chromatin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enhancer Elements, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Epidermis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Expression Regulation, Developmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Lac Operon", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred Strains", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Transgenic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multigene Family", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pregnancy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "RNA", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factor AP-1", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oh", 
        "givenName": "Inez Y", 
        "id": "sg:person.0671216214.89", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671216214.89"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Albea", 
        "givenName": "Danielle M", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Goodwin", 
        "givenName": "Zane A", 
        "id": "sg:person.01005444614.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005444614.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Quiggle", 
        "givenName": "Ashley M", 
        "id": "sg:person.01053560014.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053560014.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Baker", 
        "givenName": "Breeana P", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guggisberg", 
        "givenName": "Ann M", 
        "id": "sg:person.01241646110.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241646110.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Geahlen", 
        "givenName": "Jessica H", 
        "id": "sg:person.0716064063.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716064063.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kroner", 
        "givenName": "Grace M", 
        "id": "sg:person.01304235014.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304235014.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Washington University in St. Louis", 
          "id": "https://www.grid.ac/institutes/grid.4367.6", 
          "name": [
            "Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address: cstrong@dom.wustl.edu."
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Guzman Strong", 
        "givenName": "Cristina", 
        "id": "sg:person.01244676007.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244676007.20"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1101/gad.543109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000991629"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/hmg/ddq019", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004406292"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004787340", 
          "https://doi.org/10.1038/nature11049"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.jid.5700739", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004790658", 
          "https://doi.org/10.1038/sj.jid.5700739"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.201101148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004964103"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008288156", 
          "https://doi.org/10.1038/sj.onc.1204389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1204389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008288156", 
          "https://doi.org/10.1038/sj.onc.1204389"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.2438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010028319", 
          "https://doi.org/10.1038/ng.2438"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1534-5807(03)00161-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010236746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/geno.1997.4952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010834721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmra1011040", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014184096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2008.12.043", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016572800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1083/jcb.151.2.389", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017995802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.devcel.2012.11.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019476279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2007.243", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021403754", 
          "https://doi.org/10.1038/nprot.2007.243"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.03.051", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024158423"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2012.182", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024311716", 
          "https://doi.org/10.1038/jid.2012.182"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025132392", 
          "https://doi.org/10.1038/nrg2814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg2814", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025132392", 
