Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-01-17

AUTHORS

Takuro Furusawa, Izumi Naka, Taro Yamauchi, Kazumi Natsuhara, Ricky Eddie, Ryosuke Kimura, Minato Nakazawa, Takafumi Ishida, Tsukasa Inaoka, Yasuhiro Matsumura, Yuji Ataka, Ryutaro Ohtsuka, Jun Ohashi

ABSTRACT

Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa. This study aimed to reveal the frequencies of hypertension-susceptibility genotypes in Pacific Island populations and associations of these single-nucleotide polymorphisms (SNPs) to hypertension. Genotyping was conducted for 804 individuals from Melanesian, Micronesian and Polynesian populations at SNPs in the genes encoding AGT (rs699, rs5049 and rs5051), GNB3 (rs5443) and CYP3A5*1/*3 (rs776746). Associations between these SNPs and hypertension were tested for 383 Melanesian Solomon Islanders. We found that the A/A genotype at rs5049 was a risk factor for hypertension (P=0.025) in the Melanesian Solomon Islanders; three SNPs for AGT were in linkage disequilibrium. The ancestral alleles of rs699, rs5051 and rs776746, and the derived allele of rs5443 were as frequent in the populations surveyed here as in other equatorial populations. Although other polymorphisms associated with hypertension and additional populations remain to be studied, these findings suggest that the Pacific Islanders’ susceptibility to hypertension arose because of human migration and adaptation. More... »

