Ontology type: schema:ScholarlyArticle
2015-11
AUTHORSHiroshi Furukawa, Shomi Oka, Kota Shimada, Atsushi Hashimoto, Shigeto Tohma
ABSTRACTHuman leukocyte antigen (HLA) polymorphisms are the most important genetic risk factors for rheumatoid arthritis (RA), a chronic systemic inflammatory disease of unknown etiology. Certain HLA-DRB1 alleles, known as shared epitope (SE) alleles because they have the same amino-acid sequence at positions 70-74, are associated with susceptibility to RA. A gene dosage effect is present for RA-predisposing SE alleles, and protective alleles show epistasis. An important role of amino-acid polymorphisms at positions 11 and 13 of the HLA-DRβ chain was also reported recently. Rheumatoid factor and anticitrullinated peptide antibodies are present in many RA patients. Similar to extra-articular manifestations, the presence of these autoantibodies is also associated with certain DRB1 alleles. Different frequencies of RA risk alleles in different ethnicities explain the varying prevalence of RA in different populations and suggest genetic heterogeneity of RA with regard to phenotype and population subsets. Some drug-induced hypersensitivity reactions due to disease-modifying antirheumatic drugs are also associated with HLA alleles. Understanding the role of HLA as the most important genetic factor relevant to RA susceptibility may help in determining its pathogenesis and pave the way to personalized medicine. More... »
PAGES691-696
http://scigraph.springernature.com/pub.10.1038/jhg.2015.36
DOIhttp://dx.doi.org/10.1038/jhg.2015.36
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1026968925
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/25903069
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antirheumatic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Arthritis, Rheumatoid",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Hypersensitivity",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "HLA Antigens",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Genetic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Precision Medicine",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."
],
"type": "Organization"
},
"familyName": "Furukawa",
"givenName": "Hiroshi",
"id": "sg:person.0671504703.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671504703.22"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."
],
"type": "Organization"
},
"familyName": "Oka",
"givenName": "Shomi",
"id": "sg:person.0762520143.42",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0762520143.42"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Tokyo Metropolitan Tama Medical Center",
"id": "https://www.grid.ac/institutes/grid.417089.3",
"name": [
"Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan.",
"Department of Rheumatic Diseases, Tokyo Metropolitan Tama Medical Center, Fuchu, Japan."
],
"type": "Organization"
},
"familyName": "Shimada",
"givenName": "Kota",
"id": "sg:person.01354476706.59",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01354476706.59"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Department of Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."
],
"type": "Organization"
},
"familyName": "Hashimoto",
"givenName": "Atsushi",
"id": "sg:person.0751535050.21",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0751535050.21"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Clinical Research Center for Allergy and Rheumatology, Sagamihara Hospital, National Hospital Organization, Sagamihara, Japan."
],
"type": "Organization"
},
"familyName": "Tohma",
"givenName": "Shigeto",
"id": "sg:person.0673140023.24",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0673140023.24"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1016/j.autrev.2013.08.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000075672"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0033133",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001187330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/ker010",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001357017"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.autrev.2004.09.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1002009042"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.20553",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003081261"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3899/jrheum.090303",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003381464"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/ard.2009.126821",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004460005"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3389/fimmu.2013.00321",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005118654"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/annrheumdis-2013-204591",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1005225298"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jaci.2011.12.990",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006059638"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.autrev.2011.10.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1006693168"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/15569520802696250",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007168339"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ki.1986.32",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007974489",
"https://doi.org/10.1038/ki.1986.32"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008027986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24410",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008027986"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.21302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008672515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.21302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008672515"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci115814",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008812974"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.1780300302",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008940859"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(02)07873-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009079366"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/kep052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009197188"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/kep052",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009197188"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0053910",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009251322"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0040067",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009870735"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.379",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010166549",
"https://doi.org/10.1038/ng.379"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.379",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010166549",
"https://doi.org/10.1038/ng.379"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/428486a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011673480",
"https://doi.org/10.1038/428486a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/428486a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011673480",
"https://doi.org/10.1038/428486a"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/428486a",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011673480",
"https://doi.org/10.1038/428486a"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0710260104",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011790232"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012076341"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012076341"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.rmed.2012.07.006",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012292152"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/03009749850154447",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1012702506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.20608",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013388795"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/ar1837",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1013434520",
"https://doi.org/10.1186/ar1837"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/44853",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014369434",
"https://doi.org/10.1038/44853"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/44853",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1014369434",
"https://doi.org/10.1038/44853"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddq537",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016007565"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/hmg/ddu387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1016828331"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4168/aair.2010.2.2.123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017791384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4168/aair.2010.2.2.123",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017791384"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/a:1005585515826",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018880153",
"https://doi.org/10.1023/a:1005585515826"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(87)91548-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020622606"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(87)91548-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020622606"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(10)60826-4",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020865753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.38855",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020873715"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10067-010-1454-y",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021036056",
"https://doi.org/10.1007/s10067-010-1454-y"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/kes427",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021456644"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.1780230315",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021626007"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/368711a0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021670380",
"https://doi.org/10.1038/368711a0"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature11147",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1021732479",
