Biosynthesis of 3′-Deoxy-carbamoylkanamycin C in a Streptomyces tenebrarius Mutant Strain by tacB Gene Disruption View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-02

AUTHORS

Huanzhang Xia, Xianpu Ni, Xifan Hou, Yonghong Yu

ABSTRACT

Streptomyces tenebrarius H6 mainly produces three kinds of antibiotics: apramycin, carbamoyltobramycin and some carbamoylkanamycin B. In our present study, a dehydrogenase gene tacB in the tobramycin biosynthetic gene cluster was disrupted by in-frame deletion. The result of TLC bio-autograph analysis demonstrated the disruption mutant strain produced apramycin and a new antibiotic. The new antibiotic was identified as 3'-deoxy-carbamoylkanamycin C by MS and NMR analysis after isolation and purification. The disruption mutant was restored to produce carbamoyltobramycin in a complementation experiment by the intact tacB gene. Our studies suggested that the tacB gene encodes a 6'-dehydrogenase, which reduces the 6'-hydroxyl group of paromamine to a keto group, thus facilitating the transfer of an aminogroup to form neamine. This study is the first report on the generation of a tobramycin derivative by gene engineering, and will contribute to clarify the complete biosynthetic pathway of tobramycin. More... »

PAGES

63

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ja.2008.111

DOI

http://dx.doi.org/10.1038/ja.2008.111

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1050732208

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18408324


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