PAGES

142-149

Journal

TITLE

Journal of Human Genetics

ISSUE

3

VOLUME

58

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2012.147

DOI

http://dx.doi.org/10.1038/jhg.2012.147

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1003619200

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23324949


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0604", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Genetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adolescent", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Alleles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Angiotensinogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cytochrome P-450 CYP3A", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Association Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetics, Population", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Heterotrimeric GTP-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Human Migration", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hypertension", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Melanesia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pacific Islands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Graduate School of Asian and African Area Studies, Kyoto University, Kyoto, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258799.8", 
          "name": [
            "Graduate School of Asian and African Area Studies, Kyoto University, Kyoto, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Furusawa", 
        "givenName": "Takuro", 
        "id": "sg:person.01063541463.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063541463.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Naka", 
        "givenName": "Izumi", 
        "id": "sg:person.01270026746.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270026746.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan", 
          "id": "http://www.grid.ac/institutes/grid.39158.36", 
          "name": [
            "Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yamauchi", 
        "givenName": "Taro", 
        "id": "sg:person.011023124005.26", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011023124005.26"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The Japanese Red Cross Akita College of Nursing, Akita, Japan", 
          "id": "http://www.grid.ac/institutes/grid.472088.1", 
          "name": [
            "The Japanese Red Cross Akita College of Nursing, Akita, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Natsuhara", 
        "givenName": "Kazumi", 
        "id": "sg:person.01133427520.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133427520.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "National Gizo Hospital, Ministry of Health and Medical Services, Gizo, The Solomon Islands", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "National Gizo Hospital, Ministry of Health and Medical Services, Gizo, The Solomon Islands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eddie", 
        "givenName": "Ricky", 
        "id": "sg:person.0640500420.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640500420.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.267625.2", 
          "name": [
            "Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kimura", 
        "givenName": "Ryosuke", 
        "id": "sg:person.0624243455.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan", 
          "id": "http://www.grid.ac/institutes/grid.31432.37", 
          "name": [
            "Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nakazawa", 
        "givenName": "Minato", 
        "id": "sg:person.01006605255.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006605255.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.26999.3d", 
          "name": [
            "Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ishida", 
        "givenName": "Takafumi", 
        "id": "sg:person.015576331772.42", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan", 
          "id": "http://www.grid.ac/institutes/grid.412339.e", 
          "name": [
            "Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Inaoka", 
        "givenName": "Tsukasa", 
        "id": "sg:person.0705040763.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705040763.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan", 
          "id": "http://www.grid.ac/institutes/grid.442887.5", 
          "name": [
            "Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Matsumura", 
        "givenName": "Yasuhiro", 
        "id": "sg:person.013241054552.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241054552.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan", 
          "id": "http://www.grid.ac/institutes/grid.258777.8", 
          "name": [
            "School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ataka", 
        "givenName": "Yuji", 
        "id": "sg:person.01065141161.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065141161.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Japan Wildlife Research Center, Tokyo, Japan", 
          "id": "http://www.grid.ac/institutes/None", 
          "name": [
            "Japan Wildlife Research Center, Tokyo, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohtsuka", 
        "givenName": "Ryutaro", 
        "id": "sg:person.0674751503.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674751503.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan", 
          "id": "http://www.grid.ac/institutes/grid.20515.33", 
          "name": [
            "Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ohashi", 
        "givenName": "Jun", 
        "id": "sg:person.0646643507.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1007/s11906-007-0004-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004986735", 
          "https://doi.org/10.1007/s11906-007-0004-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10038-006-0375-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036387975", 
          "https://doi.org/10.1007/s10038-006-0375-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35065520", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047123449", 
          "https://doi.org/10.1038/35065520"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00109-003-0482-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011736456", 