          "https://doi.org/10.1038/nrg2814"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.313", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027003333", 
          "https://doi.org/10.1038/ng.313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci57416", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027273556"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11247", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029065430", 
          "https://doi.org/10.1038/nature11247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032152372", 
          "https://doi.org/10.1038/nature03922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032152372", 
          "https://doi.org/10.1038/nature03922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032152372", 
          "https://doi.org/10.1038/nature03922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03922", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032152372", 
          "https://doi.org/10.1038/nature03922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1097-2765(02)00781-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032190091"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nprot.2008.50", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032918181", 
          "https://doi.org/10.1038/nprot.2008.50"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/jid.2013.66", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033376170", 
          "https://doi.org/10.1038/jid.2013.66"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2013.04.053", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034096835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034183682", 
          "https://doi.org/10.1038/ng.347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.347", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034183682", 
          "https://doi.org/10.1038/ng.347"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/ard.2010.140533", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036605217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12338501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036609333", 
          "https://doi.org/10.1111/1523-1747.ep12338501"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037606618", 
          "https://doi.org/10.1038/ng1767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1767", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037606618", 
          "https://doi.org/10.1038/ng1767"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature11082", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040271530", 
          "https://doi.org/10.1038/nature11082"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041094404", 
          "https://doi.org/10.1038/ng1743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1743", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041094404", 
          "https://doi.org/10.1038/ng1743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.1017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041174291", 
          "https://doi.org/10.1038/ng.1017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.stem.2009.05.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042574725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature09906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043304663", 
          "https://doi.org/10.1038/nature09906"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000095059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044813597"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045015469", 
          "https://doi.org/10.1038/ng2020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng2020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045015469", 
          "https://doi.org/10.1038/ng2020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gr.3715005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048048079"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.23.090506.123357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050750066"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkm955", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050787802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.231489198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051117469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.179804.111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053365288"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083227192", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09", 
    "datePublishedReg": "2014-09-01", 
