Profibrinolytic Effects of Metalloproteinases during Skin Wound Healing in the Absence of Plasminogen View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-08

AUTHORS

Kirsty A Green, Kasper Almholt, Michael Ploug, Birgitte Rønø, Francis J Castellino, Morten Johnsen, Thomas H Bugge, John Rømer, Leif R Lund

ABSTRACT

Genetic ablation of plasminogen (Plg) and pharmacological inhibition of metalloproteinase activity by galardin delay skin wound healing in mice, whereas the combined inhibition of these two enzyme systems completely prevents healing. In this study, the impact of plasmin and metalloproteinases as profibrinolytic enzymes has been investigated by comparing skin wound healing in the absence and presence of fibrin. Plg deficiency impairs skin wound healing kinetics, but this delay is only partially restored in the absence of fibrin. This suggests that plasmin-mediated fibrinolysis is the primary, but not the exclusive, requirement for healing of wounds in these mice. In addition, we observe that lack of fibrin reduces Plg activation significantly during wound healing. The profibrinolytic role of metalloproteinases is revealed by the finding that lack of fibrin partially restores the otherwise arrested healing of Plg-deficient wounds after metalloproteinase inhibition. In conclusion, the residual impairment of skin wound healing in the absence of fibrin suggests the existence of a fibrin-independent substrate(s) for plasmin and metalloproteinases. Furthermore, these in vivo data reveal that galardin-sensitive metalloproteinases mediate compensatory fibrinolysis to facilitate wound healing in the absence of plasmin. More... »

