Diminished Neural and Cognitive Responses to Facial Expressions of Disgust in Patients with Psoriasis: A Functional Magnetic Resonance Imaging Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-11

AUTHORS

C Elise Kleyn, Shane McKie, Andrew R Ross, Daniela Montaldi, Lloyd J Gregory, Rebecca Elliott, Clare L Isaacs, Ian M Anderson, Helen L Richards, J F William Deakin, Donal G Fortune, Christopher E M Griffiths

ABSTRACT

Psoriasis produces significant psychosocial disability; however, little is understood about the neurocognitive mechanisms that mediate the adverse consequences of the social stigma associated with visible skin lesions, such as disgusted facial expressions of others. Both the feeling of disgust and the observation of disgust in others are known to activate the insula cortex. We investigated whether the social impact of psoriasis is associated with altered cognitive processing of disgust using (i) a covert recognition of faces task conducted using functional magnetic resonance imaging (fMRI) and (ii) the facial expression recognition task (FERT), a decision-making task, conducted outside the scanner to assess the ability to recognize overtly different intensities of disgust. Thirteen right-handed male patients with psoriasis and 13 age-matched male controls were included. In the fMRI study, psoriasis patients had significantly (P<0.005) smaller signal responses to disgusted faces in the bilateral insular cortex compared with healthy controls. These data were corroborated by FERT, in that patients were less able than controls to identify all intensities of disgust tested. We hypothesize that patients with psoriasis, in this case male patients, develop a coping mechanism to protect them from stressful emotional responses by blocking the processing of disgusted facial expressions. More... »

PAGES

2613-2619

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2009.152

DOI

http://dx.doi.org/10.1038/jid.2009.152

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1011182734

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19710691


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