Ontology type: schema:ScholarlyArticle Open Access: True
2013-08-01
AUTHORSKazutaka Ohi, Ryota Hashimoto, Yuka Yasuda, Motoyuki Fukumoto, Hidenaga Yamamori, Satomi Umeda-Yano, Michiko Fujimoto, Masao Iwase, Hiroaki Kazui, Masatoshi Takeda
ABSTRACTGenome-wide association studies have reported an association between schizophrenia and rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809–rs12278912 haplotype of the gene is associated with schizophrenia in a Japanese population and that the NRGN expression of the high-risk TG haplotype is lower than that of the protective TA haplotype in immortalized lymphoblasts. In this study, we investigated the influences of neurogranin genotypes (rs12807809 and rs12278912), haplotypes and diplotypes and genetic variant–diagnosis interactions on intellectual ability in 414 Japanese patients with schizophrenia and healthy subjects. We detected possible effects of the genome-wide screen-supported rs12807809, haplotypes, diplotypes and their genetic variant–diagnosis interactions on intellectual abilities at the threshold level of P<0.05. After applying Bonferroni correction for 13 genotype measures and setting P-values for significance (P<0.0039; 0.05/13), three effects remained significant: the rs12807809–rs12278912 diplotype–diagnosis interactions on performance intelligence quotient (CG/CG: P=3.9 × 10−13; TA/TA: P=1.1 × 10−7) and TA/TA diplotype on performance intelligence quotient in patients with schizophrenia (P=8.2 × 10−8) remained significant. The intellectual abilities of the high-risk TG/TG diplotype of the neurogranin gene were lower compared to those with the non-risk TA/TA diplotype. Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability. More... »
PAGES700-705
http://scigraph.springernature.com/pub.10.1038/jhg.2013.82
DOIhttp://dx.doi.org/10.1038/jhg.2013.82
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1031138338
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/23903071
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Genetics",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Clinical Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Alleles",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Asians",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Case-Control Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genetic Predisposition to Disease",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Genome-Wide Association Study",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Haplotypes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intellectual Disability",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Intelligence",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neurogranin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Polymorphism, Single Nucleotide",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Regression Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Risk Factors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Schizophrenia",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Young Adult",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "National Hospital Organization, Yamato Mental-Medical Center, Nara, Japan",
"id": "http://www.grid.ac/institutes/grid.416698.4",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan",
"National Hospital Organization, Yamato Mental-Medical Center, Nara, Japan"
],
"type": "Organization"
},
"familyName": "Ohi",
"givenName": "Kazutaka",
"id": "sg:person.0636562453.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0636562453.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Molecular Research Center for Children\u2019s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University, Chiba University and Fukui University School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan",
"Molecular Research Center for Children\u2019s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University, Chiba University and Fukui University School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Hashimoto",
"givenName": "Ryota",
"id": "sg:person.01172504713.23",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01172504713.23"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Yasuda",
"givenName": "Yuka",
"id": "sg:person.01314053353.40",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01314053353.40"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan",
"id": "http://www.grid.ac/institutes/grid.419082.6",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan"
],
"type": "Organization"
},
"familyName": "Fukumoto",
"givenName": "Motoyuki",
"id": "sg:person.01306733313.03",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01306733313.03"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Core Research for Evolutionary Science and Technology (CREST) of Japan Science and Technology Agency (JST), Saitama, Japan",
"Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Yamamori",
"givenName": "Hidenaga",
"id": "sg:person.01251601253.15",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251601253.15"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Molecular Neuropsychiatry, Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Umeda-Yano",
"givenName": "Satomi",
"id": "sg:person.01256642147.91",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01256642147.91"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Fujimoto",
"givenName": "Michiko",
"id": "sg:person.01003427310.39",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003427310.39"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Iwase",
"givenName": "Masao",
"id": "sg:person.010013272672.50",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010013272672.50"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Kazui",
"givenName": "Hiroaki",
"id": "sg:person.01207327153.52",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01207327153.52"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Molecular Research Center for Children\u2019s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University, Chiba University and Fukui University School of Medicine, Osaka, Japan",
