Common variants on 14q32 and 13q12 are associated with DLBCL susceptibility View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-06

AUTHORS

Vinod Kumar, Keitaro Matsuo, Atsushi Takahashi, Naoya Hosono, Tatsuhiko Tsunoda, Naoyuki Kamatani, Sun-Young Kong, Hidewaki Nakagawa, Ri Cui, Chizu Tanikawa, Masao Seto, Yasuo Morishima, Michiaki Kubo, Yusuke Nakamura, Koichi Matsuda

ABSTRACT

Diffuse large B-cell lymphoma (DLBCL) is one of the most aggressive cancers of B-lymphocytes. To investigate genetic susceptibility factors for DLBCL, we performed single-nucleotide polymorphism based genome-wide association study (GWAS) in a total of 399 DLBCL cases and 4243 controls of Japanese population. By following two-stage GWAS approach and an independent replication study, we identified disease susceptibility locus within intron 3 of the CDC42BPB gene on 14q32 (rs751837; P=3.30 × 10(-7) and odds ratio (OR) of 3.5), a region of frequent chromosomal translocations in lymphoma, and variant on 13q12 (rs7097; P=6.57 × 10(-6) and OR of 1.43) which harbors the notch signaling mediator, LNX2 gene. Our findings would contribute to the understanding of DLBCL risk and also may lead to the elucidation of its molecular pathogenesis. More... »

PAGES

436

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2011.35

DOI

http://dx.doi.org/10.1038/jhg.2011.35

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030309553

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21471979


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Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

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curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/jhg.2011.35'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/jhg.2011.35'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/jhg.2011.35'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/jhg.2011.35'


 

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