PAGES

2092-2101

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jid.2008.54

DOI

http://dx.doi.org/10.1038/jid.2008.54

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033618668

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18337830


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dipeptides", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fibrinolysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Keratinocytes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 13", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 3", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase 9", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Matrix Metalloproteinase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Inbred C57BL", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mice, Knockout", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Plasminogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protease Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Skin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Wound Healing", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "familyName": "Green", 
        "givenName": "Kirsty A", 
        "id": "sg:person.01354524215.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354524215.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Almholt", 
        "givenName": "Kasper", 
        "id": "sg:person.0745346515.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745346515.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ploug", 
        "givenName": "Michael", 
        "id": "sg:person.0602704340.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602704340.96"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "R\u00f8n\u00f8", 
        "givenName": "Birgitte", 
        "id": "sg:person.0620233731.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620233731.44"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Castellino", 
        "givenName": "Francis J", 
        "id": "sg:person.01320632174.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320632174.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Copenhagen", 
          "id": "https://www.grid.ac/institutes/grid.5254.6", 
          "name": [
            "Institute of Molecular Biology, University of Copenhagen, Copenhagen Biocenter, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johnsen", 
        "givenName": "Morten", 
        "id": "sg:person.01302332462.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302332462.11"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Bugge", 
        "givenName": "Thomas H", 
        "id": "sg:person.014711620557.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark"
          ], 
          "type": "Organization"
        }, 
        "familyName": "R\u00f8mer", 
        "givenName": "John", 
        "id": "sg:person.0653775425.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653775425.75"
        ], 
        "type": "Person"
      }, 
      {
        "familyName": "Lund", 
        "givenName": "Leif R", 
        "id": "sg:person.0613762763.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613762763.19"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1182/blood.v97.12.3691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000534900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)64582-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002097070"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81768-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003077947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1161/01.atv.18.7.1035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004214594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006149196", 
          "https://doi.org/10.1038/nrg1111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrg1111", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006149196", 
          "https://doi.org/10.1038/nrg1111"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12486833", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008612583", 
          "https://doi.org/10.1111/1523-1747.ep12486833"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm2125", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009918515", 
          "https://doi.org/10.1038/nrm2125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12373187", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010172526", 
          "https://doi.org/10.1111/1523-1747.ep12373187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0402784101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010733726"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0396-287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012515929", 
          "https://doi.org/10.1038/nm0396-287"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci116719", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015082624"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/excr.1998.4049", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022062762"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/gad.9.7.794", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022359688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1111/1523-1747.ep12461511", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023401430", 
          "https://doi.org/10.1111/1523-1747.ep12461511"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0065-230x(08)60028-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023925999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/emboj/18.17.4645", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027076933"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20010815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027728020"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.84.16.5788", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031558531"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.93.12.5899", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032569991"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2141.1976.tb00953.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032580515"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1242/dev.00642", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037017051"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc745", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039076536", 
          "https://doi.org/10.1038/nrc745"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81390-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041505425"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00139-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041975732"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2006.01861.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042869323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1538-7836.2006.01861.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042869323"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.96.26.15143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043150703"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047628928", 
          "https://doi.org/10.1038/35060059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35060059", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047628928", 
          "https://doi.org/10.1038/35060059"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01534.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048953000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1699-0463.1999.tb01534.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048953000"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1038/sj.emboj.7601173", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049190342"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050954779", 
          "https://doi.org/10.1038/sj.onc.1201869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1201869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050954779", 
          "https://doi.org/10.1038/sj.onc.1201869"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi00146a017", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055162573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm970494j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055958422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/jm970494j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055958422"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-2007-996099", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1057522312"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1160/th04-11-0724", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063290345"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074703144", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1081601702", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082576474", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1055/s-0038-1656074", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083102807"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083124322", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1083214912", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2008-08", 
    "datePublishedReg": "2008-08-01", 
    "description": "Genetic ablation of plasminogen (Plg) and pharmacological inhibition of metalloproteinase activity by galardin delay skin wound healing in mice, whereas the combined inhibition of these two enzyme systems completely prevents healing. In this study, the impact of plasmin and metalloproteinases as profibrinolytic enzymes has been investigated by comparing skin wound healing in the absence and presence of fibrin. Plg deficiency impairs skin wound healing kinetics, but this delay is only partially restored in the absence of fibrin. This suggests that plasmin-mediated fibrinolysis is the primary, but not the exclusive, requirement for healing of wounds in these mice. In addition, we observe that lack of fibrin reduces Plg activation significantly during wound healing. The profibrinolytic role of metalloproteinases is revealed by the finding that lack of fibrin partially restores the otherwise arrested healing of Plg-deficient wounds after metalloproteinase inhibition. In conclusion, the residual impairment of skin wound healing in the absence of fibrin suggests the existence of a fibrin-independent substrate(s) for plasmin and metalloproteinases. Furthermore, these in vivo data reveal that galardin-sensitive metalloproteinases mediate compensatory fibrinolysis to facilitate wound healing in the absence of plasmin.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1038/jid.2008.54", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2715908", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2724655", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7133854", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1020153", 
        "issn": [
          "0022-202X", 
          "1523-1747"
        ], 
        "name": "Journal of Investigative Dermatology", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "8", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "128"
      }
    ], 
    "name": "Profibrinolytic Effects of Metalloproteinases during Skin Wound Healing in the Absence of Plasminogen", 
    "pagination": "2092-2101", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a025d34dd7982f179db7f3437ca1f3eca3811085c5fc17e8e32418dcaa0a0078"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18337830"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "0426720"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/jid.2008.54"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1033618668"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/jid.2008.54", 
      "https://app.dimensions.ai/details/publication/pub.1033618668"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T16:29", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8669_00000425.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://www.nature.com/jid/journal/v128/n8/full/jid200854a.html"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jid.2008.54'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jid.2008.54'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jid.2008.54'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jid.2008.54'


 

This table displays all metadata directly associated to this object as RDF triples.