"id": "http://www.grid.ac/institutes/grid.136593.b",
"name": [
"Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan",
"Molecular Research Center for Children\u2019s Mental Development, United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University, Chiba University and Fukui University School of Medicine, Osaka, Japan"
],
"type": "Organization"
},
"familyName": "Takeda",
"givenName": "Masatoshi",
"id": "sg:person.01275321421.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275321421.76"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1023/a:1013349512683",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047280922",
"https://doi.org/10.1023/a:1013349512683"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature08186",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044671852",
"https://doi.org/10.1038/nature08186"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.3758/bf03193146",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1024585197",
"https://doi.org/10.3758/bf03193146"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/mp.2011.66",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007532755",
"https://doi.org/10.1038/mp.2011.66"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.mp.4001982",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018626777",
"https://doi.org/10.1038/sj.mp.4001982"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/bf02354306",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034620291",
"https://doi.org/10.1007/bf02354306"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature10514",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1048007534",
"https://doi.org/10.1038/nature10514"
],
"type": "CreativeWork"
}
],
"datePublished": "2013-08-01",
"datePublishedReg": "2013-08-01",
"description": "Genome-wide association studies have reported an association between schizophrenia and rs12807809 of the neurogranin (NRGN) gene. We have recently found that an rs12807809\u2013rs12278912 haplotype of the gene is associated with schizophrenia in a Japanese population and that the NRGN expression of the high-risk TG haplotype is lower than that of the protective TA haplotype in immortalized lymphoblasts. In this study, we investigated the influences of neurogranin genotypes (rs12807809 and rs12278912), haplotypes and diplotypes and genetic variant\u2013diagnosis interactions on intellectual ability in 414 Japanese patients with schizophrenia and healthy subjects. We detected possible effects of the genome-wide screen-supported rs12807809, haplotypes, diplotypes and their genetic variant\u2013diagnosis interactions on intellectual abilities at the threshold level of P<0.05. After applying Bonferroni correction for 13 genotype measures and setting P-values for significance (P<0.0039; 0.05/13), three effects remained significant: the rs12807809\u2013rs12278912 diplotype\u2013diagnosis interactions on performance intelligence quotient (CG/CG: P=3.9 \u00d7 10\u221213; TA/TA: P=1.1 \u00d7 10\u22127) and TA/TA diplotype on performance intelligence quotient in patients with schizophrenia (P=8.2 \u00d7 10\u22128) remained significant. The intellectual abilities of the high-risk TG/TG diplotype of the neurogranin gene were lower compared to those with the non-risk TA/TA diplotype. Our findings suggest that the genetic risk variant in the neurogranin gene may be related to reduced intellectual ability.",
"genre": "article",
"id": "sg:pub.10.1038/jhg.2013.82",
"isAccessibleForFree": true,
"isFundedItemOf": [
{
"id": "sg:grant.6130703",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6112186",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6111761",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6132708",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6086570",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6090133",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6039304",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6073431",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6119339",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1294984",
"issn": [
"1434-5161",
"1435-232X"
],
"name": "Journal of Human Genetics",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "10",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "58"
}
],
"keywords": [
"performance intelligence quotient",
"neurogranin gene",
"intelligence quotient",
"Japanese patients",
"healthy subjects",
"genetic risk variants",
"immortalized lymphoblasts",
"NRGN gene",
"TG haplotype",
"schizophrenia",
"TA haplotype",
"Japanese population",
"NRGN expression",
"Bonferroni correction",
"patients",
"risk variants",
"genotype measures",
"p-value",
"rs12807809",
"diplotypes",
"intellectual ability",
"genome-wide association studies",
"possible effects",
"association studies",
"haplotypes",
"genes",
"lymphoblasts",
"threshold level",
"study",
"association",
"subjects",
"effect",
"ability",
"population",
"expression",
"findings",
"quotient",
"genotypes",
"levels",
"significance",
"variants",
"measures",
"correction",
"interaction",
"influence"
],
"name": "Influence of the NRGN gene on intellectual ability in schizophrenia",
"pagination": "700-705",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1031138338"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1038/jhg.2013.82"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"23903071"
]
}
],
"sameAs": [
"https://doi.org/10.1038/jhg.2013.82",
"https://app.dimensions.ai/details/publication/pub.1031138338"
],
"sdDataset": "articles",
"sdDatePublished": "2022-08-04T17:01",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220804/entities/gbq_results/article/article_585.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1038/jhg.2013.82"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jhg.2013.82'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jhg.2013.82'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jhg.2013.82'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jhg.2013.82'
This table displays all metadata directly associated to this object as RDF triples.
313 TRIPLES
21 PREDICATES
98 URIs
81 LITERALS
26 BLANK NODES