A novel mutation in EED associated with overgrowth View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-06

AUTHORS

Ana S A Cohen, Beyhan Tuysuz, Yaoqing Shen, Sanjiv K Bhalla, Steven J M Jones, William T Gibson

ABSTRACT

In a patient suspected clinically to have Weaver syndrome, we ruled out mutations in EZH2 and NSD1, then identified a previously undescribed de novo mutation in EZH2's partner protein EED. Both proteins are members of the Polycomb Repressive Complex 2 that maintains gene silencing. On the basis of the similarities of the patient's phenotype to Weaver syndrome, which is caused by de novo mutations in EZH2, and on other lines of evidence including mouse Eed hypomorphs, we characterize this mutation as probably pathogenic for a Weaver-like overgrowth syndrome. This is the first report of overgrowth and related phenotypes associated with a constitutional mutation in human EED. More... »

PAGES

339-342

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2015.26

DOI

http://dx.doi.org/10.1038/jhg.2015.26

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005449335

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25787343


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