It’s All about Position: The Basal Layer of Human Epidermis Is Particularly Susceptible to Different Types of Sunlight-Induced DNA Damage View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-02

AUTHORS

Gary M Halliday, Jean Cadet

ABSTRACT

In this issue, Tewari et al. show that although UVB most effectively causes cyclobutane pyrimidine dimers (CPDs) at the human epidermal surface, UVA-induced CPDs predominate in the basal layer. Previous studies found higher accumulation of UVA-induced 8-oxo-7,8-dihydro-2'-deoxyguanosine and mutations in the basal layer. Therefore, the epidermal basal layer is particularly sensitive to UVA-induced genetic damage and the formation of mutations. More... »

PAGES

265-267

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2011.281

DOI

http://dx.doi.org/10.1038/jid.2011.281

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1024308191

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22241442


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