    "description": "The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of differentiation in the developing skin epidermis. Many of the EDC proteins are cross-linked together to form the cornified envelope, an essential and discrete unit of the mammalian skin barrier. The mechanism underlying coordinate transcriptional activation of the EDC is unknown. Within the human EDC, we identified an epidermal-specific regulatory enhancer, 923, which responded to the developmental and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo. Comparative chromosomal conformation capture assays in proliferating and differentiated primary mouse keratinocytes revealed multiple physiologically sensitive chromatin interactions between the 923 enhancer and EDC gene promoters, thus depicting the dynamic chromatin topology of the EDC. We elucidate a mechanistic link between c-Jun/AP-1 and 923, whereby AP-1- and 923-mediated EDC chromatin remodeling are required for functional EDC gene activation. Thus, we identify a critical enhancer/transcription factor axis governing the dynamic regulation of the EDC chromatin architecture and gene expression and provide a framework for future studies toward understanding gene regulation in cutaneous diseases. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/jid.2014.44", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2705239", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2705140", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2441453", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438873", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2683663", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1020153", 
        "issn": [
          "0022-202X", 
          "1523-1747"
        ], 
        "name": "Journal of Investigative Dermatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "9", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "134"
      }
    ], 
    "name": "Regulation of the Dynamic Chromatin Architecture of the Epidermal Differentiation Complex Is Mediated by a c-Jun/AP-1-Modulated Enhancer", 
    "pagination": "2371-2380", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "b661e031bb531ca38cc65e2f80f7a95968f2667353c357f9c000d7c72c677d35"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24468747"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0426720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/jid.2014.44"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1038286258"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/jid.2014.44", 
      "https://app.dimensions.ai/details/publication/pub.1038286258"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000554.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/jid/journal/v134/n9/full/jid201444a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'


 

This table displays all metadata directly associated to this object as RDF triples.

343 TRIPLES      21 PREDICATES      87 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/jid.2014.44 schema:about N3035fc71f5f44f98bd58559e73080485
2 N39cb616916764acdb66903738c4e4a6c
3 N3d6b17375c334358b6f596a8e787cd2b
4 N442c879cb6ee4132a3013745983af8e8
5 N568cdba2ee8e4398ad5b0acab026ee04
6 N5bf5798dd31d4c95843785be6390ad10
7 N5ebe6a117ac949aeaa7f5326a54c8403
8 N6c849148ba0246789b11c4a01ef6dc91
9 N77232b81686645bb9d3888e677cd2cf6
10 N8884a83b7ee541de9de6d7f87e868fbe
11 N99cfd76e09e3476894bd3fe6e7c03a9d
12 N9d2fde6dc24e4eb899d192c2d2b46dfa
13 Na12e7997c3594e88b4bfbee8d3685652
14 Na573290fc6924f1ab96ec1e5ebb280bc
15 Nc0776bf7c6ac406babd2c563a359a908
16 Nd438cd9d4456488daa46a8c8fe4f8542
17 anzsrc-for:06
18 anzsrc-for:0604
19 schema:author Naa6b5d60e5c64be687fc66157f6d6704
20 schema:citation sg:pub.10.1038/jid.2012.182
21 sg:pub.10.1038/jid.2013.66
22 sg:pub.10.1038/nature03922
23 sg:pub.10.1038/nature09906
24 sg:pub.10.1038/nature11049
25 sg:pub.10.1038/nature11082
26 sg:pub.10.1038/nature11247
27 sg:pub.10.1038/ng.1017
28 sg:pub.10.1038/ng.2438
29 sg:pub.10.1038/ng.313
30 sg:pub.10.1038/ng.347
31 sg:pub.10.1038/ng1743
32 sg:pub.10.1038/ng1767
33 sg:pub.10.1038/ng2020
34 sg:pub.10.1038/nprot.2007.243
35 sg:pub.10.1038/nprot.2008.50
36 sg:pub.10.1038/nrg2814
37 sg:pub.10.1038/sj.jid.5700739
38 sg:pub.10.1038/sj.onc.1204389
39 sg:pub.10.1111/1523-1747.ep12338501
40 https://app.dimensions.ai/details/publication/pub.1083227192
41 https://doi.org/10.1006/geno.1997.4952
42 https://doi.org/10.1016/j.cell.2008.12.043
43 https://doi.org/10.1016/j.cell.2012.03.051
44 https://doi.org/10.1016/j.cell.2013.04.053
45 https://doi.org/10.1016/j.devcel.2012.11.002
46 https://doi.org/10.1016/j.stem.2009.05.001
47 https://doi.org/10.1016/s1097-2765(02)00781-5
48 https://doi.org/10.1016/s1534-5807(03)00161-8
49 https://doi.org/10.1056/nejmra1011040
50 https://doi.org/10.1073/pnas.231489198
51 https://doi.org/10.1083/jcb.151.2.389
52 https://doi.org/10.1083/jcb.201101148
53 https://doi.org/10.1093/hmg/ddq019
54 https://doi.org/10.1093/nar/gkm955
55 https://doi.org/10.1101/gad.179804.111
56 https://doi.org/10.1101/gad.543109
57 https://doi.org/10.1101/gr.3715005
58 https://doi.org/10.1136/ard.2010.140533
59 https://doi.org/10.1146/annurev.cellbio.23.090506.123357
60 https://doi.org/10.1159/000095059
61 https://doi.org/10.1172/jci57416
62 schema:datePublished 2014-09
63 schema:datePublishedReg 2014-09-01
