A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-04-13

AUTHORS

Izumi Naka, Takuro Furusawa, Ryosuke Kimura, Kazumi Natsuhara, Taro Yamauchi, Minato Nakazawa, Yuji Ataka, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Ryutaro Ohtsuka, Jun Ohashi

ABSTRACT

It has been suggested that a ‘thrifty’ genotype hypothesis can account for high prevalence of obesity in the island populations of Oceania. A recent genome-wide association study revealed that a missense variant, rs373863828-A (p.Arg457Gln), of the CREBRF gene (encoding CREB3 regulatory factor) was associated with an excessive increase in body mass index (BMI) in Samoans. In the present study, the association of rs373863828-A with an increase in BMI was examined in four Austronesian (AN)-speaking populations in Oceania. We found that rs373863828-A was frequently observed (frequency of 0.15) in Tongans (Polynesians), and was strongly associated with higher BMI (P=6.1 × 10−4). A single copy of the rs373863828-A allele increased BMI by 3.09 kg m−2 after adjustment of age and sex. No significant association was detected in the other three AN-speaking populations (Melanesians and Micronesians) living in Solomon Islands. This was probably due to the low allele frequency (0.02–0.06) of rs373863828-A as well as small sample size. The rs373863828-A allele was not found in both AN-speaking and non-AN-speaking Melanesians living in Papua New Guinea. Our results suggest that rs373863828-A of CREBRF, a promising thrifty variant, arose in recent ancestors of AN-speaking Polynesians. More... »

PAGES

847-849

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2017.44

DOI

http://dx.doi.org/10.1038/jhg.2017.44

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1084813816

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/28405013


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