Blood pressure control status and effects of pravastatin on cardiovascular events occurrence in patients with dyslipidaemia View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-05-19

AUTHORS

T Kushiro, K Mizuno, N Nakaya, Y Ohashi, T Teramoto, S Yokoyama, S Kakinoki, H Nakamura

ABSTRACT

Dyslipidaemia is often associated with hypertension, and many clinical trials have shown that lipid-lowering therapy and strict blood pressure (BP) control are important for preventing cardiovascular disease (CVD). However, few reports describe the effect of statins on CVD occurrence in relation to long-term BP control. In the present analysis, we investigated the effects of baseline BP and follow-up BP control on the occurrence of CVD in patients enrolled in the MEGA Study. We investigated whether BP values provide more accurate prediction of the occurrence of CVD, including cerebrovascular disease/transischemic attack (CVA/TIA), and the effect of pravastatin on CVA/TIA. The risk for CVA/TIA and other CVD increased significantly (P⩽0.001) as the severity of hypertension increased. In contrast, pravastatin reduced the onset of CVA/TIA, regardless of the BP controlled. The mean BP was a more accurate predictor of CVD than a one-time BP value. In patients with mild-to-moderate dyslipidaemia, elevated BP increases the risk for CVA/TIA and other CVD, and rigorous BP control was important for preventing CVD, in particular CVA/TIA. The 12-month mean BP is useful to avoid attenuation to determine the association between CVD and BP. Pravastatin prevented CVA/TIA, regardless of BP controlled. More... »

PAGES

388-395

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URI

http://scigraph.springernature.com/pub.10.1038/jhh.2011.49

DOI

http://dx.doi.org/10.1038/jhh.2011.49

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1023450113

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21593784


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