          "https://doi.org/10.1007/s00109-003-0482-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ejhg.2010.179", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010315662", 
          "https://doi.org/10.1038/ejhg.2010.179"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng0198-45", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005273023", 
          "https://doi.org/10.1038/ng0198-45"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1016280427032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021186916", 
          "https://doi.org/10.1023/a:1016280427032"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/336307a0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032340039", 
          "https://doi.org/10.1038/336307a0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-009-0768-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031130180", 
          "https://doi.org/10.1007/s00439-009-0768-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.clpt.6100090", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027909521", 
          "https://doi.org/10.1038/sj.clpt.6100090"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1018727607651", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015262481", 
          "https://doi.org/10.1023/a:1018727607651"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10038-007-0198-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015898872", 
          "https://doi.org/10.1007/s10038-007-0198-2"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-01-17", 
    "datePublishedReg": "2013-01-17", 
    "description": "Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein \u03b23-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa. This study aimed to reveal the frequencies of hypertension-susceptibility genotypes in Pacific Island populations and associations of these single-nucleotide polymorphisms (SNPs) to hypertension. Genotyping was conducted for 804 individuals from Melanesian, Micronesian and Polynesian populations at SNPs in the genes encoding AGT (rs699, rs5049 and rs5051), GNB3 (rs5443) and CYP3A5*1/*3 (rs776746). Associations between these SNPs and hypertension were tested for 383 Melanesian Solomon Islanders. We found that the A/A genotype at rs5049 was a risk factor for hypertension (P=0.025) in the Melanesian Solomon Islanders; three SNPs for AGT were in linkage disequilibrium. The ancestral alleles of rs699, rs5051 and rs776746, and the derived allele of rs5443 were as frequent in the populations surveyed here as in other equatorial populations. Although other polymorphisms associated with hypertension and additional populations remain to be studied, these findings suggest that the Pacific Islanders\u2019 susceptibility to hypertension arose because of human migration and adaptation.", 
    "genre": "article", 
    "id": "sg:pub.10.1038/jhg.2012.147", 
    "inLanguage": "en", 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6012595", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6109600", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6040969", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6048793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6072810", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5794899", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6072082", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1294984", 
        "issn": [
          "1434-5161", 
          "1435-232X"
        ], 
        "name": "Journal of Human Genetics", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "58"
      }
    ], 
    "keywords": [
      "single-nucleotide polymorphisms", 
      "hypertension susceptibility genes", 
      "island populations", 
      "ancestral allele", 
      "equatorial populations", 
      "linkage disequilibrium", 
      "susceptibility genes", 
      "additional populations", 
      "genes", 
      "alleles", 
      "Polynesian population", 
      "climatic changes", 
      "human migration", 
      "Pacific Islands", 
      "gene prevalence", 
      "genetic factors", 
      "genotypes", 
      "Pacific Island populations", 
      "polymorphism", 
      "human adaptation", 
      "protein \u03b23-subunit", 
      "risk alleles", 
      "adaptation", 
      "loci", 
      "population", 
      "migration", 
      "\u03b23-subunit", 
      "disequilibrium", 
      "Solomon Islanders", 
      "islands", 
      "susceptibility", 
      "genotyping", 
      "GNB3", 
      "Melanesia", 
      "Melanesians", 
      "factors", 
      "association", 
      "human essential hypertension", 
      "rs5051", 
      "angiotensinogen", 
      "Africa", 
      "cytochrome P450 3A5", 
      "rs776746", 
      "changes", 
      "individuals", 
      "rs5443", 
      "findings", 
      "study", 
      "P450 3A5", 
      "frequency", 
      "rs699", 
      "CYP3A5", 
      "Islanders", 
      "prevalence", 
      "essential hypertension", 
      "hypertension", 
      "risk factors", 
      "candidate hypertension susceptibility genes", 
      "hypertension-susceptibility genotypes", 
      "Melanesian Solomon Islanders", 
      "rs5049", 
      "allele of rs5443", 
      "Pacific Islanders\u2019 susceptibility", 
      "Islanders\u2019 susceptibility", 
      "Hypertension-susceptibility gene prevalence"
    ], 
    "name": "Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia", 
    "pagination": "142-149", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1003619200"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1038/jhg.2012.147"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23324949"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1038/jhg.2012.147", 
      "https://app.dimensions.ai/details/publication/pub.1003619200"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2021-12-01T19:30", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20211201/entities/gbq_results/article/article_612.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1038/jhg.2012.147"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jhg.2012.147'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jhg.2012.147'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jhg.2012.147'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jhg.2012.147'


