SNPs on chromosome 5p15.3 associated with myocardial infarction in Japanese population View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11-25

AUTHORS

Asako Aoki, Kouichi Ozaki, Hiroshi Sato, Atsushi Takahashi, Michiaki Kubo, Yasuhiko Sakata, Yoshihiro Onouchi, Takahisa Kawaguchi, Tsung-Hsien Lin, Hitoshi Takano, Masahiro Yasutake, Po-Chao Hsu, Shiro Ikegawa, Naoyuki Kamatani, Tatsuhiko Tsunoda, Suh-Hang H Juo, Masatsugu Hori, Issei Komuro, Kyoichi Mizuno, Yusuke Nakamura, Toshihiro Tanaka

ABSTRACT

Myocardial infarction (MI) occurs as the result of complex interactions of multiple genetic and environmental factors. By conducting a genome wide association study in a Japanese population using 210 785 single nucleotide polymorphism (SNP) markers, we identified a novel susceptible locus for MI on chromosome 5p15.3. An SNP (rs11748327) in this locus showed significant association in several independent cohorts (combined P=5.3 × 10−13, odds ratio=0.80, comparison of allele frequency). Association study using tag SNPs in the same linkage disequilibrium block revealed that two additional SNPs (rs490556 and rs521660) conferred risk of MI. These findings indicate that the SNPs on chromosome 5p15.3 are novel protective genetic factors against MI. More... »

PAGES

47-51

References to SciGraph publications

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  • Journal

    TITLE

    Journal of Human Genetics

    ISSUE

    1

    VOLUME

    56

    Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/jhg.2010.141

    DOI

    http://dx.doi.org/10.1038/jhg.2010.141

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1042803232

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21107343


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