Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-17

AUTHORS

Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ricky Eddie, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Yuji Ataka, Ryutaro Ohtsuka, Jun Ohashi

ABSTRACT

Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa. This study aimed to reveal the frequencies of hypertension-susceptibility genotypes in Pacific Island populations and associations of these single-nucleotide polymorphisms (SNPs) to hypertension. Genotyping was conducted for 804 individuals from Melanesian, Micronesian and Polynesian populations at SNPs in the genes encoding AGT (rs699, rs5049 and rs5051), GNB3 (rs5443) and CYP3A5*1/*3 (rs776746). Associations between these SNPs and hypertension were tested for 383 Melanesian Solomon Islanders. We found that the A/A genotype at rs5049 was a risk factor for hypertension (P=0.025) in the Melanesian Solomon Islanders; three SNPs for AGT were in linkage disequilibrium. The ancestral alleles of rs699, rs5051 and rs776746, and the derived allele of rs5443 were as frequent in the populations surveyed here as in other equatorial populations. Although other polymorphisms associated with hypertension and additional populations remain to be studied, these findings suggest that the Pacific Islanders’ susceptibility to hypertension arose because of human migration and adaptation. More... »

PAGES

142-149

Journal

TITLE

Journal of Human Genetics

ISSUE

3

VOLUME

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2012.147

DOI

http://dx.doi.org/10.1038/jhg.2012.147

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003619200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23324949


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393 grid-institutes:grid.412339.e schema:alternateName Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
394 schema:name Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
395 rdf:type schema:Organization
396 grid-institutes:grid.442887.5 schema:alternateName Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan
397 schema:name Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan
398 rdf:type schema:Organization
399 grid-institutes:grid.472088.1 schema:alternateName The Japanese Red Cross Akita College of Nursing, Akita, Japan
400 schema:name The Japanese Red Cross Akita College of Nursing, Akita, Japan
401 rdf:type schema:Organization
 




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