 

This table displays all metadata directly associated to this object as RDF triples.

401 TRIPLES      22 PREDICATES      127 URIs      107 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1038/jhg.2012.147 schema:about N08e6e9c143874c3d9ebee29dfa2bf1cb
2 N0fe7b1da931546d5990379a11c5bd86d
3 N412dd678aa5649f6bc304aeead4c380d
4 N41a9871862dc41a0bf1daa506bbd2ce3
5 N4620593f14fe44dcb1e33d2984edaf5e
6 N57fdf30940b444168cda173809ff427f
7 N5ff20b95180a4cc095c57d4a5ff8b1b9
8 N5ff889a56c534d5fb1f1e3b6c6f76f7d
9 N7019c578e628471b8440f01c2781b7cd
10 N75ffdcf78a8545dfa01764728a528ccd
11 N79432ebcd85d449bb2dc1cd59b8cb6ef
12 N79a0e936c4dc48cdb629492040319710
13 N9f2d7028e028407f8145167607854669
14 Na1244151e4e948c8baadbaee6c5ebe91
15 Nb1afe71ca66842a0a9f985d7a05c2db4
16 Nc45a4c5851f5449293227e770f8b504a
17 Nc72874be6aec42b7989d6a01b7521c5c
18 Ncbaa95e0923044a8abb266e25e48e45a
19 Nd78247c958e14e3c8995926102802ec0
20 Ndee7491ceb714caf82ac7463a5086728
21 Ne60e97954db64323aae571db62966e44
22 Ne968a4af837a465d9741ed471d18ceb7
23 Neeebcf5d38514591ae6a9de1f646c501
24 Nfda0bb60c6b84549a3c8e7414cf3eea4
25 anzsrc-for:06
26 anzsrc-for:0604
27 schema:author Nb728f2e163374d779656b127b6d37ecf
28 schema:citation sg:pub.10.1007/s00109-003-0482-3
29 sg:pub.10.1007/s00439-009-0768-9
30 sg:pub.10.1007/s10038-006-0375-8
31 sg:pub.10.1007/s10038-007-0198-2
32 sg:pub.10.1007/s11906-007-0004-8
33 sg:pub.10.1023/a:1016280427032
34 sg:pub.10.1023/a:1018727607651
35 sg:pub.10.1038/336307a0
36 sg:pub.10.1038/35065520
37 sg:pub.10.1038/ejhg.2010.179
38 sg:pub.10.1038/ng0198-45
39 sg:pub.10.1038/sj.clpt.6100090
40 schema:datePublished 2013-01-17
41 schema:datePublishedReg 2013-01-17
42 schema:description Human essential hypertension is partly caused by genetic factors. Angiotensinogen (AGT), G-protein β3-subunit (GNB3) and cytochrome P450 3A5 (CYP3A5) are candidate hypertension susceptibility genes and risk alleles at these loci have been thought to arise owing to human adaptation to climatic changes following the migration out-of-Africa. This study aimed to reveal the frequencies of hypertension-susceptibility genotypes in Pacific Island populations and associations of these single-nucleotide polymorphisms (SNPs) to hypertension. Genotyping was conducted for 804 individuals from Melanesian, Micronesian and Polynesian populations at SNPs in the genes encoding AGT (rs699, rs5049 and rs5051), GNB3 (rs5443) and CYP3A5*1/*3 (rs776746). Associations between these SNPs and hypertension were tested for 383 Melanesian Solomon Islanders. We found that the A/A genotype at rs5049 was a risk factor for hypertension (P=0.025) in the Melanesian Solomon Islanders; three SNPs for AGT were in linkage disequilibrium. The ancestral alleles of rs699, rs5051 and rs776746, and the derived allele of rs5443 were as frequent in the populations surveyed here as in other equatorial populations. Although other polymorphisms associated with hypertension and additional populations remain to be studied, these findings suggest that the Pacific Islanders’ susceptibility to hypertension arose because of human migration and adaptation.
43 schema:genre article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N79a354ded0434fde8c9fca975dc664ec
47 Nc4c0abf2f87747b8996c7b10762999a9
48 sg:journal.1294984
49 schema:keywords Africa
50 CYP3A5
51 GNB3
52 Hypertension-susceptibility gene prevalence
53 Islanders
54 Islanders’ susceptibility
55 Melanesia
56 Melanesian Solomon Islanders
57 Melanesians
58 P450 3A5
59 Pacific Island populations
60 Pacific Islanders’ susceptibility
61 Pacific Islands
62 Polynesian population
63 Solomon Islanders
64 adaptation
65 additional populations
66 allele of rs5443
67 alleles
68 ancestral allele
69 angiotensinogen
70 association
71 candidate hypertension susceptibility genes
72 changes
73 climatic changes
74 cytochrome P450 3A5
75 disequilibrium
76 equatorial populations
77 essential hypertension
78 factors
79 findings
80 frequency
81 gene prevalence
82 genes
83 genetic factors
84 genotypes