64 schema:description The epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of differentiation in the developing skin epidermis. Many of the EDC proteins are cross-linked together to form the cornified envelope, an essential and discrete unit of the mammalian skin barrier. The mechanism underlying coordinate transcriptional activation of the EDC is unknown. Within the human EDC, we identified an epidermal-specific regulatory enhancer, 923, which responded to the developmental and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo. Comparative chromosomal conformation capture assays in proliferating and differentiated primary mouse keratinocytes revealed multiple physiologically sensitive chromatin interactions between the 923 enhancer and EDC gene promoters, thus depicting the dynamic chromatin topology of the EDC. We elucidate a mechanistic link between c-Jun/AP-1 and 923, whereby AP-1- and 923-mediated EDC chromatin remodeling are required for functional EDC gene activation. Thus, we identify a critical enhancer/transcription factor axis governing the dynamic regulation of the EDC chromatin architecture and gene expression and provide a framework for future studies toward understanding gene regulation in cutaneous diseases.
65 schema:genre research_article
66 schema:inLanguage en
67 schema:isAccessibleForFree true
68 schema:isPartOf N7804dce8b2c64029b2283cd0f8d10943
69 N7971e1c6ccbb486c965e99c09d7d12ea
70 sg:journal.1020153
71 schema:name Regulation of the Dynamic Chromatin Architecture of the Epidermal Differentiation Complex Is Mediated by a c-Jun/AP-1-Modulated Enhancer
72 schema:pagination 2371-2380
73 schema:productId N0934eeab733c4709b02ead69bcf1a17e
74 N0c09ec06442847adb314fbb0ccdc1b97
75 N552ded7a06804042946e3e9a29deb5eb
76 Nceda8c2db37c41faa374871824ed16d1
77 Ne95905bc4a524a3d99215887010413a4
78 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038286258
79 https://doi.org/10.1038/jid.2014.44
80 schema:sdDatePublished 2019-04-10T20:04
81 schema:sdLicense https://scigraph.springernature.com/explorer/license/
82 schema:sdPublisher N867dccfd789049178eb4a571ec79fd57
83 schema:url http://www.nature.com/jid/journal/v134/n9/full/jid201444a.html
84 sgo:license sg:explorer/license/
85 sgo:sdDataset articles
86 rdf:type schema:ScholarlyArticle
87 N0124003c1b8f410086839f2121d584bf rdf:first sg:person.01241646110.85
88 rdf:rest N2ec37a97189c400db1907aed0d6eb310
89 N0934eeab733c4709b02ead69bcf1a17e schema:name readcube_id
90 schema:value b661e031bb531ca38cc65e2f80f7a95968f2667353c357f9c000d7c72c677d35
91 rdf:type schema:PropertyValue
92 N0c09ec06442847adb314fbb0ccdc1b97 schema:name dimensions_id
93 schema:value pub.1038286258
94 rdf:type schema:PropertyValue
95 N2ec37a97189c400db1907aed0d6eb310 rdf:first sg:person.0716064063.37
96 rdf:rest Nc6605fa124334c07b58fdd527015be9a
97 N3035fc71f5f44f98bd58559e73080485 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Cell Differentiation
99 rdf:type schema:DefinedTerm
100 N39cb616916764acdb66903738c4e4a6c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Pregnancy
102 rdf:type schema:DefinedTerm
103 N3d6b17375c334358b6f596a8e787cd2b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Gene Expression Regulation, Developmental
105 rdf:type schema:DefinedTerm
106 N442c879cb6ee4132a3013745983af8e8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Animals, Newborn
108 rdf:type schema:DefinedTerm
109 N465a5c8989ea4bb69543aa057ceb9ce0 rdf:first sg:person.01053560014.66
110 rdf:rest N6eba471d01494da196957ff2f21d8fbb
111 N552ded7a06804042946e3e9a29deb5eb schema:name pubmed_id
112 schema:value 24468747
113 rdf:type schema:PropertyValue
114 N568cdba2ee8e4398ad5b0acab026ee04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Enhancer Elements, Genetic
116 rdf:type schema:DefinedTerm
117 N5bf5798dd31d4c95843785be6390ad10 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name RNA
119 rdf:type schema:DefinedTerm
120 N5e3d712d4ab244aeb86871769d9f7628 rdf:first N620f0db36b484d2282e679ccd1f51539
121 rdf:rest Nfb4f8fb6bd1240eabc1c7096333d8d3c
122 N5ebe6a117ac949aeaa7f5326a54c8403 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Transcription Factor AP-1
124 rdf:type schema:DefinedTerm
125 N620f0db36b484d2282e679ccd1f51539 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
126 schema:familyName Albea
127 schema:givenName Danielle M
128 rdf:type schema:Person
129 N6c849148ba0246789b11c4a01ef6dc91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Mice, Inbred Strains
131 rdf:type schema:DefinedTerm
132 N6eba471d01494da196957ff2f21d8fbb rdf:first Nfeaebc18695347ff9a56b8c07abfa242
133 rdf:rest N0124003c1b8f410086839f2121d584bf
134 N77232b81686645bb9d3888e677cd2cf6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Female
136 rdf:type schema:DefinedTerm
137 N7804dce8b2c64029b2283cd0f8d10943 schema:issueNumber 9
138 rdf:type schema:PublicationIssue
139 N7971e1c6ccbb486c965e99c09d7d12ea schema:volumeNumber 134
140 rdf:type schema:PublicationVolume
141 N867dccfd789049178eb4a571ec79fd57 schema:name Springer Nature - SN SciGraph project
142 rdf:type schema:Organization
143 N8884a83b7ee541de9de6d7f87e868fbe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Animals
145 rdf:type schema:DefinedTerm
146 N91a2ac369fb748df81e8987ceda148c9 rdf:first sg:person.01244676007.20
147 rdf:rest rdf:nil
148 N99cfd76e09e3476894bd3fe6e7c03a9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
149 schema:name Lac Operon
150 rdf:type schema:DefinedTerm
151 N9d2fde6dc24e4eb899d192c2d2b46dfa schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Humans
153 rdf:type schema:DefinedTerm
154 Na12e7997c3594e88b4bfbee8d3685652 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Epidermis
156 rdf:type schema:DefinedTerm