"https://doi.org/10.1038/nature11147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.296.6629.1083",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022641442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/rheumatology/36.4.440",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023222257"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/acr.20662",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027223757"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1529-0131(200008)43:8<1831::aid-anr19>3.0.co;2-6",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028228677"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/bor.0b013e328336ba63",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028248197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/bor.0b013e328336ba63",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028248197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/bor.0b013e328336ba63",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028248197"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1371/journal.pone.0099453",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029528924"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10157-003-0252-0",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030016732",
"https://doi.org/10.1007/s10157-003-0252-0"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/1529-0131(200001)43:1<30::aid-anr5>3.0.co;2-b",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030615882"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.20989",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030659969"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nrrheum.2012.237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1031018814",
"https://doi.org/10.1038/nrrheum.2012.237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.crohns.2011.03.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032259391"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.20693",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032311032"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.smim.2011.01.014",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1032318804"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/acr.21671",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033237810"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0198-8859(91)90117-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033884384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0198-8859(91)90117-r",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033884384"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/ard.2007.084897",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034761780"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.tpj.6500442",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1036027149",
"https://doi.org/10.1038/sj.tpj.6500442"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.pupt.2011.01.016",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037419725"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.27366",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037683830"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4137/bmi.s13654",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038320254"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10165-010-0280-z",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040445199",
"https://doi.org/10.1007/s10165-010-0280-z"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.23166",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041032363"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.autrev.2011.04.021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041171273"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/bmj.295.6601.745",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041485271"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041534036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24385",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041534036"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.1401105111",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042061350"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.1780350306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042461454"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/archopht.1997.01100150552021",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042626242"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature12873",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043116196",
"https://doi.org/10.1038/nature12873"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ajhg.2014.02.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043956688"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ng.1076",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044436764",
"https://doi.org/10.1038/ng.1076"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2337/db07-1331",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047004394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.1780301102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048639016"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1013297",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049630214"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0140-6736(02)08158-8",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049978024"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0016-5085(99)70404-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050572362"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci108382",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052024347"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/qjmed/89.11.821",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052119097"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3899/jrheum.140533",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052541652"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1080/030097498440769",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052915227"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1073/pnas.0409500102",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053208011"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24572",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053211337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/art.24572",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053211337"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/annrheumdis-2012-201944",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1053613782"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1086/516736",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1058790574"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.3899/jrheum.130270",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1071543193"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-123-3-199508010-00004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073699809"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.7326/0003-4819-124-5-199603010-00005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1073700387"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1075124854",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1076796808",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1078780424",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1079571419",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/014107688007300811",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081572948"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1177/014107688007300811",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1081572948"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1081734828",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082570895",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1082978258",
"type": "CreativeWork"
}
],
"datePublished": "2015-11",
"datePublishedReg": "2015-11-01",
"description": "Human leukocyte antigen (HLA) polymorphisms are the most important genetic risk factors for rheumatoid arthritis (RA), a chronic systemic inflammatory disease of unknown etiology. Certain HLA-DRB1 alleles, known as shared epitope (SE) alleles because they have the same amino-acid sequence at positions 70-74, are associated with susceptibility to RA. A gene dosage effect is present for RA-predisposing SE alleles, and protective alleles show epistasis. An important role of amino-acid polymorphisms at positions 11 and 13 of the HLA-DR\u03b2 chain was also reported recently. Rheumatoid factor and anticitrullinated peptide antibodies are present in many RA patients. Similar to extra-articular manifestations, the presence of these autoantibodies is also associated with certain DRB1 alleles. Different frequencies of RA risk alleles in different ethnicities explain the varying prevalence of RA in different populations and suggest genetic heterogeneity of RA with regard to phenotype and population subsets. Some drug-induced hypersensitivity reactions due to disease-modifying antirheumatic drugs are also associated with HLA alleles. Understanding the role of HLA as the most important genetic factor relevant to RA susceptibility may help in determining its pathogenesis and pave the way to personalized medicine. ",
"genre": "research_article",
"id": "sg:pub.10.1038/jhg.2015.36",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.6144190",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6105441",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6043347",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1294984",
"issn": [
"1434-5161",
"1435-232X"
],
"name": "Journal of Human Genetics",
"type": "Periodical"
},
{
"issueNumber": "11",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "60"
}
],
"name": "Human leukocyte antigen polymorphisms and personalized medicine for rheumatoid arthritis",
"pagination": "691-696",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"80794796c95feb2eac3284353634f7f3752ead6f5b2360bacaee2725b1f0b6b6"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"25903069"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"9808008"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/jhg.2015.36"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1026968925"
]
}
],
"sameAs": [
"https://doi.org/10.1038/jhg.2015.36",
"https://app.dimensions.ai/details/publication/pub.1026968925"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T14:47",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000424.jsonl",
"type": "ScholarlyArticle",
"url": "http://www.nature.com/jhg/journal/v60/n11/full/jhg201536a.html"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jhg.2015.36'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jhg.2015.36'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jhg.2015.36'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jhg.2015.36'
This table displays all metadata directly associated to this object as RDF triples.
443 TRIPLES
21 PREDICATES
134 URIs
29 LITERALS
17 BLANK NODES