Staphylococcus aureus promoter-lux reporters for drug discovery View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-08

AUTHORS

Lili R Mesak, Shuhua Qi, Ivan Villanueva, Vivian Miao, Julian Davies

ABSTRACT

We describe a collection of antibiotic-activated Staphylococcus aureus promoter-lux reporter strains that can be used to discriminate among antibiotic classes on the basis of their light production response profile. We screened over 400 culture supernatants from previously uncharacterized actinomycetes from soil for the production of aminocoumarin-type compounds and DNA-damaging agents. Novobiocin production was determined in three isolates of Streptomyces, and streptonigrin, a DNA-damaging agent, together with several other bioactive compounds (oxopropaline D and G), was identified from a novel Kitasatospora isolate. This array provides an effective and specific whole-cell approach to search for classes of antimicrobial compounds in unfractionated culture broths. More... »

PAGES

492

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ja.2010.74

DOI

http://dx.doi.org/10.1038/ja.2010.74

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1046337803

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20606700


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JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ja.2010.74'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1038/ja.2010.74'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1038/ja.2010.74'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1038/ja.2010.74'


 

This table displays all metadata directly associated to this object as RDF triples.

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