157 Na573290fc6924f1ab96ec1e5ebb280bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Chromatin
159 rdf:type schema:DefinedTerm
160 Naa6b5d60e5c64be687fc66157f6d6704 rdf:first sg:person.0671216214.89
161 rdf:rest N5e3d712d4ab244aeb86871769d9f7628
162 Nc0776bf7c6ac406babd2c563a359a908 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name Mice, Transgenic
164 rdf:type schema:DefinedTerm
165 Nc6605fa124334c07b58fdd527015be9a rdf:first sg:person.01304235014.44
166 rdf:rest N91a2ac369fb748df81e8987ceda148c9
167 Nceda8c2db37c41faa374871824ed16d1 schema:name doi
168 schema:value 10.1038/jid.2014.44
169 rdf:type schema:PropertyValue
170 Nd438cd9d4456488daa46a8c8fe4f8542 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Multigene Family
172 rdf:type schema:DefinedTerm
173 Ne95905bc4a524a3d99215887010413a4 schema:name nlm_unique_id
174 schema:value 0426720
175 rdf:type schema:PropertyValue
176 Nfb4f8fb6bd1240eabc1c7096333d8d3c rdf:first sg:person.01005444614.09
177 rdf:rest N465a5c8989ea4bb69543aa057ceb9ce0
178 Nfeaebc18695347ff9a56b8c07abfa242 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
179 schema:familyName Baker
180 schema:givenName Breeana P
181 rdf:type schema:Person
182 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
183 schema:name Biological Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
186 schema:name Genetics
187 rdf:type schema:DefinedTerm
188 sg:grant.2438873 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2014.44
189 rdf:type schema:MonetaryGrant
190 sg:grant.2441453 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2014.44
191 rdf:type schema:MonetaryGrant
192 sg:grant.2683663 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2014.44
193 rdf:type schema:MonetaryGrant
194 sg:grant.2705140 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2014.44
195 rdf:type schema:MonetaryGrant
196 sg:grant.2705239 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2014.44
197 rdf:type schema:MonetaryGrant
198 sg:journal.1020153 schema:issn 0022-202X
199 1523-1747
200 schema:name Journal of Investigative Dermatology
201 rdf:type schema:Periodical
202 sg:person.01005444614.09 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
203 schema:familyName Goodwin
204 schema:givenName Zane A
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005444614.09
206 rdf:type schema:Person
207 sg:person.01053560014.66 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
208 schema:familyName Quiggle
209 schema:givenName Ashley M
210 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01053560014.66
211 rdf:type schema:Person
212 sg:person.01241646110.85 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
213 schema:familyName Guggisberg
214 schema:givenName Ann M
215 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01241646110.85
216 rdf:type schema:Person
217 sg:person.01244676007.20 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
218 schema:familyName de Guzman Strong
219 schema:givenName Cristina
220 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244676007.20
221 rdf:type schema:Person
222 sg:person.01304235014.44 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
223 schema:familyName Kroner
224 schema:givenName Grace M
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01304235014.44
226 rdf:type schema:Person
227 sg:person.0671216214.89 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
228 schema:familyName Oh
229 schema:givenName Inez Y
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671216214.89
231 rdf:type schema:Person
232 sg:person.0716064063.37 schema:affiliation https://www.grid.ac/institutes/grid.4367.6
233 schema:familyName Geahlen
234 schema:givenName Jessica H
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0716064063.37
236 rdf:type schema:Person
237 sg:pub.10.1038/jid.2012.182 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024311716
238 https://doi.org/10.1038/jid.2012.182
239 rdf:type schema:CreativeWork
240 sg:pub.10.1038/jid.2013.66 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033376170
241 https://doi.org/10.1038/jid.2013.66
242 rdf:type schema:CreativeWork
243 sg:pub.10.1038/nature03922 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032152372
244 https://doi.org/10.1038/nature03922
245 rdf:type schema:CreativeWork
246 sg:pub.10.1038/nature09906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043304663
247 https://doi.org/10.1038/nature09906
248 rdf:type schema:CreativeWork
249 sg:pub.10.1038/nature11049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004787340
250 https://doi.org/10.1038/nature11049
251 rdf:type schema:CreativeWork
252 sg:pub.10.1038/nature11082 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040271530
253 https://doi.org/10.1038/nature11082
254 rdf:type schema:CreativeWork
255 sg:pub.10.1038/nature11247 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029065430
256 https://doi.org/10.1038/nature11247
257 rdf:type schema:CreativeWork
258 sg:pub.10.1038/ng.1017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041174291
259 https://doi.org/10.1038/ng.1017
260 rdf:type schema:CreativeWork
261 sg:pub.10.1038/ng.2438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010028319
262 https://doi.org/10.1038/ng.2438
