Influence of the NRGN gene on intellectual ability in schizophrenia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-08-01

AUTHORS

Kazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Motoyuki Fukumoto, Hidenaga Yamamori, Satomi Umeda-Yano, Michiko Fujimoto, Masao Iwase, Hiroaki Kazui, Masatoshi Takeda

ABSTRACT

Genome-wide association studies have reported an association between schizophrenia and rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809–rs12278912 haplotype of the gene is associated with schizophrenia in a Japanese population and that the NRGN expression of the high-risk TG haplotype is lower than that of the protective TA haplotype in immortalized lymphoblasts. In this study, we investigated the influences of neurogranin genotypes (rs12807809 and rs12278912), haplotypes and diplotypes and genetic variant–diagnosis interactions on intellectual ability in 414 Japanese patients with schizophrenia and healthy subjects. We detected possible effects of the genome-wide screen-supported rs12807809, haplotypes, diplotypes and their genetic variant–diagnosis interactions on intellectual abilities at the threshold level of P<0.05. After applying Bonferroni correction for 13 genotype measures and setting P-values for significance (P<0.0039; 0.05/13), three effects remained significant: the rs12807809–rs12278912 diplotype–diagnosis interactions on performance intelligence quotient (CG/CG: P=3.9 × 10−13; TA/TA: P=1.1 × 10−7) and TA/TA diplotype on performance intelligence quotient in patients with schizophrenia (P=8.2 × 10−8) remained significant. The intellectual abilities of the high-risk TG/TG diplotype of the neurogranin gene were lower compared to those with the non-risk TA/TA diplotype. Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability. More... »

PAGES

700-705

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2013.82

DOI

http://dx.doi.org/10.1038/jhg.2013.82

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1031138338

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23903071


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34 schema:description Genome-wide association studies have reported an association between schizophrenia and rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809–rs12278912 haplotype of the gene is associated with schizophrenia in a Japanese population and that the NRGN expression of the high-risk TG haplotype is lower than that of the protective TA haplotype in immortalized lymphoblasts. In this study, we investigated the influences of neurogranin genotypes (rs12807809 and rs12278912), haplotypes and diplotypes and genetic variant–diagnosis interactions on intellectual ability in 414 Japanese patients with schizophrenia and healthy subjects. We detected possible effects of the genome-wide screen-supported rs12807809, haplotypes, diplotypes and their genetic variant–diagnosis interactions on intellectual abilities at the threshold level of P<0.05. After applying Bonferroni correction for 13 genotype measures and setting P-values for significance (P<0.0039; 0.05/13), three effects remained significant: the rs12807809–rs12278912 diplotype–diagnosis interactions on performance intelligence quotient (CG/CG: P=3.9 × 10−13; TA/TA: P=1.1 × 10−7) and TA/TA diplotype on performance intelligence quotient in patients with schizophrenia (P=8.2 × 10−8) remained significant. The intellectual abilities of the high-risk TG/TG diplotype of the neurogranin gene were lower compared to those with the non-risk TA/TA diplotype. Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability.
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41 Japanese patients
42 Japanese population
43 NRGN expression
44 NRGN gene
45 TA haplotype
46 TG haplotype
47 ability
48 association
49 association studies
50 correction
51 diplotypes
52 effect
53 expression
54 findings
55 genes
56 genetic risk variants
57 genome-wide association studies
58 genotype measures
59 genotypes
60 haplotypes
61 healthy subjects
62 immortalized lymphoblasts
63 influence
64 intellectual ability
65 intelligence quotient
66 interaction
67 levels
68 lymphoblasts
69 measures
70 neurogranin gene
71 p-value
72 patients
73 performance intelligence quotient
74 population
75 possible effects
76 quotient
77 risk variants
78 rs12807809
79 schizophrenia
80 significance
81 study
82 subjects
83 threshold level
84 variants
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