TLR2 Expression Is Increased in Rosacea and Stimulates Enhanced Serine Protease Production by Keratinocytes View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-03

AUTHORS

Kenshi Yamasaki, Kimberly Kanada, Daniel T Macleod, Andrew W Borkowski, Shin Morizane, Teruaki Nakatsuji, Anna L Cogen, Richard L Gallo

ABSTRACT

A diverse environment challenges skin to maintain temperature, hydration, and electrolyte balance while also maintaining normal immunological function. Rosacea is a common skin disease that manifests unique inflammatory responses to normal environmental stimuli. We hypothesized that abnormal function of innate immune pattern recognition could explain the enhanced sensitivity of patients with rosacea, and observed that the epidermis of patients with rosacea expressed higher amounts of Toll-like receptor 2 (TLR2) than normal patients. Increased expression of TLR2 was not seen in other inflammatory skin disorders such as atopic dermatitis or psoriasis. Overexpression of TLR2 on keratinocytes, treatment with TLR2 ligands, and analysis of TLR2-deficient mice resulted in a calcium-dependent release of kallikrein 5 from keratinocytes, a critical protease involved in the pathogenesis of rosacea. These observations show that abnormal TLR2 function may explain enhanced inflammatory responses to environmental stimuli and can act as a critical element in the pathogenesis of rosacea. More... »

PAGES

688-697

References to SciGraph publications

  • 2005-02. LEKTI Is Localized in Lamellar Granules, Separated from KLK5 and KLK7, and Is Secreted in the Extracellular Spaces of the Superficial Stratum Granulosum in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2007-01. Breach Delivery: Increased Solute Uptake Points to a Defective Skin Barrier in Atopic Dermatitis in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1985-06. Ionic Calcium Reservoirs in Mammalian Epidermis: Ultrastructural Localization by Ion-Capture Cytochemistry in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-01. Spink5-deficient mice mimic Netherton syndrome through degradation of desmoglein 1 by epidermal protease hyperactivity in NATURE GENETICS
  • 1988-05. A Model for in Vitro Studies of Epidermal Homeostasis: Proliferation and Involucrin Synthesis by Cultured Human Keratinocytes During Recovery After Stripping Off the Suprabasal Layers in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 1998-12. Acute Barrier Perturbation Abolishes the Ca2+ and K+ Gradients in Murine Epidermis: Quantitative Measurement Using PIXE in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2008-04. Co-Regulation and Interdependence of the Mammalian Epidermal Permeability and Antimicrobial Barriers in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2000-06. Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome in NATURE GENETICS
  • 2010-05. Kallikrein Expression and Cathelicidin Processing Are Independently Controlled in Keratinocytes by Calcium, Vitamin D3, and Retinoic Acid in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2005-02. Keratinocytes Store the Antimicrobial Peptide Cathelicidin in Lamellar Bodies in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2009-12. Commensal bacteria regulate Toll-like receptor 3–dependent inflammation after skin injury in NATURE MEDICINE
  • 2009-10. Antimicrobial Property of Lauric Acid Against Propionibacterium Acnes: Its Therapeutic Potential for Inflammatory Acne Vulgaris in JOURNAL OF INVESTIGATIVE DERMATOLOGY
  • 2007-08. Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea in NATURE MEDICINE
  • 2005-11. Regulation of lung injury and repair by Toll-like receptors and hyaluronan in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/jid.2010.351

    DOI

    http://dx.doi.org/10.1038/jid.2010.351

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1035430339

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21107351


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jid.2010.351'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jid.2010.351'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jid.2010.351'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jid.2010.351'


     

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