High prevalence of an anti-hypertriglyceridemic variant of the MLXIPL gene in Central Asia View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2011-12

AUTHORS

Kazuhiro Nakayama, Yoshiko Yanagisawa, Ayumi Ogawa, Yuumi Ishizuka, Lkhagvasuren Munkhtulga, Phitaya Charupoonphol, Somjit Supannnatas, Stevenson Kuartei, Ulziiburen Chimedregzen, Yoshiro Koda, Takafumi Ishida, Yasuo Kagawa, Sadahiko Iwamoto

ABSTRACT

MLXIPL is a transcription factor integral to the regulation of glycolysis and lipogenesis in the liver. Common variants of the MLXIPL gene (MLXIPL) are known to influence plasma triglyceride levels in people of European descent. As MLXIPL has a key role in energy storage, genetic variations of the MLXIPL may be relevant to physiological adaptations to nutritional stresses that have occurred during the evolution of modern humans. In the present study, we assessed the phenotypic consequences of the Q241H variant of MLXIPL in populations of Asian and Oceanian origin and also surveyed the prevalence of Q241H variant in populations worldwide. Multiple linear regression models based on 2373 individuals of Asian origin showed that the H allele was significantly associated with decreased concentrations of plasma triglycerides (P=0.0003). Direct genotyping of 1455 individuals from Africa, Asia and Oceania showed that the triglyceride-lowering H allele was found at quite low frequencies (0.00-0.16) in most of the populations examined. The exceptions were some Central Asian populations, including Mongolians, Tibetans and Uyghurs, which exhibited much higher frequencies of the H allele (0.21-0.26). The high prevalence of the H allele in Central Asia implies that the Q241H variant of MLXIPL might have been significant for utilization of carbohydrates and fats in the common ancestors of these populations, who successfully adapted to the environment of Central Asia by relying on nomadic livestock herding. More... »

PAGES

828

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/jhg.2011.109

DOI

http://dx.doi.org/10.1038/jhg.2011.109

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1044025550

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21938000


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