Allele-Specific Cytokine Responses at the HLA-C Locus: Implications for Psoriasis View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-03

AUTHORS

Christian Hundhausen, Anna Bertoni, Rose K Mak, Elisabetta Botti, Paola Di Meglio, Alex Clop, Ute Laggner, Sergio Chimenti, Adrian C Hayday, Jonathan N Barker, Richard C Trembath, Francesca Capon, Frank O Nestle

ABSTRACT

Psoriasis is an inflammatory skin disorder that is inherited as a complex trait. Genetic studies have repeatedly highlighted HLA-C as the major determinant for psoriasis susceptibility, with the Cw*0602 allele conferring significant disease risk in a wide range of populations. Despite the potential importance of HLA-C variation in psoriasis, either via an effect on peptide presentation or immuno-inhibitory activity, allele-specific expression patterns have not been investigated. Here, we used reporter assays to characterize two regulatory variants, which virtually abolished the response to tumor necrosis factor (TNF)-α (rs2524094) and IFN-γ (rs10657191) in HLA-Cw*0602 and a cluster of related alleles. We validated these findings through the analysis of HLA-Cw*0602 expression in primary keratinocytes treated with TNF-α and IFN-γ. Finally, we showed that HLA-Cw*0602 transcripts are not increased in psoriatic skin lesions, despite highly elevated TNF-α levels. Thus, our findings demonstrate the presence of allele-specific differences in HLA-C expression and indicate that HLA-Cw*0602 is unresponsive to upregulation by key proinflammatory cytokines in psoriasis. These data pave the way for functional studies into the pathogenic role of the major psoriasis susceptibility allele. More... »

PAGES

635-641

References to SciGraph publications

  • 2007-01. Psoriasis: genetic associations and immune system changes in GENES & IMMUNITY
  • 2007-02. HLA-C Expression Pattern Is Spatially Different between Psoriasis and Eczema Skin Lesions in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2007-10. Immunopathogenesis of Psoriasis in CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
  • 2009-02. Genome-wide scan reveals association of psoriasis with IL-23 and NF-κB pathways in NATURE GENETICS
  • 1999-10. HLA-Cw6 and the Genetic Predisposition to Psoriasis: a Meta-Analysis of Published Serologic Studies in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-06. The IL-23/Th17 Axis in the Immunopathogenesis of Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-11. Association analyses identify six new psoriasis susceptibility loci in the Chinese population in NATURE GENETICS
  • 2010-11. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2 in NATURE GENETICS
  • 2005-10. Distinct HLA-C/KIR Genotype Profile Associates with Guttate Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2008-06. Analyzing real-time PCR data by the comparative CT method in NATURE PROTOCOLS
  • 2005-03. MHC class I molecules and kirs in human history, health and survival in NATURE REVIEWS IMMUNOLOGY
  • 2005-01. Proteome Analysis of Skin Distinguishes Acute Guttate from Chronic Plaque Psoriasis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2010-11. Genome-wide association analysis identifies three psoriasis susceptibility loci in NATURE GENETICS
  • 2010-11. A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 in NATURE GENETICS
  • 2004-09. Identification of HLA-Cw6.02 and HLA-Cw7.01 allele-specific binding motifs by screening synthetic peptide libraries in IMMUNOGENETICS
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/jid.2011.378

    DOI

    http://dx.doi.org/10.1038/jid.2011.378

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1015336740

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22113476


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