A functional SNP in FLT1 increases risk of coronary artery disease in a Japanese population View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-05

AUTHORS

Atsuko Konta, Kouichi Ozaki, Yasuhiko Sakata, Atsushi Takahashi, Takashi Morizono, Shinichiro Suna, Yoshihiro Onouchi, Tatsuhiko Tsunoda, Michiaki Kubo, Issei Komuro, Yoshinobu Eishi, Toshihiro Tanaka

ABSTRACT

Coronary artery disease (CAD) including myocardial infarction is one of the leading causes of death in many countries. Similar to other common diseases, its pathogenesis is thought to result from complex interactions among multiple genetic and environmental factors. Recent large-scale genetic association analysis for CAD identified 15 new loci. We examined the reproducibility of these previous association findings with 7990 cases and 6582 controls in a Japanese population. We found a convincing association of rs9319428 in FLT1, encoding fms-related tyrosine kinase 1 (P=5.98 × 10(-8)). Fine mapping using tag single-nucleotide polymorphisms (SNPs) at FLT1 locus revealed that another SNP (rs74412485) showed more profound genetic effect for CAD (P=2.85 × 10(-12)). The SNP, located in intron 1 in FLT1, enhanced the transcriptional level of FLT1. RNA interference experiment against FLT1 showed that the suppression of FLT1 resulted in decreased expression of inflammatory adhesion molecules. Expression of FLT1 was observed in endothelial cells of human coronary artery. Our results indicate that the genetically coded increased expression of FLT1 by a functional SNP implicates activation in an inflammatory cascade that might eventually lead to CAD. More... »

PAGES

435-441

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2015.171

DOI

http://dx.doi.org/10.1038/jhg.2015.171

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043817367

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26791355


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