High-fat diet alters gut microbiota physiology in mice View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-02

AUTHORS

Hannelore Daniel, Amin Moghaddas Gholami, David Berry, Charles Desmarchelier, Hannes Hahne, Gunnar Loh, Stanislas Mondot, Patricia Lepage, Michael Rothballer, Alesia Walker, Christoph Böhm, Mareike Wenning, Michael Wagner, Michael Blaut, Philippe Schmitt-Kopplin, Bernhard Kuster, Dirk Haller, Thomas Clavel

ABSTRACT

The intestinal microbiota is known to regulate host energy homeostasis and can be influenced by high-calorie diets. However, changes affecting the ecosystem at the functional level are still not well characterized. We measured shifts in cecal bacterial communities in mice fed a carbohydrate or high-fat (HF) diet for 12 weeks at the level of the following: (i) diversity and taxa distribution by high-throughput 16S ribosomal RNA gene sequencing; (ii) bulk and single-cell chemical composition by Fourier-transform infrared- (FT-IR) and Raman micro-spectroscopy and (iii) metaproteome and metabolome via high-resolution mass spectrometry. High-fat diet caused shifts in the diversity of dominant gut bacteria and altered the proportion of Ruminococcaceae (decrease) and Rikenellaceae (increase). FT-IR spectroscopy revealed that the impact of the diet on cecal chemical fingerprints is greater than the impact of microbiota composition. Diet-driven changes in biochemical fingerprints of members of the Bacteroidales and Lachnospiraceae were also observed at the level of single cells, indicating that there were distinct differences in cellular composition of dominant phylotypes under different diets. Metaproteome and metabolome analyses based on the occurrence of 1760 bacterial proteins and 86 annotated metabolites revealed distinct HF diet-specific profiles. Alteration of hormonal and anti-microbial networks, bile acid and bilirubin metabolism and shifts towards amino acid and simple sugars metabolism were observed. We conclude that a HF diet markedly affects the gut bacterial ecosystem at the functional level. More... »

PAGES

295

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  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1038/ismej.2013.155

    DOI

    http://dx.doi.org/10.1038/ismej.2013.155

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003787895

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/24030595


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    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1038/ismej.2013.155'

    N-Triples is a line-based linked data format ideal for batch operations.

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    Turtle is a human-readable linked data format.

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