85 genotyping
86 human adaptation
87 human essential hypertension
88 human migration
89 hypertension
90 hypertension susceptibility genes
91 hypertension-susceptibility genotypes
92 individuals
93 island populations
94 islands
95 linkage disequilibrium
96 loci
97 migration
98 polymorphism
99 population
100 prevalence
101 protein β3-subunit
102 risk alleles
103 risk factors
104 rs5049
105 rs5051
106 rs5443
107 rs699
108 rs776746
109 single-nucleotide polymorphisms
110 study
111 susceptibility
112 susceptibility genes
113 β3-subunit
114 schema:name Hypertension-susceptibility gene prevalence in the Pacific Islands and associations with hypertension in Melanesia
115 schema:pagination 142-149
116 schema:productId N4b59a320f3654019878900862f473a1a
117 N8eea8bed9b4b47bdb7a36b98e7e753b7
118 Nf4c3dca22d804033ba7877857782619f
119 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003619200
120 https://doi.org/10.1038/jhg.2012.147
121 schema:sdDatePublished 2021-12-01T19:30
122 schema:sdLicense https://scigraph.springernature.com/explorer/license/
123 schema:sdPublisher N63b0872ea70343d58242ba1c1a510c0a
124 schema:url https://doi.org/10.1038/jhg.2012.147
125 sgo:license sg:explorer/license/
126 sgo:sdDataset articles
127 rdf:type schema:ScholarlyArticle
128 N08e6e9c143874c3d9ebee29dfa2bf1cb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Cytochrome P-450 CYP3A
130 rdf:type schema:DefinedTerm
131 N0fe7b1da931546d5990379a11c5bd86d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
132 schema:name Female
133 rdf:type schema:DefinedTerm
134 N13da7bfd9bc747329021850291d07bec rdf:first sg:person.01133427520.40
135 rdf:rest Nd6e5786c7b5c4fa0a2d5c43dced3044d
136 N3eaeda1a3c1d469fb616be659bcb24fe rdf:first sg:person.01006605255.48
137 rdf:rest Ne2b4656bdd4e4afc86ad135b5952438b
138 N412dd678aa5649f6bc304aeead4c380d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Young Adult
140 rdf:type schema:DefinedTerm
141 N41a9871862dc41a0bf1daa506bbd2ce3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Humans
143 rdf:type schema:DefinedTerm
144 N4620593f14fe44dcb1e33d2984edaf5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Adolescent
146 rdf:type schema:DefinedTerm
147 N4b59a320f3654019878900862f473a1a schema:name doi
148 schema:value 10.1038/jhg.2012.147
149 rdf:type schema:PropertyValue
150 N4f898288f46d49c6910d65b1dc8f180a rdf:first sg:person.01270026746.37
151 rdf:rest Na48cb3b3c8bc4024bf990604054917ae
152 N57fdf30940b444168cda173809ff427f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Human Migration
154 rdf:type schema:DefinedTerm
155 N5b1d55d215904d03adfc7d2aa3d21c38 rdf:first sg:person.01065141161.63
156 rdf:rest N6a4c9bfbe66744bc947c2c6fa4616d9a
157 N5ff20b95180a4cc095c57d4a5ff8b1b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Middle Aged
159 rdf:type schema:DefinedTerm
160 N5ff889a56c534d5fb1f1e3b6c6f76f7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Adult
162 rdf:type schema:DefinedTerm
163 N63b0872ea70343d58242ba1c1a510c0a schema:name Springer Nature - SN SciGraph project
164 rdf:type schema:Organization
165 N6a4c9bfbe66744bc947c2c6fa4616d9a rdf:first sg:person.0674751503.28
166 rdf:rest Nba3988c9e62f461e800a81a3d3ea9eaa
167 N6ebf68e22f884a359e135f95d1e1eb93 rdf:first sg:person.013241054552.08
168 rdf:rest N5b1d55d215904d03adfc7d2aa3d21c38
169 N7019c578e628471b8440f01c2781b7cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Risk Factors
171 rdf:type schema:DefinedTerm
172 N75ffdcf78a8545dfa01764728a528ccd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Gene Frequency
174 rdf:type schema:DefinedTerm
175 N79432ebcd85d449bb2dc1cd59b8cb6ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Prevalence
177 rdf:type schema:DefinedTerm
178 N79a0e936c4dc48cdb629492040319710 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Heterotrimeric GTP-Binding Proteins
180 rdf:type schema:DefinedTerm
181 N79a354ded0434fde8c9fca975dc664ec schema:issueNumber 3
182 rdf:type schema:PublicationIssue
183 N8eea8bed9b4b47bdb7a36b98e7e753b7 schema:name pubmed_id
