Matriptase-Deficient Mice Exhibit Ichthyotic Skin with a Selective Shift in Skin Microbiota View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

Tiffany C Scharschmidt, Karin List, Elizabeth A Grice, Roman Szabo, Gabriel Renaud, Chyi-Chia R Lee, Tyra G Wolfsberg, Thomas H Bugge, Julia A Segre

ABSTRACT

Suppressor of tumorigenicity 14 (St14) encodes matriptase, a serine protease, which regulates processing of profilaggrin to filaggin in vivo. Here, we report that transgenic mice with 1% of wild-type St14 levels (St14(hypo/-)) display aberrant processing of profilaggrin and model human ichthyotic skin phenotypes. Scaling of the skin appears at 1 week of age with underlying epidermal acanthosis and orthohyperkeratosis as well as a CD4+ T-cell dermal infiltrate. Upregulation of antimicrobial peptides occurs when challenged by exposure to the postnatal environment. Direct genomic sequencing of bacterial 16S rRNA genes to query microbial diversity identifies a significant shift in both phylogeny and community structure between St14(hypo/-) mice and control littermates. St14(hypo/-) mice have a selective shift in resident skin microbiota with a decrease of the dominant genus of skin bacteria, Pseudomonas and an accompanying increase of Corynebacterium and Streptococcus. St14(hypo/-) mice provide early evidence that the cutaneous microbiome can be specifically altered by genetic state, which may play an important role in modulating skin disease. More... »

PAGES

2435-2442

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2009.104

DOI

http://dx.doi.org/10.1038/jid.2009.104

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1009201303

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19387477


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