The human small intestinal microbiota is driven by rapid uptake and conversion of simple carbohydrates View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-19

AUTHORS

Erwin G Zoetendal, Jeroen Raes, Bartholomeus van den Bogert, Manimozhiyan Arumugam, Carien CGM Booijink, Freddy J Troost, Peer Bork, Michiel Wels, Willem M de Vos, Michiel Kleerebezem

ABSTRACT

The human gastrointestinal tract (GI tract) harbors a complex community of microbes. The microbiota composition varies between different locations in the GI tract, but most studies focus on the fecal microbiota, and that inhabiting the colonic mucosa. Consequently, little is known about the microbiota at other parts of the GI tract, which is especially true for the small intestine because of its limited accessibility. Here we deduce an ecological model of the microbiota composition and function in the small intestine, using complementing culture-independent approaches. Phylogenetic microarray analyses demonstrated that microbiota compositions that are typically found in effluent samples from ileostomists (subjects without a colon) can also be encountered in the small intestine of healthy individuals. Phylogenetic mapping of small intestinal metagenome of three different ileostomy effluent samples from a single individual indicated that Streptococcus sp., Escherichia coli, Clostridium sp. and high G+C organisms are most abundant in the small intestine. The compositions of these populations fluctuated in time and correlated to the short-chain fatty acids profiles that were determined in parallel. Comparative functional analysis with fecal metagenomes identified functions that are overrepresented in the small intestine, including simple carbohydrate transport phosphotransferase systems (PTS), central metabolism and biotin production. Moreover, metatranscriptome analysis supported high level in-situ expression of PTS and carbohydrate metabolic genes, especially those belonging to Streptococcus sp. Overall, our findings suggest that rapid uptake and fermentation of available carbohydrates contribute to maintaining the microbiota in the human small intestine. More... »

PAGES

1415-1426

Identifiers

URI

http://scigraph.springernature.com/pub.10.1038/ismej.2011.212

DOI

http://dx.doi.org/10.1038/ismej.2011.212

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1043234942

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22258098


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69 gastrointestinal tract
70 genes
71 healthy individuals
72 high levels
73 human gastrointestinal tract
74 human small intestinal microbiota
75 human small intestine
76 ileostomists
77 individuals
78 intestinal metagenome
79 intestinal microbiota
80 intestine
81 levels
82 limited accessibility
83 location
84 mapping
85 metabolic genes
86 metabolism
87 metagenomes
88 metatranscriptome analysis
89 microarray analysis
90 microbes
91 microbiota
92 microbiota composition
93 model
94 most studies
95 mucosa
96 organisms
97 parallel
98 part
99 phosphotransferase system
100 phylogenetic microarray analysis
101 population
102 production
103 profile
104 rapid uptake
105 samples
106 short-chain fatty acid profile
107 simple carbohydrates
108 single individual
109 situ expression
110 small intestinal microbiota
111 small intestine
112 sp
113 study
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115 time
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