Immunogenicity of Biotherapy Used in Psoriasis: The Science Behind the Scenes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2015-01

AUTHORS

Denis Jullien, Jörg C Prinz, Frank O Nestle

ABSTRACT

A potential limitation in the use of biologic drugs used to treat psoriasis is the development of anti-drug antibodies (ADAs). Many factors contribute to this unwanted immune response, from the product itself, to its mode of administration, the underlying disease, and patient characteristics. ADAs may decrease the efficacy of biologic drugs by neutralizing them or modifying their clearance and may account for hypersensitivity reactions. This article reviews the scientific basis of immunogenicity and the mechanisms by which it affects clinical outcomes. It also considers testing for immunogenicity and how biologic therapy of psoriasis may be tailored on the basis of immunogenicity. More... »

PAGES

31-38

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2014.295

DOI

http://dx.doi.org/10.1038/jid.2014.295

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003404878

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25120005


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