Ontology type: schema:ScholarlyArticle Open Access: True
2014-09
AUTHORSInez Y Oh, Danielle M Albea, Zane A Goodwin, Ashley M Quiggle, Breeana P Baker, Ann M Guggisberg, Jessica H Geahlen, Grace M Kroner, Cristina de Guzman Strong
ABSTRACTThe epidermal differentiation complex (EDC) locus comprises a syntenic and linear cluster of genes whose concomitant expression is a hallmark feature of differentiation in the developing skin epidermis. Many of the EDC proteins are cross-linked together to form the cornified envelope, an essential and discrete unit of the mammalian skin barrier. The mechanism underlying coordinate transcriptional activation of the EDC is unknown. Within the human EDC, we identified an epidermal-specific regulatory enhancer, 923, which responded to the developmental and spatiotemporal cues at the onset of epidermal differentiation in the mouse embryo. Comparative chromosomal conformation capture assays in proliferating and differentiated primary mouse keratinocytes revealed multiple physiologically sensitive chromatin interactions between the 923 enhancer and EDC gene promoters, thus depicting the dynamic chromatin topology of the EDC. We elucidate a mechanistic link between c-Jun/AP-1 and 923, whereby AP-1- and 923-mediated EDC chromatin remodeling are required for functional EDC gene activation. Thus, we identify a critical enhancer/transcription factor axis governing the dynamic regulation of the EDC chromatin architecture and gene expression and provide a framework for future studies toward understanding gene regulation in cutaneous diseases. More... »
PAGES2371-2380
http://scigraph.springernature.com/pub.10.1038/jid.2014.44
DOIhttp://dx.doi.org/10.1038/jid.2014.44
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/24468747
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]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jid.2014.44'
This table displays all metadata directly associated to this object as RDF triples.
343 TRIPLES
21 PREDICATES
87 URIs
37 LITERALS
25 BLANK NODES