324 TRIPLES      21 PREDICATES      86 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/jid.2008.54 schema:about N01c391adfe9a4589b6595054fc3c410e
2 N025fd9bd3f6347da918d96f6c20c0f31
3 N0884c4bb727a4550b9f6b50f7186d31a
4 N116e8b850c624fabbcd9d38ef9ae996c
5 N2c70cb67708a4de6a8089108a01afa77
6 N3e0271f6ecc0469e9a92556a2278cd71
7 N3e6ae0c15017408c965424347eb1dc48
8 N4139b53674c64c93b2b2616fe0590f99
9 N564a882568bd4074bf0a066855012619
10 N74542d1f62834c83a63de8958538600c
11 N7f8d405926a24a0d84c8928f236ac4d8
12 Ndba8813327e24a75a17fbbb28b9d3b56
13 Ne3393a549fc44c6db8d8d6f7ecffb057
14 Ne372ee85f02943f4ae231193fec39f63
15 Ne6c40884e2a44411858debcc4b4b1c76
16 Nec79ac6a726c40b4a16d35f74db9b81f
17 Nfa1d0472b680498caee2be614448bce3
18 anzsrc-for:11
19 anzsrc-for:1103
20 schema:author N164d709d15fb417497042e95a93f327e
21 schema:citation sg:pub.10.1038/35060059
22 sg:pub.10.1038/nm0396-287
23 sg:pub.10.1038/nrc745
24 sg:pub.10.1038/nrg1111
25 sg:pub.10.1038/nrm2125
26 sg:pub.10.1038/sj.onc.1201869
27 sg:pub.10.1111/1523-1747.ep12373187
28 sg:pub.10.1111/1523-1747.ep12461511
29 sg:pub.10.1111/1523-1747.ep12486833
30 https://app.dimensions.ai/details/publication/pub.1074703144
31 https://app.dimensions.ai/details/publication/pub.1081601702
32 https://app.dimensions.ai/details/publication/pub.1082576474
33 https://app.dimensions.ai/details/publication/pub.1083124322
34 https://app.dimensions.ai/details/publication/pub.1083214912
35 https://doi.org/10.1006/excr.1998.4049
36 https://doi.org/10.1016/s0002-9440(10)64582-8
37 https://doi.org/10.1016/s0065-230x(08)60028-7
38 https://doi.org/10.1016/s0092-8674(00)00139-2
39 https://doi.org/10.1016/s0092-8674(00)81390-2
40 https://doi.org/10.1016/s0092-8674(00)81768-7
41 https://doi.org/10.1021/bi00146a017
42 https://doi.org/10.1021/jm970494j
43 https://doi.org/10.1038/sj.emboj.7601173
44 https://doi.org/10.1055/s-0038-1656074
45 https://doi.org/10.1055/s-2007-996099
46 https://doi.org/10.1073/pnas.0402784101
47 https://doi.org/10.1073/pnas.84.16.5788
48 https://doi.org/10.1073/pnas.93.12.5899
49 https://doi.org/10.1073/pnas.96.26.15143
50 https://doi.org/10.1084/jem.20010815
51 https://doi.org/10.1093/emboj/18.17.4645
52 https://doi.org/10.1101/gad.9.7.794
53 https://doi.org/10.1111/j.1365-2141.1976.tb00953.x
54 https://doi.org/10.1111/j.1538-7836.2006.01861.x
55 https://doi.org/10.1111/j.1699-0463.1999.tb01534.x
56 https://doi.org/10.1160/th04-11-0724
57 https://doi.org/10.1161/01.atv.18.7.1035
58 https://doi.org/10.1172/jci116719
59 https://doi.org/10.1182/blood.v97.12.3691
60 https://doi.org/10.1242/dev.00642
61 schema:datePublished 2008-08
62 schema:datePublishedReg 2008-08-01
63 schema:description Genetic ablation of plasminogen (Plg) and pharmacological inhibition of metalloproteinase activity by galardin delay skin wound healing in mice, whereas the combined inhibition of these two enzyme systems completely prevents healing. In this study, the impact of plasmin and metalloproteinases as profibrinolytic enzymes has been investigated by comparing skin wound healing in the absence and presence of fibrin. Plg deficiency impairs skin wound healing kinetics, but this delay is only partially restored in the absence of fibrin. This suggests that plasmin-mediated fibrinolysis is the primary, but not the exclusive, requirement for healing of wounds in these mice. In addition, we observe that lack of fibrin reduces Plg activation significantly during wound healing. The profibrinolytic role of metalloproteinases is revealed by the finding that lack of fibrin partially restores the otherwise arrested healing of Plg-deficient wounds after metalloproteinase inhibition. In conclusion, the residual impairment of skin wound healing in the absence of fibrin suggests the existence of a fibrin-independent substrate(s) for plasmin and metalloproteinases. Furthermore, these in vivo data reveal that galardin-sensitive metalloproteinases mediate compensatory fibrinolysis to facilitate wound healing in the absence of plasmin.
64 schema:genre research_article
65 schema:inLanguage en
66 schema:isAccessibleForFree true
67 schema:isPartOf N7976d43a0c484f788a08f8489a52dbaf
68 Nb6124cc85fc94e3f853c2fe2eb521733
69 sg:journal.1020153
70 schema:name Profibrinolytic Effects of Metalloproteinases during Skin Wound Healing in the Absence of Plasminogen
71 schema:pagination 2092-2101
72 schema:productId N705e33ad82ec4616b949a4cf35ccac84
73 N7c722b46395a4559b9b592a6ac089081
74 N8848d8fc6d5a40e1900e53b6c440f931
75 N98d352c5af65462faf5f182186986954
76 Naf40f632212244b28f366133a7d68b48
