Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-05-24

AUTHORS

Nina Sanapareddy, Ryan M Legge, Biljana Jovov, Amber McCoy, Lauren Burcal, Felix Araujo-Perez, Thomas A Randall, Joseph Galanko, Andrew Benson, Robert S Sandler, John F Rawls, Zaid Abdo, Anthony A Fodor, Temitope O Keku

ABSTRACT

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn’s disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1–V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas. More... »

PAGES

1858-1868

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ismej.2012.43

DOI

http://dx.doi.org/10.1038/ismej.2012.43

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1033067252

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22622349


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