184 schema:value 23324949
185 rdf:type schema:PropertyValue
186 N9f2d7028e028407f8145167607854669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
187 schema:name Alleles
188 rdf:type schema:DefinedTerm
189 Na08d72eb95d04efebdcb14f0a1e61afd rdf:first sg:person.0705040763.44
190 rdf:rest N6ebf68e22f884a359e135f95d1e1eb93
191 Na1244151e4e948c8baadbaee6c5ebe91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Male
193 rdf:type schema:DefinedTerm
194 Na48cb3b3c8bc4024bf990604054917ae rdf:first sg:person.011023124005.26
195 rdf:rest N13da7bfd9bc747329021850291d07bec
196 Nb1afe71ca66842a0a9f985d7a05c2db4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
197 schema:name Melanesia
198 rdf:type schema:DefinedTerm
199 Nb728f2e163374d779656b127b6d37ecf rdf:first sg:person.01063541463.54
200 rdf:rest N4f898288f46d49c6910d65b1dc8f180a
201 Nba3988c9e62f461e800a81a3d3ea9eaa rdf:first sg:person.0646643507.05
202 rdf:rest rdf:nil
203 Nbab20dcd93f24915a6c26ce81556fa37 rdf:first sg:person.0624243455.41
204 rdf:rest N3eaeda1a3c1d469fb616be659bcb24fe
205 Nc45a4c5851f5449293227e770f8b504a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
206 schema:name Pacific Islands
207 rdf:type schema:DefinedTerm
208 Nc4c0abf2f87747b8996c7b10762999a9 schema:volumeNumber 58
209 rdf:type schema:PublicationVolume
210 Nc72874be6aec42b7989d6a01b7521c5c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Angiotensinogen
212 rdf:type schema:DefinedTerm
213 Ncbaa95e0923044a8abb266e25e48e45a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
214 schema:name Hypertension
215 rdf:type schema:DefinedTerm
216 Nd6e5786c7b5c4fa0a2d5c43dced3044d rdf:first sg:person.0640500420.48
217 rdf:rest Nbab20dcd93f24915a6c26ce81556fa37
218 Nd78247c958e14e3c8995926102802ec0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Genetics, Population
220 rdf:type schema:DefinedTerm
221 Ndee7491ceb714caf82ac7463a5086728 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
222 schema:name Aged
223 rdf:type schema:DefinedTerm
224 Ne2b4656bdd4e4afc86ad135b5952438b rdf:first sg:person.015576331772.42
225 rdf:rest Na08d72eb95d04efebdcb14f0a1e61afd
226 Ne60e97954db64323aae571db62966e44 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
227 schema:name Genetic Association Studies
228 rdf:type schema:DefinedTerm
229 Ne968a4af837a465d9741ed471d18ceb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
230 schema:name Polymorphism, Single Nucleotide
231 rdf:type schema:DefinedTerm
232 Neeebcf5d38514591ae6a9de1f646c501 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
233 schema:name Linkage Disequilibrium
234 rdf:type schema:DefinedTerm
235 Nf4c3dca22d804033ba7877857782619f schema:name dimensions_id
236 schema:value pub.1003619200
237 rdf:type schema:PropertyValue
238 Nfda0bb60c6b84549a3c8e7414cf3eea4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
239 schema:name Genetic Predisposition to Disease
240 rdf:type schema:DefinedTerm
241 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
242 schema:name Biological Sciences
243 rdf:type schema:DefinedTerm
244 anzsrc-for:0604 schema:inDefinedTermSet anzsrc-for:
245 schema:name Genetics
246 rdf:type schema:DefinedTerm
247 sg:grant.5794899 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
248 rdf:type schema:MonetaryGrant
249 sg:grant.6012595 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
250 rdf:type schema:MonetaryGrant
251 sg:grant.6040969 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
252 rdf:type schema:MonetaryGrant
253 sg:grant.6048793 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
254 rdf:type schema:MonetaryGrant
255 sg:grant.6072082 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
256 rdf:type schema:MonetaryGrant
257 sg:grant.6072810 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
258 rdf:type schema:MonetaryGrant
259 sg:grant.6109600 http://pending.schema.org/fundedItem sg:pub.10.1038/jhg.2012.147
260 rdf:type schema:MonetaryGrant
261 sg:journal.1294984 schema:issn 1434-5161
262 1435-232X