77 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033618668
78 https://doi.org/10.1038/jid.2008.54
79 schema:sdDatePublished 2019-04-10T16:29
80 schema:sdLicense https://scigraph.springernature.com/explorer/license/
81 schema:sdPublisher N33d2593fde514b36b8757d0ca04a1131
82 schema:url http://www.nature.com/jid/journal/v128/n8/full/jid200854a.html
83 sgo:license sg:explorer/license/
84 sgo:sdDataset articles
85 rdf:type schema:ScholarlyArticle
86 N01c391adfe9a4589b6595054fc3c410e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Matrix Metalloproteinase 9
88 rdf:type schema:DefinedTerm
89 N025fd9bd3f6347da918d96f6c20c0f31 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Mice
91 rdf:type schema:DefinedTerm
92 N0884c4bb727a4550b9f6b50f7186d31a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Fibrinolysis
94 rdf:type schema:DefinedTerm
95 N116e8b850c624fabbcd9d38ef9ae996c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Keratinocytes
97 rdf:type schema:DefinedTerm
98 N128b53938b1548a2a6bbc5cfe8bef031 rdf:first sg:person.01320632174.05
99 rdf:rest N5f69cfa50be744da90a7990fe25790d1
100 N164d709d15fb417497042e95a93f327e rdf:first sg:person.01354524215.90
101 rdf:rest N7dcc553629a645f9bd51b1555eaa98fd
102 N2c70cb67708a4de6a8089108a01afa77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Mice, Knockout
104 rdf:type schema:DefinedTerm
105 N328c2fb6d8d743b18e168e53a04fe77f rdf:first sg:person.0602704340.96
106 rdf:rest N334e535ee9c442158e982d4efb03d51b
107 N334e535ee9c442158e982d4efb03d51b rdf:first sg:person.0620233731.44
108 rdf:rest N128b53938b1548a2a6bbc5cfe8bef031
109 N33d2593fde514b36b8757d0ca04a1131 schema:name Springer Nature - SN SciGraph project
110 rdf:type schema:Organization
111 N3520753d15ff4975aac3f24f96300b21 schema:name Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
112 rdf:type schema:Organization
113 N3e0271f6ecc0469e9a92556a2278cd71 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Fibrinogen
115 rdf:type schema:DefinedTerm
116 N3e6ae0c15017408c965424347eb1dc48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Matrix Metalloproteinase 3
118 rdf:type schema:DefinedTerm
119 N4139b53674c64c93b2b2616fe0590f99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Protease Inhibitors
121 rdf:type schema:DefinedTerm
122 N4b025e331d6e4fadae08b133abbb4696 rdf:first sg:person.0653775425.75
123 rdf:rest N971c696b0beb47a690ee9c04bc46c1f9
124 N564a882568bd4074bf0a066855012619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Dipeptides
126 rdf:type schema:DefinedTerm
127 N5f69cfa50be744da90a7990fe25790d1 rdf:first sg:person.01302332462.11
128 rdf:rest Nd8d5e3a19644479681c70ab4bd784454
129 N705e33ad82ec4616b949a4cf35ccac84 schema:name nlm_unique_id
130 schema:value 0426720
131 rdf:type schema:PropertyValue
132 N74542d1f62834c83a63de8958538600c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Fibrin
134 rdf:type schema:DefinedTerm
135 N7976d43a0c484f788a08f8489a52dbaf schema:issueNumber 8
136 rdf:type schema:PublicationIssue
137 N7c722b46395a4559b9b592a6ac089081 schema:name readcube_id
138 schema:value a025d34dd7982f179db7f3437ca1f3eca3811085c5fc17e8e32418dcaa0a0078
139 rdf:type schema:PropertyValue
140 N7dcc553629a645f9bd51b1555eaa98fd rdf:first sg:person.0745346515.27
141 rdf:rest N328c2fb6d8d743b18e168e53a04fe77f
142 N7f8d405926a24a0d84c8928f236ac4d8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Wound Healing
144 rdf:type schema:DefinedTerm
145 N8848d8fc6d5a40e1900e53b6c440f931 schema:name doi
146 schema:value 10.1038/jid.2008.54
147 rdf:type schema:PropertyValue
148 N8da0bb33f03344db938cf21598e15766 schema:name Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
149 rdf:type schema:Organization
150 N971c696b0beb47a690ee9c04bc46c1f9 rdf:first sg:person.0613762763.19
151 rdf:rest rdf:nil
152 N98d352c5af65462faf5f182186986954 schema:name pubmed_id
153 schema:value 18337830
154 rdf:type schema:PropertyValue
155 Naf40f632212244b28f366133a7d68b48 schema:name dimensions_id
156 schema:value pub.1033618668
157 rdf:type schema:PropertyValue
158 Nb6124cc85fc94e3f853c2fe2eb521733 schema:volumeNumber 128
159 rdf:type schema:PublicationVolume
160 Nca21e113afee42e4be07e8839ab4234b schema:name Finsen Laboratory, Rigshospitalet, Copenhagen Biocenter, Copenhagen, Denmark
161 rdf:type schema:Organization
162 Nd8d5e3a19644479681c70ab4bd784454 rdf:first sg:person.014711620557.63
163 rdf:rest N4b025e331d6e4fadae08b133abbb4696
164 Ndba8813327e24a75a17fbbb28b9d3b56 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Animals
166 rdf:type schema:DefinedTerm
