Recapitulation of previous genome-wide association studies with two distinct pathophysiological entities of gastric cancer in the Korean population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

Joo-Yeon Hwang, Duk-Hwan Kim, Yong-Ick Ji, Min Jin Go, Lyong Heo, Young Jin Kim, Tae Sung Sohn, Jae Hyung Noh, Sung Kim, Yeon-Su Lee, Sook-Young Kim, Young-Woo Kim, Keun Won Ryu, Il Ju Choi, Juyoung Lee, Bong-Jo Kim, Bok-Ghee Han, Joobae Park, Jong-Young Lee

ABSTRACT

Gastric cancer (GC) is the most common malignancy. The incidence rates remain remarkably high in East Asians. Although genome-wide association studies in the Han Chinese and Japanese populations have so far yielded susceptibility loci for GC, these findings need to be validated in an independent ethnic group. To identify the potential heterogeneity by histological classified subtypes (intestinal and diffuse), we examined the previously reported associations in the Korean population. PRKAA1 at 5p13.1 was found to be more strongly associated with intestinal type (odds ratio, OR=1.39, 95% CI (confidence interval) =1.22-1.58, P=3.77 × 10(-7)) than diffuse type. In addition, PSCA at 8q23.3 was significantly replicated in diffuse type (OR=1.49, 95% CI=1.32-1.67, P=2.43 × 10(-11)) but far less significant in intestinal type. In conclusion, these findings could bring additional insights into the etiologic heterogeneity in gastric carcinogenesis mechanisms. More... »

PAGES

233

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2012.158

DOI

http://dx.doi.org/10.1038/jhg.2012.158

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026769381

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23389241


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