263 schema:name Journal of Human Genetics
264 schema:publisher Springer Nature
265 rdf:type schema:Periodical
266 sg:person.01006605255.48 schema:affiliation grid-institutes:grid.31432.37
267 schema:familyName Nakazawa
268 schema:givenName Minato
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01006605255.48
270 rdf:type schema:Person
271 sg:person.01063541463.54 schema:affiliation grid-institutes:grid.258799.8
272 schema:familyName Furusawa
273 schema:givenName Takuro
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063541463.54
275 rdf:type schema:Person
276 sg:person.01065141161.63 schema:affiliation grid-institutes:grid.258777.8
277 schema:familyName Ataka
278 schema:givenName Yuji
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01065141161.63
280 rdf:type schema:Person
281 sg:person.011023124005.26 schema:affiliation grid-institutes:grid.39158.36
282 schema:familyName Yamauchi
283 schema:givenName Taro
284 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011023124005.26
285 rdf:type schema:Person
286 sg:person.01133427520.40 schema:affiliation grid-institutes:grid.472088.1
287 schema:familyName Natsuhara
288 schema:givenName Kazumi
289 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01133427520.40
290 rdf:type schema:Person
291 sg:person.01270026746.37 schema:affiliation grid-institutes:grid.20515.33
292 schema:familyName Naka
293 schema:givenName Izumi
294 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01270026746.37
295 rdf:type schema:Person
296 sg:person.013241054552.08 schema:affiliation grid-institutes:grid.442887.5
297 schema:familyName Matsumura
298 schema:givenName Yasuhiro
299 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013241054552.08
300 rdf:type schema:Person
301 sg:person.015576331772.42 schema:affiliation grid-institutes:grid.26999.3d
302 schema:familyName Ishida
303 schema:givenName Takafumi
304 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015576331772.42
305 rdf:type schema:Person
306 sg:person.0624243455.41 schema:affiliation grid-institutes:grid.267625.2
307 schema:familyName Kimura
308 schema:givenName Ryosuke
309 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624243455.41
310 rdf:type schema:Person
311 sg:person.0640500420.48 schema:affiliation grid-institutes:None
312 schema:familyName Eddie
313 schema:givenName Ricky
314 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0640500420.48
315 rdf:type schema:Person
316 sg:person.0646643507.05 schema:affiliation grid-institutes:grid.20515.33
317 schema:familyName Ohashi
318 schema:givenName Jun
319 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0646643507.05
320 rdf:type schema:Person
321 sg:person.0674751503.28 schema:affiliation grid-institutes:None
322 schema:familyName Ohtsuka
323 schema:givenName Ryutaro
324 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0674751503.28
325 rdf:type schema:Person
326 sg:person.0705040763.44 schema:affiliation grid-institutes:grid.412339.e
327 schema:familyName Inaoka
328 schema:givenName Tsukasa
329 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0705040763.44
330 rdf:type schema:Person
331 sg:pub.10.1007/s00109-003-0482-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011736456
332 https://doi.org/10.1007/s00109-003-0482-3
333 rdf:type schema:CreativeWork
334 sg:pub.10.1007/s00439-009-0768-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031130180
335 https://doi.org/10.1007/s00439-009-0768-9
336 rdf:type schema:CreativeWork
337 sg:pub.10.1007/s10038-006-0375-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036387975
338 https://doi.org/10.1007/s10038-006-0375-8
339 rdf:type schema:CreativeWork
340 sg:pub.10.1007/s10038-007-0198-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015898872
341 https://doi.org/10.1007/s10038-007-0198-2
342 rdf:type schema:CreativeWork
343 sg:pub.10.1007/s11906-007-0004-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004986735
344 https://doi.org/10.1007/s11906-007-0004-8
345 rdf:type schema:CreativeWork