167 Ne3393a549fc44c6db8d8d6f7ecffb057 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Matrix Metalloproteinase Inhibitors
169 rdf:type schema:DefinedTerm
170 Ne372ee85f02943f4ae231193fec39f63 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name Plasminogen
172 rdf:type schema:DefinedTerm
173 Ne6c40884e2a44411858debcc4b4b1c76 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
174 schema:name Mice, Inbred C57BL
175 rdf:type schema:DefinedTerm
176 Nec79ac6a726c40b4a16d35f74db9b81f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Skin
178 rdf:type schema:DefinedTerm
179 Nfa1d0472b680498caee2be614448bce3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Matrix Metalloproteinase 13
181 rdf:type schema:DefinedTerm
182 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
183 schema:name Medical and Health Sciences
184 rdf:type schema:DefinedTerm
185 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
186 schema:name Clinical Sciences
187 rdf:type schema:DefinedTerm
188 sg:grant.2715908 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2008.54
189 rdf:type schema:MonetaryGrant
190 sg:grant.2724655 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2008.54
191 rdf:type schema:MonetaryGrant
192 sg:grant.7133854 http://pending.schema.org/fundedItem sg:pub.10.1038/jid.2008.54
193 rdf:type schema:MonetaryGrant
194 sg:journal.1020153 schema:issn 0022-202X
195 1523-1747
196 schema:name Journal of Investigative Dermatology
197 rdf:type schema:Periodical
198 sg:person.01302332462.11 schema:affiliation https://www.grid.ac/institutes/grid.5254.6
199 schema:familyName Johnsen
200 schema:givenName Morten
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01302332462.11
202 rdf:type schema:Person
203 sg:person.01320632174.05 schema:familyName Castellino
204 schema:givenName Francis J
205 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01320632174.05
206 rdf:type schema:Person
207 sg:person.01354524215.90 schema:familyName Green
208 schema:givenName Kirsty A
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354524215.90
210 rdf:type schema:Person
211 sg:person.014711620557.63 schema:familyName Bugge
212 schema:givenName Thomas H
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014711620557.63
214 rdf:type schema:Person
215 sg:person.0602704340.96 schema:affiliation Nca21e113afee42e4be07e8839ab4234b
216 schema:familyName Ploug
217 schema:givenName Michael
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602704340.96
219 rdf:type schema:Person
220 sg:person.0613762763.19 schema:familyName Lund
221 schema:givenName Leif R
222 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0613762763.19
223 rdf:type schema:Person
224 sg:person.0620233731.44 schema:familyName Rønø
225 schema:givenName Birgitte
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0620233731.44
227 rdf:type schema:Person
228 sg:person.0653775425.75 schema:affiliation N3520753d15ff4975aac3f24f96300b21
229 schema:familyName Rømer
230 schema:givenName John
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0653775425.75
232 rdf:type schema:Person
233 sg:person.0745346515.27 schema:affiliation N8da0bb33f03344db938cf21598e15766
234 schema:familyName Almholt
235 schema:givenName Kasper
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0745346515.27
237 rdf:type schema:Person
238 sg:pub.10.1038/35060059 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047628928
239 https://doi.org/10.1038/35060059
240 rdf:type schema:CreativeWork
241 sg:pub.10.1038/nm0396-287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012515929
242 https://doi.org/10.1038/nm0396-287
243 rdf:type schema:CreativeWork
244 sg:pub.10.1038/nrc745 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039076536
245 https://doi.org/10.1038/nrc745
246 rdf:type schema:CreativeWork
247 sg:pub.10.1038/nrg1111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006149196
248 https://doi.org/10.1038/nrg1111
249 rdf:type schema:CreativeWork
250 sg:pub.10.1038/nrm2125 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009918515
251 https://doi.org/10.1038/nrm2125
252 rdf:type schema:CreativeWork
253 sg:pub.10.1038/sj.onc.1201869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050954779
254 https://doi.org/10.1038/sj.onc.1201869
255 rdf:type schema:CreativeWork
256 sg:pub.10.1111/1523-1747.ep12373187 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010172526
257 https://doi.org/10.1111/1523-1747.ep12373187
258 rdf:type schema:CreativeWork
259 sg:pub.10.1111/1523-1747.ep12461511 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023401430