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/ng.313 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027003333
265 https://doi.org/10.1038/ng.313
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/ng.347 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034183682
268 https://doi.org/10.1038/ng.347
269 rdf:type schema:CreativeWork
270 sg:pub.10.1038/ng1743 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041094404
271 https://doi.org/10.1038/ng1743
272 rdf:type schema:CreativeWork
273 sg:pub.10.1038/ng1767 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037606618
274 https://doi.org/10.1038/ng1767
275 rdf:type schema:CreativeWork
276 sg:pub.10.1038/ng2020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045015469
277 https://doi.org/10.1038/ng2020
278 rdf:type schema:CreativeWork
279 sg:pub.10.1038/nprot.2007.243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021403754
280 https://doi.org/10.1038/nprot.2007.243
281 rdf:type schema:CreativeWork
282 sg:pub.10.1038/nprot.2008.50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032918181
283 https://doi.org/10.1038/nprot.2008.50
284 rdf:type schema:CreativeWork
285 sg:pub.10.1038/nrg2814 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025132392
286 https://doi.org/10.1038/nrg2814
287 rdf:type schema:CreativeWork
288 sg:pub.10.1038/sj.jid.5700739 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004790658
289 https://doi.org/10.1038/sj.jid.5700739
290 rdf:type schema:CreativeWork
291 sg:pub.10.1038/sj.onc.1204389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008288156
292 https://doi.org/10.1038/sj.onc.1204389
293 rdf:type schema:CreativeWork
294 sg:pub.10.1111/1523-1747.ep12338501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036609333
295 https://doi.org/10.1111/1523-1747.ep12338501
296 rdf:type schema:CreativeWork
297 https://app.dimensions.ai/details/publication/pub.1083227192 schema:CreativeWork
298 https://doi.org/10.1006/geno.1997.4952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010834721
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1016/j.cell.2008.12.043 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016572800
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1016/j.cell.2012.03.051 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024158423
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1016/j.cell.2013.04.053 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034096835
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1016/j.devcel.2012.11.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019476279
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1016/j.stem.2009.05.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042574725
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1016/s1097-2765(02)00781-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032190091
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1016/s1534-5807(03)00161-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010236746
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1056/nejmra1011040 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014184096
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1073/pnas.231489198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051117469
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1083/jcb.151.2.389 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017995802
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1083/jcb.201101148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004964103
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1093/hmg/ddq019 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004406292
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1093/nar/gkm955 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050787802
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1101/gad.179804.111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053365288
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1101/gad.543109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000991629
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1101/gr.3715005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048048079
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1136/ard.2010.140533 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036605217
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1146/annurev.cellbio.23.090506.123357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050750066
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1159/000095059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044813597
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1172/jci57416 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027273556
339 rdf:type schema:CreativeWork
340 https://www.grid.ac/institutes/grid.4367.6 schema:alternateName Washington University in St. Louis
341 schema:name Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA.
342 Division of Dermatology, Department of Internal Medicine, Center for Pharmacogenomics, Center for the Study of Itch, Washington University School of Medicine, St Louis, Missouri, USA. Electronic address: cstrong@dom.wustl.edu.
343 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...