346 sg:pub.10.1023/a:1016280427032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021186916
347 https://doi.org/10.1023/a:1016280427032
348 rdf:type schema:CreativeWork
349 sg:pub.10.1023/a:1018727607651 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015262481
350 https://doi.org/10.1023/a:1018727607651
351 rdf:type schema:CreativeWork
352 sg:pub.10.1038/336307a0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032340039
353 https://doi.org/10.1038/336307a0
354 rdf:type schema:CreativeWork
355 sg:pub.10.1038/35065520 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047123449
356 https://doi.org/10.1038/35065520
357 rdf:type schema:CreativeWork
358 sg:pub.10.1038/ejhg.2010.179 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010315662
359 https://doi.org/10.1038/ejhg.2010.179
360 rdf:type schema:CreativeWork
361 sg:pub.10.1038/ng0198-45 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005273023
362 https://doi.org/10.1038/ng0198-45
363 rdf:type schema:CreativeWork
364 sg:pub.10.1038/sj.clpt.6100090 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027909521
365 https://doi.org/10.1038/sj.clpt.6100090
366 rdf:type schema:CreativeWork
367 grid-institutes:None schema:alternateName Japan Wildlife Research Center, Tokyo, Japan
368 National Gizo Hospital, Ministry of Health and Medical Services, Gizo, The Solomon Islands
369 schema:name Japan Wildlife Research Center, Tokyo, Japan
370 National Gizo Hospital, Ministry of Health and Medical Services, Gizo, The Solomon Islands
371 rdf:type schema:Organization
372 grid-institutes:grid.20515.33 schema:alternateName Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
373 schema:name Doctoral Program in Life System Medical Sciences, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Ibaraki, Japan
374 rdf:type schema:Organization
375 grid-institutes:grid.258777.8 schema:alternateName School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan
376 schema:name School of Policy Studies, Kwansei Gakuin University, Hyogo, Japan
377 rdf:type schema:Organization
378 grid-institutes:grid.258799.8 schema:alternateName Graduate School of Asian and African Area Studies, Kyoto University, Kyoto, Japan
379 schema:name Graduate School of Asian and African Area Studies, Kyoto University, Kyoto, Japan
380 rdf:type schema:Organization
381 grid-institutes:grid.267625.2 schema:alternateName Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan
382 schema:name Transdisciplinary Research Organization for Subtropical and Island Studies (TRO-SIS), University of the Ryukyus, Okinawa, Japan
383 rdf:type schema:Organization
384 grid-institutes:grid.26999.3d schema:alternateName Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
385 schema:name Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan
386 rdf:type schema:Organization
387 grid-institutes:grid.31432.37 schema:alternateName Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan
388 schema:name Department of International Health, Kobe University Graduate School of Health Sciences, Kobe, Japan
389 rdf:type schema:Organization
390 grid-institutes:grid.39158.36 schema:alternateName Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan
391 schema:name Graduate School of Health Sciences, Hokkaido University, Hokkaido, Japan
392 rdf:type schema:Organization
393 grid-institutes:grid.412339.e schema:alternateName Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
394 schema:name Department of Human Ecology, Faculty of Agriculture, Saga University, Saga, Japan
395 rdf:type schema:Organization
396 grid-institutes:grid.442887.5 schema:alternateName Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan
397 schema:name Faculty of Health and Nutrition, Bunkyo University, Kanagawa, Japan
398 rdf:type schema:Organization
399 grid-institutes:grid.472088.1 schema:alternateName The Japanese Red Cross Akita College of Nursing, Akita, Japan
400 schema:name The Japanese Red Cross Akita College of Nursing, Akita, Japan
401 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...