260 https://doi.org/10.1111/1523-1747.ep12461511
261 rdf:type schema:CreativeWork
262 sg:pub.10.1111/1523-1747.ep12486833 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008612583
263 https://doi.org/10.1111/1523-1747.ep12486833
264 rdf:type schema:CreativeWork
265 https://app.dimensions.ai/details/publication/pub.1074703144 schema:CreativeWork
266 https://app.dimensions.ai/details/publication/pub.1081601702 schema:CreativeWork
267 https://app.dimensions.ai/details/publication/pub.1082576474 schema:CreativeWork
268 https://app.dimensions.ai/details/publication/pub.1083124322 schema:CreativeWork
269 https://app.dimensions.ai/details/publication/pub.1083214912 schema:CreativeWork
270 https://doi.org/10.1006/excr.1998.4049 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022062762
271 rdf:type schema:CreativeWork
272 https://doi.org/10.1016/s0002-9440(10)64582-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002097070
273 rdf:type schema:CreativeWork
274 https://doi.org/10.1016/s0065-230x(08)60028-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023925999
275 rdf:type schema:CreativeWork
276 https://doi.org/10.1016/s0092-8674(00)00139-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041975732
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1016/s0092-8674(00)81390-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041505425
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1016/s0092-8674(00)81768-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003077947
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1021/bi00146a017 schema:sameAs https://app.dimensions.ai/details/publication/pub.1055162573
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1021/jm970494j schema:sameAs https://app.dimensions.ai/details/publication/pub.1055958422
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1038/sj.emboj.7601173 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049190342
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1055/s-0038-1656074 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083102807
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1055/s-2007-996099 schema:sameAs https://app.dimensions.ai/details/publication/pub.1057522312
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1073/pnas.0402784101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010733726
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1073/pnas.84.16.5788 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031558531
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1073/pnas.93.12.5899 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032569991
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1073/pnas.96.26.15143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043150703
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1084/jem.20010815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027728020
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1093/emboj/18.17.4645 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027076933
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1101/gad.9.7.794 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022359688
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1111/j.1365-2141.1976.tb00953.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1032580515
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1111/j.1538-7836.2006.01861.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042869323
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1111/j.1699-0463.1999.tb01534.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1048953000
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1160/th04-11-0724 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063290345
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1161/01.atv.18.7.1035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004214594
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1172/jci116719 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015082624
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1182/blood.v97.12.3691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000534900
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1242/dev.00642 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037017051
321 rdf:type schema:CreativeWork
322 https://www.grid.ac/institutes/grid.5254.6 schema:alternateName University of Copenhagen
323 schema:name Institute of Molecular Biology, University of Copenhagen, Copenhagen Biocenter, Denmark
324 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...